Effects of Shenlingcao Oral Liquid on 64 Asymptomatic Chronic Hepatitis B Virus Carriers: A Self Control Before-after Trial_Chinese Journal of Evidence-Based Medicine

Authors：

 ZHAOHai-ping , CHENHe-li , LIUHong-ning , KANGLin-zhi , WANGPing , ZHUYi-min ,  ZHUWei-feng

Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;

Corresponding author：

ZHUWei-feng, Email: zef0322@126.com

Keywords：

Shenlingcao oral liquid; Chronic asymptomatic HBV carrier; Self control before-after trial

DOI：

10.7507/1672-2531.20150022

Video：

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Objective To observe intervention effect of Shenlingcao oral liquid on asymptomatic chronic hepatitis B virus carriers (AsC). Methods A self control before-after trial was conducted in the First Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine and the Ninth People's Hospital of Nanchang City from November 2011 to May 2012. A total of 64 AsCs were treated by Shenlingcao oral liquid (1 bottle/d, 200 mL, once daily for 6 months). Serum HBV viral load, six specific serum markers of HBV and 11 liver function index were tested and recorded before and at the 1^th, 3^th, 6^th months of the treatment. Analysis of variance of repeated data was conducted. Results After one month of the treatment, 35/57 (61.40%) AsCs' serum HBV-DNA loads decreased, 1 log decrease was observed in 15 cases, 2 log decrease was observed in 4 cases, and decrease under the detection limit was observed in 12 cases. 41/57 (71.93%) AsCs' serum HBV-DNA loads decreased after 3 months of treatment, 1 log decrease was observed in 21 cases, 2 log decrease was observed in 5 cases, and decrease under the detection limit was observed in 15 cases. 31/49 (63.26%) AsCs' serum HBV-DNA loads decreased after 6 months of the treatment, 1 log decrease was observed in 19 cases, decrease more than 2 log was observed in 7 cases, and decrease under the detection limit was observed in 12 cases. The serum HBV viral loads at different time points of the treatment were significantly different (P<0.001). As medication time went, AsCs' serum HBV viral loads presented a decrease trend after taking Shenlingcao oral liquid, especially obvious at the 3^th month. Conclusion Shenlingcao oral liquid could help promote AsCs' ability of clearing virus and controlling serum HBVDNA loads.

Citation： ZHAOHai-ping, CHENHe-li, LIUHong-ning, KANGLin-zhi, WANGPing, ZHUYi-min, ZHUWei-feng. Effects of Shenlingcao Oral Liquid on 64 Asymptomatic Chronic Hepatitis B Virus Carriers: A Self Control Before-after Trial. Chinese Journal of Evidence-Based Medicine, 2015, 15(2): 125-129. doi: 10.7507/1672-2531.20150022 Copy

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1. 中华人民共和国卫生部. 卫生部公布2006年全国人群乙肝血清流行病学调查结果(2008-4-21)[2013-09-03].
2. 于丽妍, 卢秉久. 中医防治无症状乙肝病毒携带者. 实用中医内科杂志, 2013, 27(10):90-91.
3. 陈大明. 乙肝防治的情报学研究. 中国科学院研究生院(上海生命科学研究院), 2007.
4. 吴芬芬, 吴国营. 近十年乙肝病毒携带者的中医治疗概况与展望. 环球中医药, 2009, 2(5):390-395.
5. 曲桂玉. 慢性无症状乙肝病毒携带者的健康教育. 卫生职业教育, 2005, 23(1):110-112.
6. 施伯安, 崔丽安, 邵凤珍, 等. 健脾益肾法治疗慢性乙肝病毒携带者100例. 中西医结合肝病杂志, 2010, 20(1):45-46.
7. 蒋瑞. 论《内经》"治未病"及其与未来中医走向的关系. 光明中医, 2000, 15(2):9-11.
8. 刘德山.《金匮要略》"治未病"思想探析. 山东医科大学学报社会科学版,1999,(1):46-47.
9. 王非, 刘林, 王媛. 内经治未病的基本涵义. 中医药学报, 1996, (1):6-7.
10. 中华医学会肝病学分会、感染病学分会. 慢性乙型肝炎防治指南. 中华肝脏病杂志, 2005, 12(13):881-889.
11. 当知百科·乙肝病毒携带者. Available at:http://baike.dangzhi.com/wiki/乙肝病毒携带者.
12. 廖振贤. 中医治未病思想治疗无症状乙肝病毒携带者的临床研究. 广州中医药大学硕士学位论文, 2006, 5.
13. 尹雪萍. 论未病和未病学说. 山东中医学院学报, 1993, 17(3):45-47.
14. 苏勋庄. "老年病"并非"老年"病. 山东中医药大学学报, 1999, 23(3):181-183.
15. 宋为民. "未病"现代观. 南京中医学院学报, 1995, 11(1):4-6.
16. 陈晓凡, 朱卫丰, 陈和利, 等. 参灵草口服液治疗无症状HIV感染者疗效的自身前后对照研究. 中国循证医学杂志, 2014, 14(11):1299-1303.

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Chinese Journal of Evidence-Based Medicine

Effects of Shenlingcao Oral Liquid on 64 Asymptomatic Chronic Hepatitis B Virus Carriers: A Self Control Before-after Trial

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