Epidemiological status and trends of colorectal cancer in China and the United States_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Lin ¹ , LI Xu ¹ , TAN Kun ² , DENG Ren ² , GAO Linna ³ ,  WANG Xiaodong ⁴

1. Center of Biostatistics, Design, Measurement and Evaluation (CBDME), Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Sichuan Provincial Health Information Center, Chengdu 610041, P. R. China;
3. Department of Gastrointestinal Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030000, P. R. China;
4. Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

colorectal cancer; incidence; mortality; prevention

DOI：

10.7507/1007-9424.202505086

Video：

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Objective To compare the epidemiological status and trends of colorectal cancer in China and the United States, and to summarize the respective prevention and screening strategies. Methods Based on relevant data such as the Global cancer statistics (2022), Cancer statistics (2025), the China Cancer Burden of Disease Report (2022), and the China-United States colorectal cancer epidemiology report, the incidence, mortality and trends of colorectal cancer in China and the United States were analyzed. Results From 2000 to 2018, age-standardized incidence rate of colorectal cancer in China increased by an average of 2.7% per year for men and 1.1% per year for women, with an average annual mortality increase of 1.2% for men and a decrease of 0.3% per year for women. Colorectal cancer mortality decreased by an average of 1.2% per year in the United States in 2011–2021 and by an average of 1.7% per year in 2013–2022, and the 5-year relative survival rate for colorectal cancer increased from 50% in 1975–1977 to 64% in 2014–2020. Conclusions The incidence and mortality of colorectal cancer in the United States have shown a downward trend, and the survival rate of patients is increasing. The situation in our country is different: the incidence continues to rise, the mortality is higher than the United States, and although the survival rate has improved, it is still not at the level of the United States. China continues to face a heavy burden of colorectal cancer. To enhance colorectal cancer prevention and treatment, it is essential to establish a new multi-stakeholder collaborative framework for disease control, ultimately forming a colorectal cancer management system with Chinese characteristics, thereby effectively reducing the national colorectal cancer disease burden.

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2.	Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022. J Natl Cancer Cent, 2024, 4(1): 47-53.
3.	Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025. CA Cancer J Clin, 2025, 75(1): 10-45.
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6.	Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
7.	Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
8.	Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
9.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
10.	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
11.	王裕新, 潘凯枫, 李文庆. 2022全球癌症统计报告解读. 肿瘤综合治疗电子杂志, 2024, 10(3): 1-16.
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14.	Chen WQ, Zeng HM, Zheng RS, et al. Cancer incidence and mortality in China, 2007. Chin J Cancer Res, 2012, 24(1): 1-8.
15.	Chen W, Zheng R, Zhang S, et al. Cancer incidence and mortality in China, 2013. Cancer Lett, 2017, 401: 63-71.
16.	Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014. Chin J Cancer Res, 2018, 30(1): 1-12.
17.	赵文静, 尹周一, 王裕新, 等. 2024美国癌症统计报告解读及中美癌症流行情况对比. 肿瘤防治研究, 2024, 51(8): 630-641.
18.	尹周一, 王梦圆, 游伟程, 等. 2022美国癌症统计报告解读及中美癌症流行情况对比. 肿瘤综合治疗电子杂志, 2022, 8(2): 54-63.
19.	黄理宾, 黄秋实, 杨烈. 全球及中国的结直肠癌流行病学特征及防治: 2022《全球癌症统计报告》解读. 中国普外基础与临床杂志, 2024, 31(5): 530-537.
20.	张金珠, 杨明, 王锡山. 中国、美国及世界结直肠癌流行病学与疾病负担的对比和思考. 中华结直肠疾病电子杂志, 2024, 13(2): 89-93.
21.	王锡山. 从中美结直肠癌流行病学特征看结直肠癌早诊早治的重要性. 中华结直肠疾病电子杂志, 2021, 10(1): 26-33.
22.	胡志强, 游伟程, 潘凯枫, 等. 中、美两国癌症流行特征分析—《2023美国癌症统计报告》解读. 科技导报, 2023, 41(18): 18-28.
23.	练佳韦, 刘颖春, 余红平. 结直肠癌的全球流行情况、危险因素及归因疾病负担研究进展. 中国癌症防治杂志, 2024, 16(1): 1-9.
24.	郭兰伟, 张兴龙, 蔡林, 等. 全球结直肠癌流行和防控现状. 中华肿瘤杂志, 2024, 46(1): 57-65.
25.	中华医学会肿瘤学分会早诊早治学组. 中国结直肠癌早诊早治专家共识 (2023版). 中华普通外科学文献 (电子版), 2024, 18(1): 1-13.
26.	郑莹, 王泽洲. 全球结直肠癌流行数据解读. 中华流行病学杂志, 2021, 42(1): 149-152.

1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
2. Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022. J Natl Cancer Cent, 2024, 4(1): 47-53.
3. Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025. CA Cancer J Clin, 2025, 75(1): 10-45.
4. Siegel RL, Wagle NS, Cercek A, et al. Colorectal cancer statistics, 2023. CA Cancer J Clin, 2023, 73(3): 233-254.
5. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin, 1999, 49(1): 33-64.
6. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
7. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
8. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
9. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
10. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
11. 王裕新, 潘凯枫, 李文庆. 2022全球癌症统计报告解读. 肿瘤综合治疗电子杂志, 2024, 10(3): 1-16.
12. 郑荣寿, 陈茹, 韩冰峰, 等. 2022年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2024, 46(3): 221-231.
13. Chen WQ, Zhang SW, Zou XN, et al. Cancer incidence and mortality in China, 2006. Chin J Cancer Res, 2011, 23(1): 3-9.
14. Chen WQ, Zeng HM, Zheng RS, et al. Cancer incidence and mortality in China, 2007. Chin J Cancer Res, 2012, 24(1): 1-8.
15. Chen W, Zheng R, Zhang S, et al. Cancer incidence and mortality in China, 2013. Cancer Lett, 2017, 401: 63-71.
16. Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014. Chin J Cancer Res, 2018, 30(1): 1-12.
17. 赵文静, 尹周一, 王裕新, 等. 2024美国癌症统计报告解读及中美癌症流行情况对比. 肿瘤防治研究, 2024, 51(8): 630-641.
18. 尹周一, 王梦圆, 游伟程, 等. 2022美国癌症统计报告解读及中美癌症流行情况对比. 肿瘤综合治疗电子杂志, 2022, 8(2): 54-63.
19. 黄理宾, 黄秋实, 杨烈. 全球及中国的结直肠癌流行病学特征及防治: 2022《全球癌症统计报告》解读. 中国普外基础与临床杂志, 2024, 31(5): 530-537.
20. 张金珠, 杨明, 王锡山. 中国、美国及世界结直肠癌流行病学与疾病负担的对比和思考. 中华结直肠疾病电子杂志, 2024, 13(2): 89-93.
21. 王锡山. 从中美结直肠癌流行病学特征看结直肠癌早诊早治的重要性. 中华结直肠疾病电子杂志, 2021, 10(1): 26-33.
22. 胡志强, 游伟程, 潘凯枫, 等. 中、美两国癌症流行特征分析—《2023美国癌症统计报告》解读. 科技导报, 2023, 41(18): 18-28.
23. 练佳韦, 刘颖春, 余红平. 结直肠癌的全球流行情况、危险因素及归因疾病负担研究进展. 中国癌症防治杂志, 2024, 16(1): 1-9.
24. 郭兰伟, 张兴龙, 蔡林, 等. 全球结直肠癌流行和防控现状. 中华肿瘤杂志, 2024, 46(1): 57-65.
25. 中华医学会肿瘤学分会早诊早治学组. 中国结直肠癌早诊早治专家共识 (2023版). 中华普通外科学文献 (电子版), 2024, 18(1): 1-13.
26. 郑莹, 王泽洲. 全球结直肠癌流行数据解读. 中华流行病学杂志, 2021, 42(1): 149-152.

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