目的：替扎尼定是具有解痉作用的α２肾上腺能受体激动剂，并具有一定的胃肠道保护作用，适用于单一治疗或与非甾体消炎药（NSAIDs）联合治疗急性痉挛性疼痛。通过替扎尼定和非甾体类抗炎药物的联合应用，临床观察和评估联合用药能否增强疗效和增加安全性。方法：急性痉挛性疼痛70例，随机分为两组，一组服用替扎尼定2mg,bid+双氯芬酸50 mg,bid，一组服用双氯芬酸50 mg,bid+安慰剂2mg,bid。观察药物疗效和不良反应。结果：联用组的总有效率为70％，胃肠道不良反应发生率为12%,中枢神经系统不良反应发生率为18％；单用组的总有效率为56％，胃肠道不良反应发生率为32％，中枢神经系统不良反应发生率为10％。结论：替扎尼定和非甾体类药物联用具有更好的疗效以及更高的药物耐受性。
Citation：
FENG Ganjun,LIU Hao,ZHAO Xianfeng,et al.. Treatment of Acute Painful Muscle Spasms with Tizanidine Plus Diclofenac:A Clinical Analysis. West China Medical Journal, 2008, 23(1): 23-24. doi:
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- 2. Roland M.Back pain-An unresolved problem[J].Talkback,1983,4:4.
- 3. Kelsey JK,Cunningham L.Epidemiologic aspects of disability from rheumatic disease.In:Lawrence RC,Shulman LE,eds.Epidemiology of theRheumatic Disease.Vol.42.NewYork:Gower;1984:302-311.
- 4. Ehsanullah RSB,Page MC,Tildesley G,Wood JR.Prevention of gastroduoenal damageinduced by no-steroidal anti-inflammatory drugs:Controllede trial of ranitidine[J].BMJ,1988,297:1017-1021.
- 5. Bijlsma Jwj.Treatment of endoscopy-negative NSAID-induced upper gastrointestinal sympotoms with cimetidine:An international multicentre collaborative study[J].AZiment Pharmacol Tker,1988,2:75-83.
- 6. Davies J,Johnstone SF.Br J Pharmacol 1983,82∶409－21.
- 7. Watanabe K,Watanabe H,Maeda-Hagiwara M,Kanaoka R.Influence of a muscle relaxant,tizanidine,on gastric acid secretion and ulcers in the rat[J].Folia Pharmacol(Japan),1983,82:237-245.
- 8. McCarthy RJ,Kroni JS,Lubenow TR,et al.Effect of intrathecal tizanidine on antinociception and blood pressure in the rat[J].Pain,1990,40:333-338.
- 9. Rameyama T,Nabeshima T,Yamada S.Hypothermic and anti-inflammatory effects of tizanidine[J].Oyo Yakuri(Pharmacometrics),1986,30:867-871.
- 10. 龚耀成，梁裕,等.替扎尼定与双氯芬酸治疗急性痉挛性肌痛的比较[J].新药与临床，1997,16(5):283-285.
