Abnormal RNA translation and amyotrophic lateral sclerosis_West China Medical Journal

Authors：

ZHANG Xinyi , SHANG Huifang ,  WEI Qianqian

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WEI Qianqian, Email: 578361552@qq.com

Keywords：

Amyotrophic lateral sclerosis; motor neuron disease; RNA translation; integrated stress response

DOI：

10.7507/1002-0179.202404278

Video：

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Abstract Full text Figures/Tables Video References Cited by

The translation and translation regulation of RNA in eukaryotic cells have a significant impact on cellular gene expression and maintenance of proteomic homeostasis. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects upper and lower motor neurons and leads to muscle weakness and atrophy. More and more studies have found RNA translation abnormalities in ALS. This article provides an overview of RNA translation and regulation in eukaryotic cells under physiological and stress conditions, and explores the relationship between four different ALS-related genes and translation abnormalities, providing new ideas for the treatment of ALS.

Citation： ZHANG Xinyi, SHANG Huifang, WEI Qianqian. Abnormal RNA translation and amyotrophic lateral sclerosis. West China Medical Journal, 2025, 40(5): 827-831. doi: 10.7507/1002-0179.202404278 Copy

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65.
66.
67. Hallegger M, Chakrabarti AM, Lee FCY, et al. TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell, 2021, 184(18): 4680-4696.e22.
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West China Medical Journal

Abnormal RNA translation and amyotrophic lateral sclerosis

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