Objective To discuss the pathogenesis,clinical manifestations,diagnoses and preventive methods on subsequent Wernicke encephalopathy cases of old gastric cancer patients during perioperation.
Methods Collected the data of 237 old gastric cancer patients in perioperation from October 1990 to December 2009 hospitalized in the Department of General Surgery,Lanzhou General Hospital Attached to Military Region,PLA.And then retrospectively analysed 7 patents of them who complicated with Wernicke encephalopathy to summarize the clinical manifestation, accessory examination,diagnosis,prevention, and therapy of the Wernicke encephalopathy,and associated factors with its incidence.
Results The clinical manifestations of 7 patients included nystagmus (7 cases),ataxia(4 cases),brain disorder(6 cases).Auxiliary examination:4 cases with anemia,7 cases with unusual blood biochemical examination, 5 cases with urinary ketone bodies positive,2 cases with decreasing blood vitamin B1,1 case with unusual skull MRI examination.Five patients were diagnosed before treatment and 2 case were diagnosed by experimental treatment.Finally,4 patents were cured,1 case obviously improved,1 case improved, and 1 case died.And The patients complicated with preoperative hypoproteinemia or pyloric obstruction and postoperative fistula of intestine or gastroplegia syndrome had statistical higher incidence rates of the Wernicke encephalopathy than those without these complications (P<0.05).
Conclusions The clinical manifestation of the Wernicke encephalopathy have no specificity, it is hard to diagnose,so clinicians should pay attention to it,and combine different ways to diagnose.Improving or preventing complications during perioperative period,and supplementing enough vitamin B are important preventive and therapeutic measures.
Citation:
WANG Yun,YANG Wenju. Analysis on Seven Cases Subsequent Wernicke Encephalopathy During Perioperation in Elderly Patients with Gastric Caner. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(1): 77-81. doi:
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王庆德, 殷跃文, 李振霞, 等. Wernicke 脑病六例临床分析 [J]. 中国厂矿医学, 2000, 13(5): 343-344.
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陈彦凡, 陈少贤, 潘优津. 慢性阻塞性肺疾病并发Wernicke脑病 [J]. 实用医学杂志, 2000, 16(6): 487-488.
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钟春玖, 费国强, 金莉蓉. 颅脑MRI 检查在非乙醇中毒性韦尼克脑病诊断中的价值 [J]. 临床神经病学杂志, 2005,18(2): 100-102.
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邓晓清, 郑金瓯. Wernicke 脑病四例的磁共振成像特征 [J].中华神经科杂志, 2006, 39(10): 718-719.
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钟春玖, 陈财栋, 费国强, 等. 急性双侧旁正中丘脑损害的诊断与MRI 特征 [J]. 中国临床医学, 2005, 12(2): 187-191.
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张浩如, 陈蕾. 妊娠剧吐并发Wernicke 脑病2 例分析 [J].潍坊医学院学报, 2000, 22(4): 315-316.
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Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition [J]. Eur J Oncol Nurs, 2005, 9 Suppl 2: S51-S63.
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Fischer J, Müller A, Pohl C, et al. Threatening thiamine deficiency in severe hyperemesis gravidarum [J]. Schweiz Med Wochenschr, 1993, 123(10): 428-431.
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马水清, 邓姗, 范光升. 妊娠剧吐并发Wernicke 脑病三例报告 [J]. 中华妇产科杂志, 2000, 35(12): 744-745.
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鲁晓燕, 张挽时, 李立伟, 等. 胃瘘并发Wernicke 脑病一例 [J]. 中华放射学杂志, 1999, 33(11): 774.
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蒋雨平, 蒋雯, 杨德泰, 等. 临床神经病学 [M]. 上海: 上海医科大学出版社, 1999: 401-402.
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- 1. 廖忠银, 张安兴, 刘爱武. 慢性酒精中毒性神经病38 例临床分析 [J]. 中华现代临床医学杂志, 2005, 3(20): 2129-2130.
- 2. 朱立, 应远峰. 非酒精性Wernicke 脑病16 例临床分析 [J].现代中西医结合杂志, 2006, 15(7): 926-927.
- 3. 王秀娟, 徐建英. 妊娠剧吐致Wernicke 脑病4 例分析 [J].中国实用妇科与产科杂志, 1999, 15(7): 423.
- 4. 洪冰, 丁美萍. 7 例Wernicke 脑病患者临床分析 [J]. 浙江医学, 2003, 25(5): 302- 302, 306.
- 5. 董为伟主编. 实用临床神经病学 [M]. 北京. 中国医药科技出版社, 2001: 532-533;.
- 6. Bergin PS, Harvey P. Wernicke’s encephalopathy and central pontine myelinolysis associated with hyperemesis gravidarum[J]. BMJ, 1992, 305(6852): 517-518.
- 7. Rotman P, Hassin D, Mouallem M, et al. Wernicke’s encephalopathy in hyper mesis gravidarm: association with abnormal liver function [J]. Isr J Med Sci, 1994, 30(3): 225-228.
- 8. 陈敏章主编. 中华内科学 [M]. 北京: 人民卫生出版社,1999: 3992-3993.
- 9. 黄克维, 吴丽娟主编. 临床神经病理学 [M]. 北京: 人民军医出版社, 1999: 190-191.
- 10. 李大年主编. 现代神经内科学 [M]. 济南: 山东科学技术出版社, 2002: 767-768.
- 11. 黄一镗主编. 神经系统综合病征 [M]. 福州: 福建科学技术出版社, 1981: 68-69.
- 12. 孙金豹, 纪江海. 妊娠剧吐并发Wernick 脑病1 例 [J]. 中华中西医杂志, 2003, 4(9): 70.
- 13. 方青流, 芮红, 宋汉明, 等. 急性胰腺炎并发Wernicke 脑病一例 [J]. 中华消化杂志, 2000, 20(6): 377.
- 14. Suzuki K, Takiguchi Y, Suzuki S, et al. Magnetic resonance images in rhombencephalitis due to listeria monocytogenes mimicking Wernicke encephalopathy [J]. Intern Med, 2008,47(8): 817-818.
- 15. 陈隆典, 张晓琦. 胰性脑病与韦尼克脑病 [J]. 中华内科杂志, 2002, 41(2): 94-97.
- 16. 陈建利, 王波, 江森, 等. 娠剧吐并发Wernicke 脑病 [J].国外医学妇产科学分册, 1998, 25(1): 10-13.[ 17] 陈芷若. Wernicke 脑病 [J]. 国外医学神经病学神经外科分中国普外基础与临床杂志2012 年1 月第19 卷第1 期 Chin J Bases Clin General Surg, Vol. 19, No. 1, Jan. 2012 ? 81 ?册, 1984, 11(6): 300.
- 17. Opdenakker G, Gelin G, De Surgeloose D, et al. Wernicke encephalopathy: MR findings in two patients [J]. Eur Radiol,1999, 9(8): 1620-1624.
- 18. Rugilo CA, Uribe Roca MC, Zurru MC, et al. Proton MR spectroscopy in Wernicke encephalopathy [J]. AJNR Am J Neuroradiol,2003, 24(5): 952-955.
- 19. 王庆德, 殷跃文, 李振霞, 等. Wernicke 脑病六例临床分析 [J]. 中国厂矿医学, 2000, 13(5): 343-344.
- 20. 陈彦凡, 陈少贤, 潘优津. 慢性阻塞性肺疾病并发Wernicke脑病 [J]. 实用医学杂志, 2000, 16(6): 487-488.
- 21. 王发明, 王坚. Wernicke 脑病综合征10 例临床分析 [J]. 中国临床神经科学, 2006, 14(4): 410-411.
- 22. 钟春玖, 费国强, 金莉蓉. 颅脑MRI 检查在非乙醇中毒性韦尼克脑病诊断中的价值 [J]. 临床神经病学杂志, 2005,18(2): 100-102.
- 23. 邓晓清, 郑金瓯. Wernicke 脑病四例的磁共振成像特征 [J].中华神经科杂志, 2006, 39(10): 718-719.
- 24. 钟春玖, 陈财栋, 费国强, 等. 急性双侧旁正中丘脑损害的诊断与MRI 特征 [J]. 中国临床医学, 2005, 12(2): 187-191.
- 25. 张浩如, 陈蕾. 妊娠剧吐并发Wernicke 脑病2 例分析 [J].潍坊医学院学报, 2000, 22(4): 315-316.
- 26. Van Cutsem E, Arends J. The causes and consequences of cancer-associated malnutrition [J]. Eur J Oncol Nurs, 2005, 9 Suppl 2: S51-S63.
- 27. Fischer J, Müller A, Pohl C, et al. Threatening thiamine deficiency in severe hyperemesis gravidarum [J]. Schweiz Med Wochenschr, 1993, 123(10): 428-431.
- 28. 马水清, 邓姗, 范光升. 妊娠剧吐并发Wernicke 脑病三例报告 [J]. 中华妇产科杂志, 2000, 35(12): 744-745.
- 29. 毛悦时, 汪昕. Wernicke 脑病研究新进展 [J]. 国外医学神经病学神经外科学分册, 1997, 24(5): 258-260.
- 30. 鲁晓燕, 张挽时, 李立伟, 等. 胃瘘并发Wernicke 脑病一例 [J]. 中华放射学杂志, 1999, 33(11): 774.
- 31. 蒋雨平, 蒋雯, 杨德泰, 等. 临床神经病学 [M]. 上海: 上海医科大学出版社, 1999: 401-402.