Development of a balloon sensor device for force-electrical coupling measurement of esophagus_Journal of Biomedical Engineering

Authors：

RAN Peng ,  ZHONG Ying , LAI Yingbing , LIU Lei , ZHU Yanhang , ZHU Huantao

School of Life Health Information Science and Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, P. R. China;

Corresponding author：

ZHONG Ying, Email: 1410160372@qq.com

Keywords：

Flexible balloon sensor; Polyvinylidene fluoride; Force-electric coupling measurement; Electrical impedance measurement

DOI：

10.7507/1001-5515.202404019

Video：

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Abstract Full text Figures/Tables Video References Cited by

To address the challenges of capturing micro-strains in detecting esophageal motility disorders and the limitations of existing high-resolution manometry and functional intraluminal imaging probes in directly measuring esophageal tissue electrical impedance, this study proposes a novel flexible balloon sensor structure that integrates a piezoelectric film assembly with a distributed impedance electrode array. Using the electrical analysis module in the finite element analysis (FEA) software, simulations of the forward problem for esophageal impedance detection were conducted to optimize the excitation source parameters, and a physical prototype was fabricated. Under a relative excitation mode with a voltage sensitivity of 2.059%, the voltage output characteristics of the impedance electrode array were analyzed during linear changes in the balloon filling volume. Based on the performance variation of the piezoelectric film assembly, 80% was selected as the optimal filling volume. Force-electric coupling tests were conducted on the balloon sensor using a pressure testing platform, revealing that both the piezoelectric film assembly inside the balloon and the impedance electrodes outside the balloon exhibited significant load differentiation characteristics as the force application point shifted. In summary, this balloon sensor facilitates the localization of force application while simultaneously analyzing esophageal tissue properties, offering a novel diagnostic approach and objective tool for esophageal disease detection.

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3.	Spreafico G, Chiurazzi M, Bagnoli D, et al. Endoluminal procedures and devices for esophageal tract investigation: a critical review. Sensors, 2023, 23(21): 8858.
4.	李来斌, 王松, 郑佳, 等. 上消化道造影与食道三维CT扫描在食道癌诊断中的临床价值. 医学影像学杂志, 2023, 33(4): 693-696.
5.	李少芳, 韦敏. 用电阻抗法自动血细胞分析仪检测血小板的影响因素研究. 当代医药论丛, 2017, 15(12): 110-111.
6.	Li Minchuan, Ran Peng, Zhong Ying, et al. Dynamic coupled physical field modeling of a flexible balloon-catheter system using a piezoelectric sensing array under simulated esophageal peristalsis. IEEE Sensors Journal, 2024, 24(21): 34676-34690.
7.	Wang Song, Yan Jin, Zhu Canlin, et al. A low contact impedance medical flexible electrode based on a pyramid array micro-structure. Micromachines, 2020, 11(1): 57.
8.	Huang Wentao, Xia Jie, Wang Xuepei, et al. Improvement of non-destructive detection of lamb freshness based on dual-parameter flexible temperature-impedance sensor. Food Control, 2023, 153: 109963.
9.	Savarino E, Marabotto E, Bodini G, et al. Advancements in the use of manometry and impedance testing for esophageal functional disorders. Expert Review of Gastroenterology & Hepatology, 2019, 13(5): 425-435.
10.	Carlson D A, Kahrilas P J, Lin Z, et al. Evaluation of esophageal motility utilizing the functional lumen imaging probe. Am J Gastroenterol, 2016, 111(12): 1726-1735.
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12.	Gyawali C P, Kahrilas P J. A short history of high-resolution esophageal manometry. Dysphagia, 2023, 38(2): 586-595.
13.	Chitose S I, Shin Y, Sato K, et al. Three-dimensional imaging of upper esophageal sphincter resting pressure. Laryngoscope Investigative Otolaryngology, 2019, 4(6): 645-652.
14.	Triantafyllou T, Doulami G, Papailiou J, et al. Real-time continuous esophageal high-resolution manometry (HRM) during laparoscopic Heller myotomy and Dor fundoplication for the treatment of achalasia. A promising novelty in regards of perfecting surgical technique: could it guide surgical technique toward excellent results?. Surgical Laparoscopy Endoscopy & Percutaneous Techniques, 2016, 26(6): e163-e166.
15.	Rengarajan A, Rogers B D, Wong Z, et al. High-resolution manometry thresholds and motor patterns among asymptomatic individuals. Clinical Gastroenterology and Hepatology, 2022, 20(3): e398-e406.
16.	Omari T, Cock C, Wu P, et al. Using high resolution manometry impedance to diagnose upper esophageal sphincter and pharyngeal motor disorders. Neurogastroenterology & Motility, 2023, 35(1): e14461.
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18.	Pandolfino J, Carlson D. Post-operative HRIM and FLIP for dysphagia following antireflux procedures. Hiatal Hernia Surgery, 2018: 179-196.
19.	Ran Peng, Li Minchuan, Zhang Kunlin, et al. Development and evaluation of a flexible PVDF-based balloon sensor for detecting mechanical forces at key esophageal nodes in esophageal motility disorders. Biosensors, 2023, 13(8): 791.
20.	丁文龙, 刘学政. 系统解剖学. 第9版. 北京: 人民卫生出版社. 2018: 131-132.
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22.	Dong Xingkun, Qin Lei, Cheng Xin, et al. Factors affecting electrical impedance tomography: a review. Lecture Notes in Electrical Engineering, 2021: 978-981.
23.	李星, 杨帆, 余晓, 等. 基于自诊断正则化的电阻抗成像逆问题研究. 生物医学工程学杂志, 2018, 35(3): 460-467.
24.	李昊庭, 徐灿华, 刘本源, 等. 稀疏加权算法与 GREIT算法在颅脑电阻抗成像中的对比研究. 中国医疗设备, 2016, 31(11): 23-27.
25.	Moriwaki T, Okamoto Y, Yamaga H, et al. In vitro measurement of contact pressure applied to a model vessel wall during balloon dilation by using a film-type sensor. Journal of Neuroendovascular Therapy, 2022, 16(4): 192-197.
26.	刘圣蓉, 苏丹, 庞宇, 等. 基于不同频率的动态人体模型的SAR研究. 北京理工大学学报, 2015, 35(1): 105-110.
27.	Schiavone A, Zhao L G. A computational study of stent performance by considering vessel anisotropy and residual stresses. Mater Sci Eng C Mater Biol Appl, 2016, 62: 307-316.
28.	徐浩, 王欣阳, 魏云冰, 等. 基于最小二乘法的活体触电动态阻抗分析. 电气工程学报, 2023, 18(3): 268-276.

1. 刘香, 许坤明, 朱凯, 等. 食管癌肿瘤免疫微环境的研究进展. 齐齐哈尔医学院学报, 2023, 44(8): 757-761.
2. Meves V, Behrens A, Pohl J. Diagnostics and early diagnosis of esophageal cancer. Viszeralmedizin, 2015, 31(5): 315-318.
3. Spreafico G, Chiurazzi M, Bagnoli D, et al. Endoluminal procedures and devices for esophageal tract investigation: a critical review. Sensors, 2023, 23(21): 8858.
4. 李来斌, 王松, 郑佳, 等. 上消化道造影与食道三维CT扫描在食道癌诊断中的临床价值. 医学影像学杂志, 2023, 33(4): 693-696.
5. 李少芳, 韦敏. 用电阻抗法自动血细胞分析仪检测血小板的影响因素研究. 当代医药论丛, 2017, 15(12): 110-111.
6. Li Minchuan, Ran Peng, Zhong Ying, et al. Dynamic coupled physical field modeling of a flexible balloon-catheter system using a piezoelectric sensing array under simulated esophageal peristalsis. IEEE Sensors Journal, 2024, 24(21): 34676-34690.
7. Wang Song, Yan Jin, Zhu Canlin, et al. A low contact impedance medical flexible electrode based on a pyramid array micro-structure. Micromachines, 2020, 11(1): 57.
8. Huang Wentao, Xia Jie, Wang Xuepei, et al. Improvement of non-destructive detection of lamb freshness based on dual-parameter flexible temperature-impedance sensor. Food Control, 2023, 153: 109963.
9. Savarino E, Marabotto E, Bodini G, et al. Advancements in the use of manometry and impedance testing for esophageal functional disorders. Expert Review of Gastroenterology & Hepatology, 2019, 13(5): 425-435.
10. Carlson D A, Kahrilas P J, Lin Z, et al. Evaluation of esophageal motility utilizing the functional lumen imaging probe. Am J Gastroenterol, 2016, 111(12): 1726-1735.
11. Patel A, Schnoll-Sussman F, Gyawali C P. Diagnostic testing for esophageal motility disorders: barium radiography, high-resolution manometry, and the functional lumen imaging probe (FLIP). The AFS Textbook of Foregut Disease, Cham: Springer International Publishing, 2023: 269-278.
12. Gyawali C P, Kahrilas P J. A short history of high-resolution esophageal manometry. Dysphagia, 2023, 38(2): 586-595.
13. Chitose S I, Shin Y, Sato K, et al. Three-dimensional imaging of upper esophageal sphincter resting pressure. Laryngoscope Investigative Otolaryngology, 2019, 4(6): 645-652.
14. Triantafyllou T, Doulami G, Papailiou J, et al. Real-time continuous esophageal high-resolution manometry (HRM) during laparoscopic Heller myotomy and Dor fundoplication for the treatment of achalasia. A promising novelty in regards of perfecting surgical technique: could it guide surgical technique toward excellent results?. Surgical Laparoscopy Endoscopy & Percutaneous Techniques, 2016, 26(6): e163-e166.
15. Rengarajan A, Rogers B D, Wong Z, et al. High-resolution manometry thresholds and motor patterns among asymptomatic individuals. Clinical Gastroenterology and Hepatology, 2022, 20(3): e398-e406.
16. Omari T, Cock C, Wu P, et al. Using high resolution manometry impedance to diagnose upper esophageal sphincter and pharyngeal motor disorders. Neurogastroenterology & Motility, 2023, 35(1): e14461.
17. Carlson D A, Gyawali C P, Khan A, et al. Classifying esophageal motility by FLIP panometry: a study of 722 subjects with manometry. Am J Gastroenterol, 2021, 116(12): 2357-2366.
18. Pandolfino J, Carlson D. Post-operative HRIM and FLIP for dysphagia following antireflux procedures. Hiatal Hernia Surgery, 2018: 179-196.
19. Ran Peng, Li Minchuan, Zhang Kunlin, et al. Development and evaluation of a flexible PVDF-based balloon sensor for detecting mechanical forces at key esophageal nodes in esophageal motility disorders. Biosensors, 2023, 13(8): 791.
20. 丁文龙, 刘学政. 系统解剖学. 第9版. 北京: 人民卫生出版社. 2018: 131-132.
21. Giuseppe B F, Maurizio R, Emilio P, et al. Esophageal anatomy and physiology//Morph-odynamic imaging in achalasia. CRC Press, 2023: 21-33.
22. Dong Xingkun, Qin Lei, Cheng Xin, et al. Factors affecting electrical impedance tomography: a review. Lecture Notes in Electrical Engineering, 2021: 978-981.
23. 李星, 杨帆, 余晓, 等. 基于自诊断正则化的电阻抗成像逆问题研究. 生物医学工程学杂志, 2018, 35(3): 460-467.
24. 李昊庭, 徐灿华, 刘本源, 等. 稀疏加权算法与 GREIT算法在颅脑电阻抗成像中的对比研究. 中国医疗设备, 2016, 31(11): 23-27.
25. Moriwaki T, Okamoto Y, Yamaga H, et al. In vitro measurement of contact pressure applied to a model vessel wall during balloon dilation by using a film-type sensor. Journal of Neuroendovascular Therapy, 2022, 16(4): 192-197.
26. 刘圣蓉, 苏丹, 庞宇, 等. 基于不同频率的动态人体模型的SAR研究. 北京理工大学学报, 2015, 35(1): 105-110.
27. Schiavone A, Zhao L G. A computational study of stent performance by considering vessel anisotropy and residual stresses. Mater Sci Eng C Mater Biol Appl, 2016, 62: 307-316.
28. 徐浩, 王欣阳, 魏云冰, 等. 基于最小二乘法的活体触电动态阻抗分析. 电气工程学报, 2023, 18(3): 268-276.

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