Mental Intervention for Cancer Patients with Depression: A Systematic Review of Randomized Controlled Trials_Chinese Journal of Evidence-Based Medicine

Authors：

JIANGXiaomei, MI Denghai, WANG Hongquan, ZHANG Lan

1. Oncology Treatment Center, the Second People’s Hospital of Gansu Province, Lanzhou 730000, China; 2. The Second Hospital of Lanzhou university, Lanzhou 730000, China;

Corresponding author：

Keywords：

Psychotherapy; Cancer; Depression; Meta analysis

DOI：

10.7507/1672-2531.20100408

Video：

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Objective 　To systematically evaluate the effects of psychotherapy for cancer patients with depression.
Methods 　We searched The Cochrane Library, PubMed, EMbase, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, and Chinese Journal Full-text Database up to October 2010 to identify randomized controlled trials (RCTs) comparing psychotherapy plus conventional treatment with conventional treatment alone. The data were analyzed by using RevMan 5.0 software.
Results 　Eleven RCTs involving 1 670 participants were included. The results of meta-analyses showed: (1) A significant difference was found between psychotherapy plus conventional treatment and conventional treatment alone in decrease of depression score (SMD= – 0.40, 95%CI – 0.70 to – 0.11); (2) No difference was observed between the two groups in decrease of anxiety score (SMD= – 0.68, 95%CI – 1.37 to 0.01), but the result was changed when a sensitivity analysis was done (SMD= – 0.30, 95%CI – 0.52 to -0.08).
Conclusion 　Compared with conventional treatment alone, psychotherapy combined with conventional treatment could improve depressive states in cancer patients, but the result still needs to be confirmed by high-quality and large-sample RCTs.

Citation： JIANG Xiaomei,MI Denghai,WANG Hongquan,ZHANG Lan. Mental Intervention for Cancer Patients with Depression: A Systematic Review of Randomized Controlled Trials. Chinese Journal of Evidence-Based Medicine, 2010, 10(3): 352-355. doi: 10.7507/1672-2531.20100408 Copy

1.	Derogatis LR, Morrow GR, Fetting J, et al. The prevalence of psychiatric disorders among cancer patients. JAMA, 1983, 249(6): 751-757.
2.	Pascoe S, Edelman S, Kidman A, et al. Prevalence of psychological distress and use of support service by cancer patient at Sydney hospital. Aust N ZJ Psychiatry, 2000, 34(5): 785-791.
3.	Zabora J, BrintzenhofeSzoc K, Crubow B, et al. The prevalence of psychological distress by cancer site. Psychooncology, 2001, 10(1): 19-28.
4.	Koenig HG, Gohen HJ, Blazer DG, et al. Brief depression scale for use in the medically ill. Int J Psychiatry Med, 1992, 22(2): 183-195.
5.	Okuyama T, Nakane Y, Endo C, et al. Mental health literacy in Japanese cancer patients: ability to recognize depression and preferences of treatments-comparison with Japanese lay public. Psychooncology, 2007, 16(9): 834-842.
6.	Zung WW. A self-Rating depression scale. Arch Gen Psychiatry, 1965, 12(1): 63-70.
7.	Zung WW. A rating instrument for anxiety disorders. Psychosomatics, 1971, 12(6): 371-379.
8.	Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available at: www.cochrane handbook. org.
9.	Spiegel D, Bloom JR, Yalom I. Group support for patients with metastatic cancer. A randomized outcome study. Arch Gen Psychiatry, 1981, 38(5): 527-533.
10.	Linn MW, Linn BS, Harris R. Effects of counseling for late stage cancer patients. Cancer, 1982, 49(5): 1048-1055.
11.	Wood BC, Mynors-Wallis LM. Problem-solving therapy in palliative care. Palliat Med, 1997, 11(1): 49-54.
12.	Edelman S, Bell DR, Kidman AD. A group cognitive behaviour therapy programme with metastatic breast cancer patients. Psychooncology, 1999, 8(4): 295-305.
13.	Classen C, Butler LD, Koopman C, et al. Supportive-expressive group therapy and distress in patients with metastatic breast cancer: a randomized clinical intervention trial. Arch Gen Psychiatry, 2001, 58(5): 494-501.
14.	Goodwin PJ, Leszcz M, Ennis M, et al. The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med, 2001, 345(24): 1719-1726.
15.	Liossi C, White P. Efficacy of clinical hypnosis in the enhancement of quality of life of terminally ill cancer patients. Contemp Hypn, 2001, 18(3): 145-160.
16.	Wu L, Wang S. Psychotherapy improving depression and anxiety of patients treated with chemotherapy combined with radiotherapy. Chinese Journal of Clinical Rehabilitation, 2003, 7(17): 2462-2463.
17.	Laidlaw T, Bennett BM, Dwivedi P, et al. Quality of life and mood changes in metastatic breast cancer after training in self-hypnosis or johrei: a short report. Contemp Hypn, 2005, 22(2): 84-93.
18.	Wilkinson SM, Love SB, Westcombe AM, et al. Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer: a multicenter randomized controlled trial. J Clin Oncol, 2007, 25(5): 532-539.
19.	Pitceathly C, Maguire P, Fletcher I, et al. Can a brief psychological intervention prevent anxiety or depressive disorders in cancer patients? A randomised controlled trial. Ann Oncol, 2009, 20(5): 928-934.
20.	Bech P, Cialdella P, Haugh MC, et al. Meta-analysis of randomised controlled trials of fluoxetine versus placebo and tricyclic antidepressants in the short-term treatment of major depression. Br J Psychiatry, 2000, 176 (1): 421-428.
21.	Word Health Organization. The world health report 2001. Mental health: new understanding, new hope. [2001-11-01]. http: //www. who. int/whr,.

1. Derogatis LR, Morrow GR, Fetting J, et al. The prevalence of psychiatric disorders among cancer patients. JAMA, 1983, 249(6): 751-757.
2. Pascoe S, Edelman S, Kidman A, et al. Prevalence of psychological distress and use of support service by cancer patient at Sydney hospital. Aust N ZJ Psychiatry, 2000, 34(5): 785-791.
3. Zabora J, BrintzenhofeSzoc K, Crubow B, et al. The prevalence of psychological distress by cancer site. Psychooncology, 2001, 10(1): 19-28.
4. Koenig HG, Gohen HJ, Blazer DG, et al. Brief depression scale for use in the medically ill. Int J Psychiatry Med, 1992, 22(2): 183-195.
5. Okuyama T, Nakane Y, Endo C, et al. Mental health literacy in Japanese cancer patients: ability to recognize depression and preferences of treatments-comparison with Japanese lay public. Psychooncology, 2007, 16(9): 834-842.
6. Zung WW. A self-Rating depression scale. Arch Gen Psychiatry, 1965, 12(1): 63-70.
7. Zung WW. A rating instrument for anxiety disorders. Psychosomatics, 1971, 12(6): 371-379.
8. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available at: www.cochrane handbook. org.
9. Spiegel D, Bloom JR, Yalom I. Group support for patients with metastatic cancer. A randomized outcome study. Arch Gen Psychiatry, 1981, 38(5): 527-533.
10. Linn MW, Linn BS, Harris R. Effects of counseling for late stage cancer patients. Cancer, 1982, 49(5): 1048-1055.
11. Wood BC, Mynors-Wallis LM. Problem-solving therapy in palliative care. Palliat Med, 1997, 11(1): 49-54.
12. Edelman S, Bell DR, Kidman AD. A group cognitive behaviour therapy programme with metastatic breast cancer patients. Psychooncology, 1999, 8(4): 295-305.
13. Classen C, Butler LD, Koopman C, et al. Supportive-expressive group therapy and distress in patients with metastatic breast cancer: a randomized clinical intervention trial. Arch Gen Psychiatry, 2001, 58(5): 494-501.
14. Goodwin PJ, Leszcz M, Ennis M, et al. The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med, 2001, 345(24): 1719-1726.
15. Liossi C, White P. Efficacy of clinical hypnosis in the enhancement of quality of life of terminally ill cancer patients. Contemp Hypn, 2001, 18(3): 145-160.
16. Wu L, Wang S. Psychotherapy improving depression and anxiety of patients treated with chemotherapy combined with radiotherapy. Chinese Journal of Clinical Rehabilitation, 2003, 7(17): 2462-2463.
17. Laidlaw T, Bennett BM, Dwivedi P, et al. Quality of life and mood changes in metastatic breast cancer after training in self-hypnosis or johrei: a short report. Contemp Hypn, 2005, 22(2): 84-93.
18. Wilkinson SM, Love SB, Westcombe AM, et al. Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer: a multicenter randomized controlled trial. J Clin Oncol, 2007, 25(5): 532-539.
19. Pitceathly C, Maguire P, Fletcher I, et al. Can a brief psychological intervention prevent anxiety or depressive disorders in cancer patients? A randomised controlled trial. Ann Oncol, 2009, 20(5): 928-934.
20. Bech P, Cialdella P, Haugh MC, et al. Meta-analysis of randomised controlled trials of fluoxetine versus placebo and tricyclic antidepressants in the short-term treatment of major depression. Br J Psychiatry, 2000, 176 (1): 421-428.
21. Word Health Organization. The world health report 2001. Mental health: new understanding, new hope. [2001-11-01]. http: //www. who. int/whr,.

Chinese Journal of Evidence-Based Medicine

Mental Intervention for Cancer Patients with Depression: A Systematic Review of Randomized Controlled Trials

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