Diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 and cyclooxygenase-2 in abdominal infection-caused sepsis_West China Medical Journal

Authors：

ZENG Hui ¹ , WANG Guiyan ² ,  LIU Jian ² , LIU Binwei ²

1. Department of Medical Examination Center, the First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P. R. China;
2. Department of General Surgery, the First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P. R. China;

Corresponding author：

LIU Jian, Email: haijian56480476@163.com

Keywords：

Abdominal infection; sepsis; soluble triggering receptor expressed on myeloid cell-1; cyclooxygenase-2; condition; prognosis

DOI：

10.7507/1002-0179.202304045

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To study the diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) and cyclooxygenase-2 (COX-2) in abdominal infection-caused sepsis. Methods A total of 170 patients with abdominal infection treated in the First Hospital of Qinhuangdao between January 2019 and March 2022 were retrospectively selected and divided into sepsis group (n=76) and non-sepsis group (n=94) according to whether they were combined with abdominal infection-caused sepsis. In addition, 80 healthy people in the same period were selected as the control group. The levels of serum sTREM-1 and COX-2 in the three groups were detected and the differences were compared. The laboratory indexes, including white blood cell count, high-sensitivity C-reactive protein, and procalcitonin of patients with abdominal infection-caused sepsis were detected. The Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation System Ⅱ and prognosis (survival or death) of patients with abdominal infection-caused sepsis were evaluated. The correlations of serum sTREM-1 and COX-2 with the severity of sepsis were analyzed, and the diagnostic and prognostic value of sTREM-1 and COX-2 in abdominal infection-caused sepsis was assessed. Results The levels of serum sTREM-1 and COX-2 in the sepsis group were higher than those in the control group and the non-sepsis group (P<0.05). The levels of serum sTREM-1 and COX-2 in the sepsis group were positively correlated with white blood cell count, high-sensitivity C-reactive protein, procalcitonin, Sequential Organ Failure Assessment score, Acute Physiology and Chronic Health Evaluation System Ⅱ score (P<0.05). The serum levels of sTREM-1 and COX-2 of patients who died during hospitalization in the sepsis group were higher than those of the surviving patients. The areas under the receiver operating characteristic curves of the serum sTREM-1 and COX-2 levels for diagnosing sepsis caused by abdominal infection were 0.814 [95% confidence interval (CI) (0.746, 0.882), P<0.001] and 0.848 [95%CI (0.788, 0.905), P<0.001], respectively, with critical values of 1.879 pg/mL and 18.75 ng/mL, respectively, and those for predicting the prognosis of patients with sepsis caused by abdominal infection were 0.775 [95%CI (0.659, 0.890), P<0.001] and 0.784 [95%CI (0.679, 0.889), P<0.001], respectively, with critical values of 2.283 pg/mL and 23.02 ng/mL, respectively (P<0.05). Conclusion The serum levels of sTREM-1 and COX-2 have certain value in the diagnosis and prognosis prediction of abdominal infection-caused sepsis.

Citation： ZENG Hui, WANG Guiyan, LIU Jian, LIU Binwei. Diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 and cyclooxygenase-2 in abdominal infection-caused sepsis. West China Medical Journal, 2023, 38(11): 1709-1713. doi: 10.7507/1002-0179.202304045 Copy

1.	Blot S, Antonelli M, Arvaniti K, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Med, 2019, 45(12): 1703-1717.
2.	Chou EH, Mann S, Hsu TC, et al. Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: a nationwide study. PLoS One, 2020, 15(1): e0227752.
3.	况刚, 陈勇, 魏旭升, 等. 24 h LCR、SOFA 评分及 SAPSⅡ评分在腹腔感染致脓毒症患者预后评估中的作用. 湖南师范大学学报(医学版), 2020, 17(1): 26-29.
4.	Qu Z, Zhu Y, Wang M, et al. Prognosis and risk factors of sepsis patients in Chinese ICUs: a retrospective analysis of a cohort database. Shock, 2021, 56(6): 921-926.
5.	Dadkhah A, Fatemi F, Rasooli A, et al. Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. Pharm Biol, 2018, 56(1): 495-504.
6.	刘胜蕊, 史晓峰, 王兵, 等. 腹腔感染性脓毒症可溶性髓样细胞触发受体(sTREM-1)与 Janus 激酶-信号转导和转录激活因子(JAK/STAT)通路的关系. 中华急诊医学杂志, 2016, 25(3): 314-319.
7.	李瑞萍, 宋伟. 血浆 sTREM-1、sFLT-1 及 APACHEⅡ评分对重症肺炎患者预后评估价值. 国际呼吸杂志, 2018, 38(13): 968-971.
8.	Verma AK, Pandey AK, Singh A, et al. Increased serum levels of matrix-metalloproteinase-9, cyclo-oxygenase-2 and prostaglandin E-2 in patients with chronic obstructive pulmonary disease (COPD). Indian J Clin Biochem, 2022, 37(2): 169-177.
9.	中华医学会外科学分会外科感染与重症医学学组, 中国医师协会外科医师分会肠瘘外科医师专业委员会. 中国腹腔感染诊治指南(2019 版). 中国实用外科杂志, 2020, 40(1): 1-16.
10.	中国医师协会急诊医师分会, 中国研究型医院学会休克与脓毒症专业委员会. 中国脓毒症/脓毒性休克急诊治疗指南(2018). 中国急救医学, 2018, 38(9): 741-756.
11.	魏锋, 洪志敏, 董海涛, 等. ICU 重度脓毒症的流行病学特点及预后影响因素的分析. 中华医院感染学杂志, 2018, 28(10): 1469-1471, 1484.
12.	陶丽丽, 张振辉, 张瑞昌, 等. 综合 ICU 内腹腔感染相关性脓毒症患者的临床特征分析. 国际医药卫生导报, 2018, 24(23): 3604-3606.
13.	Wang L, Chen Q, Yu Q, et al. ITREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis. Inflamm Res, 2021, 70(9): 971-980.
14.	Wang X, Luo B, Lu Y, et al. The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice. Cell Tissue Res, 2018, 374(1): 137-148.
15.	Gonçalves RM, Delgobo M, Agnes JP, et al. COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. Cancer Lett, 2021, 1(502): 44-57.
16.	Xie Y, Li X, Lv D, et al. TREM-1 amplifies trophoblastic inflammation via activating NF-κB pathway during preeclampsia. Placenta, 2021, 115: 97-105.
17.	Tang J, Dong Q, Tang J, et al. Knockdown of TREM-1 suppresses IL-1β-induced chondrocyte injury via inhibiting the NF-κB pathway. Biochem Biophys Res Commun, 2017, 482(4): 1240-1245.
18.	Joung EJ, Cao L, Lee B, et al. Sargahydroquinoic acid, a cyclooxygenase-2 inhibitor, attenuates inflammatory responses by regulating NF-κB inactivation and Nrf2 activation in lipopolysaccharide-stimulated cells. Inflammation, 2021, 44(5): 2120-2131.

1. Blot S, Antonelli M, Arvaniti K, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Med, 2019, 45(12): 1703-1717.
2. Chou EH, Mann S, Hsu TC, et al. Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: a nationwide study. PLoS One, 2020, 15(1): e0227752.
3. 况刚, 陈勇, 魏旭升, 等. 24 h LCR、SOFA 评分及 SAPSⅡ评分在腹腔感染致脓毒症患者预后评估中的作用. 湖南师范大学学报(医学版), 2020, 17(1): 26-29.
4. Qu Z, Zhu Y, Wang M, et al. Prognosis and risk factors of sepsis patients in Chinese ICUs: a retrospective analysis of a cohort database. Shock, 2021, 56(6): 921-926.
5. Dadkhah A, Fatemi F, Rasooli A, et al. Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. Pharm Biol, 2018, 56(1): 495-504.
6. 刘胜蕊, 史晓峰, 王兵, 等. 腹腔感染性脓毒症可溶性髓样细胞触发受体(sTREM-1)与 Janus 激酶-信号转导和转录激活因子(JAK/STAT)通路的关系. 中华急诊医学杂志, 2016, 25(3): 314-319.
7. 李瑞萍, 宋伟. 血浆 sTREM-1、sFLT-1 及 APACHEⅡ评分对重症肺炎患者预后评估价值. 国际呼吸杂志, 2018, 38(13): 968-971.
8. Verma AK, Pandey AK, Singh A, et al. Increased serum levels of matrix-metalloproteinase-9, cyclo-oxygenase-2 and prostaglandin E-2 in patients with chronic obstructive pulmonary disease (COPD). Indian J Clin Biochem, 2022, 37(2): 169-177.
9. 中华医学会外科学分会外科感染与重症医学学组, 中国医师协会外科医师分会肠瘘外科医师专业委员会. 中国腹腔感染诊治指南(2019 版). 中国实用外科杂志, 2020, 40(1): 1-16.
10. 中国医师协会急诊医师分会, 中国研究型医院学会休克与脓毒症专业委员会. 中国脓毒症/脓毒性休克急诊治疗指南(2018). 中国急救医学, 2018, 38(9): 741-756.
11. 魏锋, 洪志敏, 董海涛, 等. ICU 重度脓毒症的流行病学特点及预后影响因素的分析. 中华医院感染学杂志, 2018, 28(10): 1469-1471, 1484.
12. 陶丽丽, 张振辉, 张瑞昌, 等. 综合 ICU 内腹腔感染相关性脓毒症患者的临床特征分析. 国际医药卫生导报, 2018, 24(23): 3604-3606.
13. Wang L, Chen Q, Yu Q, et al. ITREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis. Inflamm Res, 2021, 70(9): 971-980.
14. Wang X, Luo B, Lu Y, et al. The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice. Cell Tissue Res, 2018, 374(1): 137-148.
15. Gonçalves RM, Delgobo M, Agnes JP, et al. COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. Cancer Lett, 2021, 1(502): 44-57.
16. Xie Y, Li X, Lv D, et al. TREM-1 amplifies trophoblastic inflammation via activating NF-κB pathway during preeclampsia. Placenta, 2021, 115: 97-105.
17. Tang J, Dong Q, Tang J, et al. Knockdown of TREM-1 suppresses IL-1β-induced chondrocyte injury via inhibiting the NF-κB pathway. Biochem Biophys Res Commun, 2017, 482(4): 1240-1245.
18. Joung EJ, Cao L, Lee B, et al. Sargahydroquinoic acid, a cyclooxygenase-2 inhibitor, attenuates inflammatory responses by regulating NF-κB inactivation and Nrf2 activation in lipopolysaccharide-stimulated cells. Inflammation, 2021, 44(5): 2120-2131.

Previous Article
Role of chaiqin chengqi decoction on serum lipid metabolism in experimental acute pancreatitis
Next Article
Social phobia and its influencing factors in patients with gastrointestinal neoplasms

West China Medical Journal

Diagnostic and prognostic value of serum soluble triggering receptor expressed on myeloid cell-1 and cyclooxygenase-2 in abdominal infection-caused sepsis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content