Efficacy and safety of acupuncture as adjuvant treatment on sepsis related gastrointestinal dysfunction: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

FAN Ziyang ¹ , LIAN Jinyu ¹ , ZHENG Yaman ¹ , ZHANG Jingyu ¹ , ZHANG Ying ² , ZHANG Zhen ² , LI Ningcen ¹ ,  XIE Keliang ^2,3 ,  CHEN Bo ^4,5,6

1. Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China;
2. Deportment of Critical Care Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, P. R. China;
3. Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin 300052, P. R. China;
4. School of Acupuncture and Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China;
5. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, P. R. China;
6. Binhai New Area Hospital of TCM, Fourth Teaching Hospital of Tianjin University of TCM, Tianjin 300451, P. R. China;

Corresponding author：

XIE Keliang, Email: xiekeliang2009@hotmail.com; CHEN Bo, Email: tjutcmchenbo@163.com

Keywords：

Acupuncture; Sepsis; Gastrointestinal dysfunction; Meta-analysis; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.202407097

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Objective To systematically review the efficacy and safety of acupuncture as adjuvant treatment on sepsis related gastrointestinal dysfunction. Methods The PubMed, Web of Science, Cochrane Library, WanFang Data, CNKI, VIP and SinoMed databases were electronically searched to collect randomized controlled trials (RCTs) related to the objectives from inception to July, 2024. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was then performed by using RevMan 5.3 software. Results A total of 20 RCTs involving 1 384 patients were included. The results of meta-analysis showed that the bowel sound frequency per minute on the 7^th day (MD=0.82, 95%CI 0.57 to 1.07, P<0.01), the effective rate of improvement in sepsis-related gastrointestinal dysfunction on the 7^th day (RR=1.38, 95%CI 1.25 to 1.54, P<0.01), intra-abdominal pressure at 7^th day (MD=−1.52, 95%CI −2.21 to −0.83, P<0.01), gastric residential volume on the 7^th day (MD=−14.94, 95%CI −24.72 to −5.16, P<0.01), APACHE-Ⅱ score at 7^th day (MD=−2.40, 95%CI −3.56 to −1.24, P<0.01), concentrations of procalcitonin on the 7^th day (MD=−1.82, 95%CI −2.68 to −0.97, P<0.01) in the acupuncture group were all superior to the conventional treatment group. However, there was no significant difference between the two groups concerning the 28-day mortality. Conclusion Current evidence shows that acupuncture adjuvant treatment can promote the recovery of bowel sounds, reduce intra-abdominal pressure, and decrease gastric residual volume in patients with sepsis and gastrointestinal dysfunction, with good safety. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.

Citation： FAN Ziyang, LIAN Jinyu, ZHENG Yaman, ZHANG Jingyu, ZHANG Ying, ZHANG Zhen, LI Ningcen, XIE Keliang, CHEN Bo. Efficacy and safety of acupuncture as adjuvant treatment on sepsis related gastrointestinal dysfunction: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2025, 25(5): 532-537. doi: 10.7507/1672-2531.202407097 Copy

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Chinese Journal of Evidence-Based Medicine

Efficacy and safety of acupuncture as adjuvant treatment on sepsis related gastrointestinal dysfunction: a meta-analysis

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