Objective To investigate the clinical efficacy of CoughAssist for cleaning airway secretions in neuromuscular disease patients with respiratory insufficiency.
Methods Forty-six cases of neuromuscular disease with respiratory insufficiency were recruited in the study,with Guillain-Barre syndrome in 24 cases,myasthenia gravis in 18 cases,and multiple myositis in 4 patients.Thirty-four patients underwent intubation and mechanical ventilation,and 12 patients underwent tracheotomy.They were randomly divided into group A using CoughAssist and group B using suction tube to clear airway secretions after mechanical vibration.The frequency of suction within 24 hours,oxygenation index,pulmonary static compliance,incidence of lung infections,lung auscultation and chest radiograph were recorded and compared between two groups.
Results CoughAssist could more effectively clean respiratory secretions with higher oxygenation index and pulmonary static compliance in group A.Lung auscultation and chest radiograph significantly improved,and the incidence of lung infection significantly decreased in group A compared with group B.Furthermore,CoughAssist reduced nursing workload with lower frequency of suction within 24 hours.
Conclusion CoughAssist can effectively clean up airway secretions,improve oxygenation,while reducing pulmonary infection and nursing workload for neuromuscular disease patients with respiratory insufficiency,so it is aworthy tool in clincal practice.
Citation：
YueWeigang, ZhangZhigang, MaFangli, LiBin. Clinical Efficacy of CoughAssist for Cleaning Airway Secretions in Neuromuscular Disease Patients with Respiratory Insufficiency. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(6): 588-590. doi: 10.7507/1671-6205.2014143
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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- 1. Rajabally YA.Treatment of Guillain-Barré syndrome:a review.Inflamm Allergy Drug Targets,2012,11:330-334.
- 2. 符晓艳.格林巴利综合症呼吸道管理的研究进展.现代医药卫生,2008,24:370-371.
- 3. Schmidt I.Assisted cough--physiotherapy to improve expectoration of mucus.Pneumologie,2008,62 Suppl 1:S23-S27.
- 4. Panitch HB.Airway clearance in children with neuromuscular weakness.Curr Opin Pediatr,2006,18:277-281.
- 5. 朱蕾,钮善福,主编.机械通气.第2版.上海:上海科学技术出版社,2007.
- 6. Homnick DN.Mechanical insufflation-exsufflation for airway mucus clearance.Respir Care,2007,52:1296-1305.
- 7. 王保国,周建新,主编.实用呼吸机治疗学.第2版.北京:人民卫生出版社,2005,242.
- 8. 岳伟岗,张志刚,李永刚,等.CoughAssist用于清理吉兰-巴雷综合征患者气道分泌物的效果.广东医学,2012,33:3836-3837.
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