Research on the Plasma Endothelin and Gastric Mucusal Pathology in Obstructive Jaundice_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Dongwei ¹

Department of Surgery, Post and Communication Hospital of Heilongjiang Province, Harbin 150001，China;

Corresponding author：

Keywords：

Obstructive jaundiceEndothelinGastric mucosal damage

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Objective To investigate the correlation between the plasma endothelin (ET) and gastric mucosal pathology.MethodsIn this experiment,seven dogs who experienced common bileduct ligation were in experiment group, the other three dogs who underwent shamoperation were control group. By using specific radio immunological method, the plasma ET levels were determined in dogs before and after 1,4,7 d. The total bilirubin levels were determined before and after 1,4,7 d after operation by using carbazotic acid method.The gastric mucosa,7 d after operation, was cut into slices and was examined under the electron microscope and the light microscope.Results In the experiment group,the levels of ET and total bilirubin rose continually and were higher than those in control group. Vascular congestion and oedema were seen in gastric mucosa of common bileduct ligated dogs. Under the electron microscope, we could see the dilated blood capillary and sludging of blood,the intenstitial mucusa cells oedema. Conclusion The increase of plasma ET might lead to impairment of mucosal microcirculation,which might be one of the pathogens that could induce the gastric mucosal damages in common bileduct ligated dogs.

Citation： ZHANG Dongwei,WANG Guoqing,PIAO Daxun. Research on the Plasma Endothelin and Gastric Mucusal Pathology in Obstructive Jaundice. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(5): 463-465. doi: Copy

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1. 孟宪民，李哲浩，魏国玉.　梗阻性黄疸并发急性胃病变的机理　 [Ｊ].　普外临床， 1991； 6（1）∶38.
2. Wallance JL，Cirino G，De Nucci G, et al.Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach　 [Ｊ].Am J physiol， 1989;　256(4 Pt 1)∶G661.
3. AlexanderWilliams J,Wolverson RL.Pathogenesis and pathophysiology of gastric ulcer　 [Ｊ].Clin Gastroenterol, 1984;　13(2)∶601.
4. Deitch EA, Sittig K, Li M, et al. Obstructive jaundice promotes bacterial translocation from the gut　 [Ｊ]. Am J Surg, 1990;　159(1)∶79.
5. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstricitor peptide produced by vascular endothelial cells　 [Ｊ]. Nature， 1988;　332（6163）∶411.
6. 谢鹏雁，黄莚庭. 胃十二指肠溃疡病基础研究的新进展　 [Ｊ]. 中国普外基础与临床杂志， 1998； 15（3）∶165.
7. 黎介寿. 应激性溃疡　 [Ｊ]. 中国实用外科杂志， 1998； 18（1）∶45.
8. 孙绍金，黄裕新，许财绂. 内皮素对胃肠损伤作用机制的研究进展　 [Ｊ].新消化病学杂志， 1996；　4（4）∶224.
9. Battal NM， Hata Y， Ito O，et al. Reduction of burninduced gastric mucosal injury by an endothelin receptor antagonist in rats　 [Ｊ].Burns, 1997;　23（4）∶295.
10. Michida T， Kawano S， Masuda E，et al. Role of endothelin 1 in hemorrhagic shockinduced gastric mucosal injury in rats　 [Ｊ].Gastroenterology, 1994；　106(4)∶988.
11. Fukumura D, Jurose I, Miuras, et al.Role of plateletactivating factor (RAF) on endothelin induced microvascular disturbance in rat stomach　 [Ｊ]. Intestinal Disorder, 1991;　100(5)∶211.
12. Simonson MS， Dunn MJ. Endothelins: a family of regulatory peptides state of the art lecture　 [Ｊ]. Hypertension， 1991;　17(7)∶856.
13. 冯祖亮，王平，冯新为. 梗阻性黄疸患者的内毒素血症及其对机体的影响　 [Ｊ].中国普通外科杂志， 1995；　10（2）∶76.
14. Kanse SM , Takahashi K,Lam HC, et al.Cytokine stimulated endothelin release from endothelial cells　 [Ｊ].Life Sci, 1991；　48(14)∶1379.
15. 钟守先. 梗阻性黄疸围手术期处理　 [Ｊ]. 临床外科杂志， 1996；　4（1）∶3.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research on the Plasma Endothelin and Gastric Mucusal Pathology in Obstructive Jaundice

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