【摘要】 目的 探讨甲氨蝶呤(MTX)联合米非司酮治疗早期异位妊娠(EP)的临床效果。 方法 收集2006年2月-2010年2月收治的早期未破裂型EP患者126例，随机分为MTX联合米非司酮组62例，单独应用MTX组64例， MTX治疗采用小剂量分次肌肉注射给药进行。 结果 126例患者中，MTX联合米非司酮组和单独应用MTX治疗组的成功率为分别为88%和65%，两组差异有统计学意义(P lt;0.05)。 结论 MTX小剂量分次给药联合米非司酮治疗早期未破裂型EP效果优于MTX的单独使用。
【Abstract】 Objective To observe the therapeutic effect of methotrexate (MTX) combined with mifepristone on early ectopic pregnancy. Methods A total of 126 patients with early ectopic pregnancy diagnosed from February 2006 to Febrary 2010 were randomly divided into two groups. In 126 patients, 62 treated with MTX combined with mifepristone were in the treatment group,and 64 treated independently with MTX were in the control group. MTX was administrated at a low dose in several times. Results In 126 patients,the success ratio of the treatment was 88% in treatment group groups and 65% in the control group; the difference between the two groups was significant (P lt;0.05). Conclusion Low-dose MTX in separate times combined with mifepriston is effective on the early ectopic pregnancy, and the therapeutic effect of the combined administration of MTX and mifepriston is better than that of the single administration with MTX.
Citation：
ZHOU Ping,WANG Tao. Therapeutic Effect of Methotrexate Combined Mifepristone on Early Ectopic Pregnancy. West China Medical Journal, 2010, 25(12): 2231-2233. doi:
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- 1. Condous G. Ectopic pregnancy: challenging accepted management strategies[J]. Aust N Z J Obstet Gynaecol, 2009, 49(4): 346-351.
- 2. 蒋凤艳, 龙凤宜. 氨甲喋呤联合米非司酮治疗异位妊娠疗效观察[J]. 广西医科大学学报, 2001, 18(3): 349-351.
- 3. 李志凌, 左绪磊, 陈涤瑕. 氨甲喋呤单次肌肉注射治疗异位妊娠适应证和检测指标的研究[J]. 实用妇产科杂志, 1999, 15(6): 305.
- 4. Stovall TG, Ling FW. Single close methotexate: an expancled clinical trial[J]. Am J Obstet Gynecol, 1993, 168(6): 1759.
- 5. 乐杰. 妇产科学 [M] . 6版. 北京: 人民卫生出版社, 2004: 111-113.
- 6. Raine-Fenning N, Hopkisson J. Management of ectopic pregnancy: a clinical approach [J] . Obstet Gynaecol Repro Med, 2009, 19(1): 19-25.
- 7. 赵辉, 杨保军, 冯力民. 宫腔镜下输卵管注射甲氨蝶呤与口服米非司酮联用在输卵管妊娠保守治疗中的应用[J]. 中国医学科学院学报, 2010, 32(3): 315-319.
- 8. Amso NN, Stabinsky SA, McFaul P, et al. Uterine thermal balloon therapy for the treatment of menorrhagia: the first 300 patients from amul-ticentre study[J]. Br J Obstet Gynaeco, 1998, 105(5): 517.
- 9. Branhar K, Coutifaris C, Esposito M. The harmacology of methotrexate[J]. Exper Opin Pharmacother, 2001, 2(3): 409-417.
