Objective To comparatively analyze risk factors that influence the postoperative recurrence and distant metastasis between Xinjiang Uygur and Han women with breast cancer.
Methods The clinical data of Han and Uyghur women with diagnosis of breast cancer at Ⅰ-Ⅲ period were completely collected for retrospective analysis. Then logistic regression (univariate and multivariate) was performed for analyzing the risk factors that influenced recurrence and metastasis.
Results A total of 728 patients were included. The recurrence and metastasis rates among Uyghur and Han patients 3 years after surgery were 28.4%, 9.8%, respectively, including local recurrence[11 Uyghur cases (6.5%) and 9 Han cases (1.6%)] and distant metastasis[37 Uyghur cases (21.8%) and 45 Han cases (8.0%)]. Significant differences were found between the two groups in tumour size and time from symptom occurrence to clinical visits (P<0.05). Pathological type, tumour size, axillary lymph node metastasis, clinical stage, ER and PR expression, and whether to accept a regular postoperative adjuvant therapy were associated with the recurrence and metastasis rate among the patients with breast cancer at Ⅰ-Ⅲ period (P<0.05). The results of multivariate logistic regression analysis showed that, the recurrence and metastasis rate of Uyghur patients was higher than that of Han patients with a significant difference (P<0.01). Pathological type, tumour size, and axillary lymph node metastasis number were the risk factors used to predict postoperative recurrence and metastasis among Uygur and Han patients; while ER positive expression, adjuvant radiation and postoperative chemotherapy were protective factors.
Conclusion The recurrence and metastasis rate of Uyghur patients with breast cancer is higher than that of Han patients. Pathological type, tumour size, and axillary lymph node metastasis number are the risk factors of postoperative recurrence and distant metastasis; while ER positive expression, adjuvant radiation and postoperative chemotherapy may inhibit the recurrence and distant metastasis of breast cancer.
Citation：
LVWei-wei, LIUChun-sheng, MABin-lin, AliBiyaTi·Aini. Risk Factors of Recurrence and Metastasis between Xinjiang Uygur and Han Women with Breast Cancer: A Comparative Analysis. Chinese Journal of Evidence-Based Medicine, 2015, 15(1): 8-11. doi: 10.7507/1672-2531.20150004
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
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- 1. 杨景明, 邓为民. 保乳术后复发性乳腺癌的治疗进展. 医学综述, 2011, 17(15):2219-2293.
- 2. Yu K, Lee CH. Conservation of breast cancer molecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations. Clin Cancer Res, 2004, 10:5508-5517.
- 3. 沈镇宙, 韩企夏, 邵志敏, 等. 乳腺癌肿瘤体积淋巴结情况与预后的关系. 中华外科杂志, 1991, 29(6):554.
- 4. Komoike Y, Akiyama F, Iino Y. Analysis of ipsilateral breast tumor recurrences after breast-conserving treatment based on the classification of true recurrences and new primary tumors. Breast Cancer, 2005, 12(2):104-111.
- 5. Diab SG, Elledge RM, Clark GM. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Nail Cancer Inst, 2000, 92:550-556.
- 6. Muller A G, Van Zyl JA, Joubert G. Analysis of prognostic factors in 568 patients treated for breast cancer by surgery. J Surg Oncol, 1989, 42(2):126-131.
- 7. Kiyoto S,Hara F, Osumi S, et al. A case of recurrent breast cancer with extensive liver metastasis successfully treated with endocrine therapy. Gan To Kagaku Ryoho, 2009, 36(13):2623-2625.
- 8. Staaf J, Ringner M, Vallon-Christersson J, et al. Identification of subtypes in human epidermal growth factor receptor 2-positive breast cancer reveals a gene signature prognostic of outcome. J Clin Oncol, 2010, 28(11):1813-1820.
- 9. Anderon BO, Senie RT, Vetto JT, et al. Improved survival in young women with breast cancer. Ann Surg Oncol, 1995, 2(5):407-415.
- 10. 丁锦辉, 黄先国, 于冰, 等. 新疆维吾尔族女性乳腺癌临床病理特点与预后分析. 肿瘤研究与临床, 2006, 18:550-552.
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