Relationship between circularRNA oxysterol binding protein-like 2, circularRNA catenin beta 1 and frequent acute exacerbation of patients with stable chronic obstructive pulmonary disease_West China Medical Journal

Authors：

GUO Zhiqiang ,  LIU Yunfeng , TAN Junhui , YANG Bowen , JIAO Jiao

Emergency Department, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, P. R. China;

Corresponding author：

LIU Yunfeng, Email: lyf1005@sohu.com

Keywords：

Chronic obstructive pulmonary disease; frequent acute exacerbations; circularRNA oxysterol binding protein-like 2; circularRNA catenin beta 1; predication

DOI：

10.7507/1002-0179.202406268

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Objective To investigate the relationship between peripheral blood circularRNA oxysterol binding protein-like 2 (circOSBPL2), circularRNA catenin beta 1 (circCTNNB1) and frequent acute exacerbations of patients with stable chronic obstructive pulmonary disease (COPD). Methods Patients with stable COPD admitted to the First Affiliated Hospital of Hebei North University between January 2021 and March 2023 were retrospective selected. Based on the time of acute exacerbations during the 1-year follow-up period, the included patients were divided into the frequent acute exacerbation group and the control group. The expression levels of circOSBPL2 and circCTNNB1 in peripheral blood and the clinical data of the two groups were compared. The influencing factors of frequent acute exacerbations were analyzed by binary logistic multivariate regression, and the predictive value of each indicator for frequent acute exacerbations was analyzed by receiver operator characteristic curve. Results A total of 109 patients were included. Among them, there were 42 cases in the frequent acute exacerbation group and 67 cases in the control group. The expression level of circOSBPL2 in peripheral blood and Chronic Obstructive Pulmonary Disease Assessment Test (CAT) score of patients in the frequent acute exacerbation group were higher than those in the control group (P<0.05), and the expression level of circCTNNB1 in peripheral blood and serum albumin levels were lower than those in the control group (P<0.05). There was no significant difference in other clinical data between the two groups (P>0.05). The results of binary logistic multiple regression analysis showed that circOSBPL2 and CAT score were risk factors for frequent acute exacerbations, and circCTNNB1 was protective a factor for frequent acute exacerbations (P<0.05). The receiver operator characteristic curve analysis results showed that the area under the curve predicted by the combination of circOSBPL2, circCTNNB1, and CAT scores was higher than that predicted by circOSBPL2, circCTNNB1, and CAT scores alone [0.948 (0.907, 0.989) vs. 0.811 (0.733, 0.889) vs. 0.833 (0.758, 0.907) vs. 0.738 (0.640, 0.835), P<0.05]. Conclusions The increase of circOSBPL2 expression and the decrease of circCTNNB1 expression in peripheral blood of stable chronic obstructive pulmonary disease patients are associated with frequent acute exacerbations. CircOSBPL2 and circCTNNB1 combined with CAT score have good predictive value for frequent acute exacerbations.

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11.	Vogelmeier CF, Román-Rodríguez M, Singh D, et al. Goals of COPD treatment: focus on symptoms and exacerbations. Respir Med, 2020, 166: 105938.
12.	Zhao K, Dong R, Yu Y, et al. Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway. Aging (Albany NY), 2020, 12(10): 9125-9138.
13.	Panek I, Liczek M, Gabryelska A, et al. Inflammasome signalling pathway in the regulation of inflammation - its involvement in the development and exacerbation of asthma and chronic obstructive pulmonary disease. Postepy Dermatol Alergol, 2023, 40(4): 487-495.
14.	冼美兰, 王贤君, 李纯香, 等. 稳定期慢性阻塞性肺疾病频繁急性加重的影响因素及其与血清 SFRP1、PGRN 水平的相关性. 临床与病理杂志, 2022, 42(1): 151-158.
15.	冯秀敏, 葛海燕, 戈霞晖, 等. 上海地区三甲医院频繁与非频繁急性加重稳定期 COPD 患者的临床特征差异及其临床意义. 国际呼吸杂志, 2020, 40(5): 327-335.
16.	李建英, 刘远程, 潘杨. 8-异前列腺素 F2α和白细胞介素-17 预测慢性阻塞性肺疾病稳定期患者急性发作的作用. 医学研究生学报, 2022, 35(8): 863-867.
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1. Zhu D, Dai H, Zhu H, et al. Identification of frequent acute exacerbations phenotype in COPD patients based on imaging and clinical characteristics. Respir Med, 2023, 209: 107150.
2. Christenson SA. COPD Phenotyping. Respir Care, 2023, 68(7): 871-880.
3. Wu JJ, Xu HR, Zhang YX, et al. The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review. BMC Pulm Med, 2020, 20(1): 103.
4. Whittaker H, Rubino A, Müllerová H, et al. Frequency and severity of exacerbations of COPD associated with future risk of exacerbations and mortality: a UK routine health care data study. Int J Chron Obstruct Pulmon Dis, 2022, 17: 427-437.
5. Yang H, Wen X, Wu F, et al. Inter-relationships among neutrophilic inflammation, air trapping and future exacerbation in COPD: an analysis of ECOPD study. BMJ Open Respir Res, 2023, 10(1): e001597.
6. Zheng C, Zhang Y, Zhao Y, et al. Circ-OSBPL2 contributes to smoke-related chronic obstructive pulmonary disease by targeting miR-193a-5p/BRD4 axis. Int J Chron Obstruct Pulmon Dis, 2021, 16: 919-931.
7. Chen C, Chang X, Zhang S, et al. CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression. Bioengineered, 2022, 13(4): 10258-10273.
8. Qi J, Wang T, Zhang Z, et al. Circ-ctnnb1 regulates neuronal injury in spinal cord injury through the Wnt/beta-catenin signaling pathway. Dev Neurosci, 2022, 44(3): 131-141.
9. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013 年修订版). 中华结核和呼吸杂志, 2013, 36(4): 255-264.
10. Bhatt SP, Agusti A, Bafadhel M, et al. Phenotypes, etiotypes, and endotypes of exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2023, 208(10): 1026-1041.
11. Vogelmeier CF, Román-Rodríguez M, Singh D, et al. Goals of COPD treatment: focus on symptoms and exacerbations. Respir Med, 2020, 166: 105938.
12. Zhao K, Dong R, Yu Y, et al. Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway. Aging (Albany NY), 2020, 12(10): 9125-9138.
13. Panek I, Liczek M, Gabryelska A, et al. Inflammasome signalling pathway in the regulation of inflammation - its involvement in the development and exacerbation of asthma and chronic obstructive pulmonary disease. Postepy Dermatol Alergol, 2023, 40(4): 487-495.
14. 冼美兰, 王贤君, 李纯香, 等. 稳定期慢性阻塞性肺疾病频繁急性加重的影响因素及其与血清 SFRP1、PGRN 水平的相关性. 临床与病理杂志, 2022, 42(1): 151-158.
15. 冯秀敏, 葛海燕, 戈霞晖, 等. 上海地区三甲医院频繁与非频繁急性加重稳定期 COPD 患者的临床特征差异及其临床意义. 国际呼吸杂志, 2020, 40(5): 327-335.
16. 李建英, 刘远程, 潘杨. 8-异前列腺素 F2α和白细胞介素-17 预测慢性阻塞性肺疾病稳定期患者急性发作的作用. 医学研究生学报, 2022, 35(8): 863-867.
17. Cosío BG, Shafiek H, Verdú J, et al. Implementation of an integrated care model for frequent-exacerbator COPD patients: a controlled prospective study. Arch Bronconeumol (Engl Ed), 2021: S0300-2896(21)00050-8.

West China Medical Journal

Latest ArticlesRelationship between circularRNA oxysterol binding protein-like 2, circularRNA catenin beta 1 and frequent acute exacerbation of patients with stable chronic obstructive pulmonary disease

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