Cycloxygenase-2 Expression in Patients with Gastric Ulcer and Gastric Cancer and Its Relationship with Helicobacter Pylori_West China Medical Journal

Authors：

XIA Xiaoyan ¹ , WEN Liming ² , ZHOU Ning ² , YANG Ming ¹ , SHI Yong. ¹

1. People’s Hospital of Mianyang, Mianyang, Sichuan 621000, P. R. China; 2. The Second Affiliated Hospital of North Sichuan Medical College, Mianyang, Sichuan 621000, P. R. China;

Corresponding author：

Keywords：

胃溃疡; 胃癌; 环氧化酶-2; 幽门螺杆菌; 免疫组织化学

DOI：

10.7507/1002-0179.20130058

Video：

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目的　探讨环氧化酶-2（COX-2）在幽门螺杆菌（Hp）感染与非感染性胃溃疡及胃癌的表达。方法　选择绵阳市404医院消化内科2011年2月－2012年2月的门诊及住院患者，用免疫组织化学方法检测196例经胃镜和组织病理学检查明确为胃溃疡（病理分型：肠上皮化生、异型增生）、胃癌及正常胃黏膜者的胃黏膜COX-2蛋白的表达，比较各病理分类之间及Hp感染与非感染之间COX-2蛋白表达的差异。结果　胃溃疡（肠上皮化生、异型增生）、胃癌组的炎症细胞、腺上皮细胞、癌细胞及极少量正常黏膜上皮细胞中有COX-2表达。从正常胃黏膜-胃溃疡（肠上皮化生、异型增生）-胃癌COX-2的阳性表达有逐渐增强的趋势（P＜0.05）。Hp阳性组COX-2的阳性表达高于Hp阴性组（P＜0.05），胃癌组COX-2的阳性表达高于胃溃疡组（P＜0．05）。结论　COX-2在胃癌的表达高于胃溃疡。Hp感染可诱导COX-2过度表达。

Citation： XIA Xiaoyan,WEN Liming,ZHOU Ning,YANG Ming,SHI Yong.. Cycloxygenase-2 Expression in Patients with Gastric Ulcer and Gastric Cancer and Its Relationship with Helicobacter Pylori. West China Medical Journal, 2013, 28(2): 179-183. doi: 10.7507/1002-0179.20130058 Copy

1.	Dannenberg AJ, Altorki NK, Boyle JO, et al. Cyclo-oxygenase 2: a pharmacological target for the prevention of cance[J]. Lancet Oncol, 2001, 2(9): 544-551.
2.	Howe LR, Dannenberg AJ. A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer[J]. Semin Oncol, 2002, 29 (3 Suppl 11): 111-119.
3.	Yang XG, Zhang HZ, Wei L, et al. The expression of cyclooxygenase-2 (Cox-2) and p16 in non-Hodgkin’s lymphomas and its climcal significance[J]. Chinese-German Clin Oncol, 2009, 8(2): 104-109．.
4.	Ferrandina G, Lauriola L, Distefano MG, et al. Increased cycloxygenase-2 expression is associated with chemotherapy resistance and poor surviral in cervical cancer patients[J]. J Clin Oncol, 2002, 20(4)：973-981．.
5.	Lim HY, Joo HJ, Choi JH, et al. Increased expression of cyclooxygenase-2 protein in human gastric carcinoma[J]. Clin Cancer Res, 2000, 6(2)：519-525．.
6.	van Rees BP, Saukkonen K, Ristimaki A, et al. Cyclooxygenase-2 overexpression during carcinogenesis in the human stomach[J]. J Pathol, 2002, 196(2)：171-179.
7.	Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2[J]. Cell, 1995, 83(3): 493-501.
8.	Jones MK, Wang H, Peskar BM, et al. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs:insight into mechanisms and implications for cancer growth and ulcer healing[J]. Nat Med, 1999, 5(12): 1418-1423.
9.	McGinty A, Chang YW, Sorokin A, et al. Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor -differentiated PC12 cells[J]. J Biol Chem, 2000, 275(16): 12095-12101.
10.	Kishimoto Y, Yashima K, Morisawa T, et al. Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane[J]. J Gastroenterol, 2002, 37(3): 186-193.
11.	程慧敏, 毛福珍, 王少青, 等．幽门螺杆菌相关性胃炎中的不典型增生[J]. 中华消化内镜杂志, 1994, 11(2): 85-86.
12.	胡小安, 张润, 卢静. 特殊染色与免疫组化染色显示幽门螺杆菌的效果对比[J]. 临床与实验病理学杂志, 2009, 25(2): 222-223.
13.	罗玉琴, 吴开春．浅表性胃炎、胃黏膜不典型增生及胃癌组织中COX-1、COX-2、iNOS表达的意义[J]. 中华消化杂志, 2000, 20(4)：223-226．.

1. 　Dannenberg AJ, Altorki NK, Boyle JO, et al. Cyclo-oxygenase 2: a pharmacological target for the prevention of cance[J]. Lancet Oncol, 2001, 2(9): 544-551.
2. 　Howe LR, Dannenberg AJ. A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer[J]. Semin Oncol, 2002, 29 (3 Suppl 11): 111-119.
3. 　Yang XG, Zhang HZ, Wei L, et al. The expression of cyclooxygenase-2 (Cox-2) and p16 in non-Hodgkin’s lymphomas and its climcal significance[J]. Chinese-German Clin Oncol, 2009, 8(2): 104-109．.
4. 　Ferrandina G, Lauriola L, Distefano MG, et al. Increased cycloxygenase-2 expression is associated with chemotherapy resistance and poor surviral in cervical cancer patients[J]. J Clin Oncol, 2002, 20(4)：973-981．.
5. 　Lim HY, Joo HJ, Choi JH, et al. Increased expression of cyclooxygenase-2 protein in human gastric carcinoma[J]. Clin Cancer Res, 2000, 6(2)：519-525．.
6. 　van Rees BP, Saukkonen K, Ristimaki A, et al. Cyclooxygenase-2 overexpression during carcinogenesis in the human stomach[J]. J Pathol, 2002, 196(2)：171-179.
7. 　Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2[J]. Cell, 1995, 83(3): 493-501.
8. 　Jones MK, Wang H, Peskar BM, et al. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs:insight into mechanisms and implications for cancer growth and ulcer healing[J]. Nat Med, 1999, 5(12): 1418-1423.
9. 　McGinty A, Chang YW, Sorokin A, et al. Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor -differentiated PC12 cells[J]. J Biol Chem, 2000, 275(16): 12095-12101.
10. 　Kishimoto Y, Yashima K, Morisawa T, et al. Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane[J]. J Gastroenterol, 2002, 37(3): 186-193.
11. 　程慧敏, 毛福珍, 王少青, 等．幽门螺杆菌相关性胃炎中的不典型增生[J]. 中华消化内镜杂志, 1994, 11(2): 85-86.
12. 　胡小安, 张润, 卢静. 特殊染色与免疫组化染色显示幽门螺杆菌的效果对比[J]. 临床与实验病理学杂志, 2009, 25(2): 222-223.
13. 　罗玉琴, 吴开春．浅表性胃炎、胃黏膜不典型增生及胃癌组织中COX-1、COX-2、iNOS表达的意义[J]. 中华消化杂志, 2000, 20(4)：223-226．.

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West China Medical Journal

Cycloxygenase-2 Expression in Patients with Gastric Ulcer and Gastric Cancer and Its Relationship with Helicobacter Pylori

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