• 1. The Second People's Hospital of Henan Province, Zhengzhou 451191, China;
  • 2. Henan Provincial People's Hospital, Zhengzhou 450000, China;
GAO Li, Email: 1879872583@qq.com
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Objective To analyze the clinical efficacy and safety of rapamycin in the treatment of Tuberous sclerosis complex ( TSC ) complicated with refractory epilepsy, and to provide scientific basis for the clinical treatment of this disease.Methods Retrospective analysis was performed on 22 children with TSC complicated with refractory epilepsy admitted to Henan People's Hospital from 2017 to 2019, including 11 males and 11 females who met the inclusion criteria, with an average age of (27.91±36.92) months. They were treated with antiepileptic drugs and rapamycin at the same time, and followed up for at least 1 year.To observe the change of seizure frequency before and after treatment with rapamycin.Results The mean reduction rate of seizure frequency in children with tuberous sclerosis complicated with refractory epilepsy was 52.1% 6 months after the addition of rapamycin, and 51.2% 12 months after the addition of rapamycin. The number of seizure-free days could be maintained. The difference before and after the addition of rapamycin was statistically significant (P<0.05).Conclusion The addition of rapamycin in the treatment of TSC complicated with refractory epilepsy can reduce the frequency of seizure and increase the number of days without seizure, and the adverse reactions are mild/moderate. Rapamycin has certain safety in children with regular follow-up.

Citation: FENG Jie, GAO Li, CHENG Shuhua, WANG Xuezeng, LI Yan, MA Min. Clinical observation of rapamycin in the treatment of tuberous sclerosis complicated with refractory epilepsy. Journal of Epilepsy, 2021, 7(5): 402-405. doi: 10.7507/2096-0247.20210065 Copy

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