ObjectiveTo explore the application of extracorporeal venovenous bypass in orthotopic liver transplantation in pigs and to compare hemodynamic changes during operation of two different bypass ways. MethodsTwentyfive porcine orthotopic liver transplantations were performed and extracorporeal venovenous bypass was established during anhepatic phase through a catheter in portal vein (group A,n=16) or in splenic vein (group B,n=9).Hemodynamic changes were monitored continuously.ResultsFourteen recipients survived two days after operation (14/16) in group A while all survived in group B (9/9).Transient hemodynamic disturbance (MAP and CVP decreased,and HR increased) was monitored at both the beginning and the end of anhepatic stage in group A,while these parameters kept stable in group B (P＜0.05).ConclusionApplying venovenous bypass may stabilize recipients’ hemodynamics in porcines orthotopic liver transplantation,and splenic vein draining way has more advantages than portal vein.
Citation：
HE Chunshui,HE Yanzheng,TIAN Gendong,ZHONG Wu. Extracorporeal Venous Bypass in Porcine Orthotopic Liver Transplantation: A Comparative Study. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(2): 125-127. doi:
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- 1. Paulsen AW, Whitten CW, Ramsay MA, et al. Considerations for anesthetic management during venovenous bypass in adult hepatic transplantation [Ｊ]. Anesth Analg,1989; 68(4)∶489.
- 2. Kuo PC,Alfrey EJ,Garcia G, et al. Orthotopic liver transplantation with selective use of venovenous bypass [Ｊ].Am J Surg, 1995; 170(6)∶671.
- 3. 黄洁夫，杨清水，陈规划，等．体外静脉转流下的猪原位肝移植术血流动力学及血生化的改变 [Ｊ].中山医科大学学报，1994； 15(3)∶177.
- 4. de la Morena G, Acosta F, Villegas M, et al. Ventricular function during liver reperfusion in hepatic transplantation [Ｊ].Transplantation,1994; 58(3)∶306.
- 5. Lo CM, Fan ST, Liu CL, et al. Adulttoadult living donor liver transplantation using extended right lobe grafts [Ｊ]. Ann Surg,1997; 226(3)∶261.
