Objective To compare the efficacy of different concentrations of saline irrigation in treatment of chronic rhinosinusitis by network meta-analysis. Methods The CNKI, WanFang Data, CBM, VIP, Embase, PubMed and Cochrane Library databases were electronically searched to collect randomized controlled trials on different concentrations of saline irrigation in treatment of chronic rhinosinusitis from inception to March 1, 2024. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. The network meta-analysis was performed by using RevMan 5.4 and Stata 17.0 software. Results In total, 935 patients were enrolled in 15 study. The results of network meta-analysis showed that visual analogue scale sore, nasal mucosal ciliary transport rate and Lund-Kennedy sore of hypertonic saline irrigation group were superior to isotonic saline irrigation group. 2.5% hypertonic saline irrigation had best efficacy in terms of visual analogue scale sore, while 3% hypertonic saline irrigation had best efficacy in terms of mucosal ciliary transport rate and 3.5% hypertonic saline irrigation had best efficacy in terms of Lund-Kennedy sore. Conclusion Current evidence indicates that hypertonic saline irrigation has more advantages in terms of clinical efficacy rate, visual analogue scale sore, nasal mucosal ciliary transport rate and Lund-Kennedy sore, while 2.5% hypertonic saline irrigation has more advantages in terms of balancing efficacy and acceptability. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.
Citation：
OU Liangjie, WU Zhongrui, ZHANG Chenchang, ZHANG Kaidi, ZHANG Jingxuan, GE Yonggui, CHEN Wanqiang. Efficacy of nasal irrigation with different concentrations of saline in treatment of chronic rhinosinusitis: a network meta-analysis. Chinese Journal of Evidence-Based Medicine, 2025, 25(8): 902-908. doi: 10.7507/1672-2531.202412197
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
| 1. |
|
| 2. |
|
| 3. |
|
| 4. |
|
| 5. |
|
| 6. |
|
| 7. |
Eveloff JL, Warnock DG. Activation of ion transport systems during cell volume regulation. Am J Physiol, 1987, 252(1 Pt 2): F1-F10.
|
| 8. |
Lansley AB, Sanderson MJ, Dirksen ER. Control of the beat cycle of respiratory tract cilia by Ca2+ and cAMP. Am J Physiol, 1992, 263(2 Pt 1): L232-L242.
|
| 9. |
|
| 10. |
|
| 11. |
|
| 12. |
|
| 13. |
|
| 14. |
|
| 15. |
|
| 16. |
|
| 17. |
|
| 18. |
|
| 19. |
|
| 20. |
|
| 21. |
|
| 22. |
|
| 23. |
|
| 24. |
|
| 25. |
|
| 26. |
|
| 27. |
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg, 2015, 152(2 Suppl): S1-S39.
|
| 28. |
|
| 29. |
|
| 30. |
|
| 31. |
|
| 32. |
|
| 33. |
|
| 34. |
|
| 35. |
|
| 36. |
|
| 37. |
|
- 1.
- 2.
- 3.
- 4.
- 5.
- 6.
- 7. Eveloff JL, Warnock DG. Activation of ion transport systems during cell volume regulation. Am J Physiol, 1987, 252(1 Pt 2): F1-F10.
- 8. Lansley AB, Sanderson MJ, Dirksen ER. Control of the beat cycle of respiratory tract cilia by Ca2+ and cAMP. Am J Physiol, 1992, 263(2 Pt 1): L232-L242.
- 9.
- 10.
- 11.
- 12.
- 13.
- 14.
- 15.
- 16.
- 17.
- 18.
- 19.
- 20.
- 21.
- 22.
- 23.
- 24.
- 25.
- 26.
- 27. Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg, 2015, 152(2 Suppl): S1-S39.
- 28.
- 29.
- 30.
- 31.
- 32.
- 33.
- 34.
- 35.
- 36.
- 37.
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