Therapeutic efficacy of GM-CSF inhalation in patients with recurrent pulmonary alveolar proteinosis_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 LI Ying , LIU Lang , ZHANG Xiaohua , LUO Guangming , YAN Wei , YANG Long

Hunan Prevention and Treatment Central for Occupational Diseases, Changsha, Hunan 410007, P.R.China;

Corresponding author：

LI Ying, Email: liying9858@163.com

Keywords：

Pulmonary alveolar proteinosis; Recurrent; Granulocyte-macrophage colony-stimulating factor; Inhalation

DOI：

10.7507/1671-6205.201608008

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate therapeutic efficacy and safety of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation in patients with recurrent pulmonarv alveolar proteinosis (PAP). Methods Three cases of recurrent PAP were treated by GM-CSF inhalation after whole lung lavage. The clinical data of the pulmonary function and SpO ₂, the clinical symptoms and pulmonary lesions were compared before and after treatment. Results The pulmonary function and manifestations were improved obviously after GM-CSF inhalation. Also the ground-glass opacity was improved in high-resolution CT. The pulmonary function and SpO ₂ increased obviously after received GM-CSF inhalation. There were no any adverse reactions in 3 cases. Conclusion GM-CSF inhalation therapy is effective and safe in recurrent PAP, but the long-term effect remains to be seen.

Citation： LI Ying, LIU Lang, ZHANG Xiaohua, LUO Guangming, YAN Wei, YANG Long. Therapeutic efficacy of GM-CSF inhalation in patients with recurrent pulmonary alveolar proteinosis. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(3): 271-273. doi: 10.7507/1671-6205.201608008 Copy

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7.	王婷, 张杰, 王娟, 等. 全肺灌洗联合皮下注射粒细胞巨噬细胞集落刺激因子治疗肺泡蛋白沉积症一例. 中华结核和呼吸杂志, 2010, 33(12): 947-949.
8.	Venkateshiah SB, Yah TD, Bonfield TL, et al. An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis. Chest, 2006, 130(1): 227-237.
9.	高天敏. 大容量全肺灌洗联合皮下注射重组人粒细胞-巨噬细胞集落刺激因子治疗肺泡蛋白沉积症一例报道. 中国呼吸与危重监护杂志, 2014, 13(1): 89-91.
10.	Wylam ME, Ten R, Prakash UB, et al. Aerosol granulocytemaerophage colony-stimulating factor for pulmonary alveolar proteinosis. Eur Respir J, 2006, 27(3): 585-593.
11.	郭文亮, 曾运祥, 苏柱泉, 等. 粒细胞-巨噬细胞集落刺激因子雾化吸入治疗自身免疫性肺泡蛋白沉积症一例并文献复习. 中华结核和呼吸杂志, 2015, 38(10): 751-755.
12.	陈红波, 张承云, 程德云, 等. 特发性肺泡蛋白沉积症全肺灌洗和粒细胞-巨噬细胞集落刺激因子吸入治疗疗效观察. 临床内科杂志, 2010, 27(3): 168-170.

1. Ioachimescu OC, Karuru MS. Pulmonary alveolar proteinosis. Chron Respire Dis, 2006, 3(3): 149-159.
2. Tazawa R, Trapnell BC, Inoue Y, et al. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. Am J Respir Crit Care Med, 2010, 181(12): 1345-1354.
3. 朱元珏, 陈文彬. 呼吸病学. 北京: 人民卫生出版社, 2002, 1106-1111.
4. 徐萧洪, 宋作庆, 范贤明. 肺泡蛋白沉积症的研究进展. 国际呼吸杂志, 2006, 26(11): 856-859.
5. 李颖, 严薇, 张晓华, 等. 肺泡蛋白沉积症 34 例临床诊治分析. 中国呼吸与危重监护杂志, 2016, 15(4): 398-400.
6. 沈毅弘, 赵琼, 陆国华, 等. 粒细胞-巨噬细胞集落刺激因子治疗特发性肺泡蛋白沉积症一例. 中华结核和呼吸杂志, 2009, 32(1): 62-63.
7. 王婷, 张杰, 王娟, 等. 全肺灌洗联合皮下注射粒细胞巨噬细胞集落刺激因子治疗肺泡蛋白沉积症一例. 中华结核和呼吸杂志, 2010, 33(12): 947-949.
8. Venkateshiah SB, Yah TD, Bonfield TL, et al. An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis. Chest, 2006, 130(1): 227-237.
9. 高天敏. 大容量全肺灌洗联合皮下注射重组人粒细胞-巨噬细胞集落刺激因子治疗肺泡蛋白沉积症一例报道. 中国呼吸与危重监护杂志, 2014, 13(1): 89-91.
10. Wylam ME, Ten R, Prakash UB, et al. Aerosol granulocytemaerophage colony-stimulating factor for pulmonary alveolar proteinosis. Eur Respir J, 2006, 27(3): 585-593.
11. 郭文亮, 曾运祥, 苏柱泉, 等. 粒细胞-巨噬细胞集落刺激因子雾化吸入治疗自身免疫性肺泡蛋白沉积症一例并文献复习. 中华结核和呼吸杂志, 2015, 38(10): 751-755.
12. 陈红波, 张承云, 程德云, 等. 特发性肺泡蛋白沉积症全肺灌洗和粒细胞-巨噬细胞集落刺激因子吸入治疗疗效观察. 临床内科杂志, 2010, 27(3): 168-170.

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Chinese Journal of Respiratory and Critical Care Medicine

Therapeutic efficacy of GM-CSF inhalation in patients with recurrent pulmonary alveolar proteinosis

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