Intraocular Pressure Sensor Based on a Contact Lens_Journal of Biomedical Engineering

Authors：

GUOXuhong ¹ ,  PEIWeihua ¹ , YAOZhaolin ¹ , CHENYuanfang ¹ , HUXiaohui ¹ , CHENHongda ¹ , ZHUJingyuan ² , WUHuijuan ²

1. Institute of Semiconductors CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing 100083, China;
2. Peking University People’s Hospital, Beijing 100044, China;

Corresponding author：

PEIWeihua, Email: peiwh@semi.ac.cn

Keywords：

contact lens; intraocular pressure; micro-electron mechanical systems; strain gauge

DOI：

10.7507/1001-5515.20160005

Video：

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Intraocular pressure detection has a great significance for understanding the status of eye health, prevention and treatment of diseases such as glaucoma. Traditional intraocular pressure detection needs to be held in the hospital. It is not only time-consuming to doctors and patients, but also difficult to achieve 24 hour-continuous detection. Microminiaturization of the intraocular pressure sensor and wearing it as a contact lens, which is convenient, comfortable and noninvasive, can solve this problem because the soft contact lens with an embedded micro fabricated strain gauge allows the measurement of changes in corneal curvature to correlate to variations of intraocular pressure. We fabricated a strain gauge using micro-electron mechanical systems, and integrated with the contact lens made of polydimethylsiloxane (PDMS) using injection molding. The experimental results showed that the sensitivity was 100.7 μV/μm. When attached to the corneal surface, the average sensitivity of sensor response of intraocular pressure can be 125.8 μV/mm Hg under the ideal condition.

Citation： GUOXuhong, PEIWeihua, YAOZhaolin, CHENYuanfang, HUXiaohui, CHENHongda, ZHUJingyuan, WUHuijuan. Intraocular Pressure Sensor Based on a Contact Lens. Journal of Biomedical Engineering, 2016, 33(1): 18-22. doi: 10.7507/1001-5515.20160005 Copy

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11.	刘祖国, 谢玉环, 张梅. 正常人角膜前后表面地形及全角膜厚度的研究[J]. 中华眼科杂志, 2001, 37(2): 125-128.
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1. 张学勇, 马建国, 卢荣胜. 眼压检测技术应用研究[J]. 合肥工业大学学报:自然科学版, 2011, 47(7): 976-981.
2. 虞启琏, 王琳, 赵安宁, 等. 医用光学仪器[M]. 天津: 天津科学技术出版社, 1988: 76-78.
3. CHEN G Z, CHAN I S, LEUNG L K, et al. Soft wearable contact lens sensor for continuous intraocular pressure monitoring[J]. Med Eng Phys, 2014, 36(9): 1134-1139.
4. HUANG Y C, YEH G T, YANG T S, et al. A contact lens sensor system with a micro-capacitor for wireless intraocular pressure monitoring[C]//Proceedings of 2013 IEEE Sensors. Baltimore,MD:2013: 1-4.
5. LAUKHIN V, SNCHEZ I, MOYA A, et al. Non-invasive intraocular pressure monitoring with a contact lens engineered with a nanostructured polymeric sensing film[J]. Sens Actuators A Phys, 2011, 170(1): 36-43.
6. LEONARDI M, PITCHON E M, BERTSCH A, et al. Wireless contact lens sensor for intraocular pressure monitoring: assessment on enucleated pig eyes[J]. Acta Ophthalmol, 2009, 87(4): 433-437.
7. HJORTDAL J O, JENSEN P K. In vitro measurement of corneal strain, thickness, and curvature using digital image processing[J]. Acta Ophthalmol Scand, 1995, 73(1): 5-11.
8. LAM A C, DOUTHWAITE W A. The effect of an artificially elevated intraocular pressure on the central corneal curvature[J]. Ophthalmic Physiol Opt, 1997, 17: 18-24.
9. 李尧, 孙鹏, 王永超. 提高惠斯通电桥灵敏度的方法[J]. 大学物理实验, 2011, 24(2): 28-31,42.
10. 练苹, 顾欣祖, 叶秀兰. 正常人瞳孔及瞳孔对光反射的特征[J]. 中国实用眼科杂志, 2005, 23(10): 1038-1041.
11. 刘祖国, 谢玉环, 张梅. 正常人角膜前后表面地形及全角膜厚度的研究[J]. 中华眼科杂志, 2001, 37(2): 125-128.
12. 北京科技大学, 东北大学.工程力学-材料力学[M]. 北京: 高等教育出版社, 1997: 124-130.

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Journal of Biomedical Engineering

Intraocular Pressure Sensor Based on a Contact Lens

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