ZHAOJing-sheng 1 , HULong-fei 2 , ZHANGXiang-yang 3 , ZHAOBao-ping 3 , DANGRong-fang 4 , XUEXiao-ling 4
  • 1. HIFU Center, Maternal and Child Health Care Hospital, Baoji, Shaanxi 721000, P. R. China;
  • 2. Imaging Department, Maternal and Child Health Care Hospital, Baoji, Shaanxi 721000, P. R. China;
  • 3. Imaging Department, PLA 537 Hospital, Baoji, Shaanxi 721000, P. R. China;
  • 4. Department of Gynecology, Maternal and Child Health Care Hospital, Baoji, Shaanxi 721000, P. R. China;
HULong-fei, Email: zhaojsyj@126.com
Uterine fibroids; High-intensity focused ultrasound; Curative effect
10.7507/1002-0179.20150646
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Objective To probe into the clinical efficacy of high-intensity focused ultrasound (HIFU) alone for uterine fibroids. Method Between February 2012 and February 2014, 145 patients with 174 cases of uterine fibroids were treated with HIFU. Before and one day, 6 months, 12 months after treatment, MRI was performed during the follow-up. We analyzed fibroids narrowing rate, adverse reactions, and clinical symptoms improvement after treatment. Results Successful completion of HIFU ablation was done for all the fibroids. Enhanced MRI examination before and one day after treatment, and MRI plain scanning 6 and 12 months after treatment showed that fibroid volume before treatment was 4.61-419.70 cm3 (median of 56.82 cm3), fibroid volume after treatment was 3.02-578.21 cm3 (median of 56.74 cm3), ablation volume was 2.42-578.21 cm3 (median of 47.84 cm3), and volumetric ablation rate was 24%-100%; there was no statistically significant difference in fibroid volume before and after treatment (P>0.05); fibroid volume 6 months after treatment was 0-264.50 cm3 (median of 22.49 cm3) and was 0-346.02 cm3 (median of 14.81 cm3) 12 months after treatment with a reduction rate of 60.4% and 73.9% on average respectively, and the volume was significantly different between those two time points and before treatment (P<0.05), and between 6 months and 12 months after treatment (P<0.05). The medians of uterine fibroid symptoms (UFS) and quality of life (QOL) scores before ablation were respectively 21.88 and 71.55 points. UFS reduced by 57.1% and 71.4% respectively 6 and 12 months after ablation, and QOL increased by 15.7% and 26.5% at those two time points. Both UFS and QOL 6 and 12 months after treatment were significantly different from that before treatment (P<0.05), and the UFS and QOL difference between 6 months and 12 months after treatment was also significant (P<0.05). As time went on, UFS gradually reduced, while QOL gradually increased. Complication rate was 2.8% with two cases of skin shallow degree-Ⅱ thermal damage, one of lower limb radiation pain, one of urinary retention, and there were 6 cases of recurrence during the follow-up. Conclusions HIFU treatment for uterine fibroids is safe and effective, and is an alternative choice for conventional treatment when it is unable to retain the womb or when the patient refuses surgical treatment.

Citation： ZHAOJing-sheng, HULong-fei, ZHANGXiang-yang, ZHAOBao-ping, DANGRong-fang, XUEXiao-ling. Curative Effect Observation on High-intensity Focused Ultrasound Treatment for Uterine Fibroids. West China Medical Journal, 2015, 30(12): 2254-2257. doi: 10.7507/1002-0179.20150646 Copy

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