【Abstract】Objective To investigate the protective effect of improving the pancreatic ischemia and calcium channel blockers on preventing the progression of acute pancreatitis. Methods Twenty-four patients with mild acute pancreatitis were randomly divided into two groups： control group and treated group. Within the first 72 hours from the onset of AP, routine conservative managements were performed in control group, improving the pancreatic ischemia and preventing Ca2+ overload were performed in treated group for two weeks. The hemorrheological parameters were measured at 1,4,7,14 days after adimission, simultanously, serum TNFα, IL-1β, C-reactive protein and plasma TXB2, 6-keto-PGF1α levels were determined with ELISA methods. Results The hemorrheological changes were improved in treated group, serum TNFα, IL-1β, C-reactive protein and plasma TXB2, 6-keto-PGF1α levels were significantly decreased each time point in treated group as compared with control group. Conclusion Improving the pancreatic ischemia and calcium channel blockers have protective effect through reducing the generation of cytokines and inflammatory mediators on preventing the progression of acute pancreatitis.
Citation：
PU Qingfan,YAN Lnan,SUN Suikang,et al.. EFFECT OF IMPROVING THE PANCREATIC ISCHEMIA AND CALCIUM CHANNEL BLOCKERS ON PREVENTING THE PROGRESSION OF ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(6): 384-386. doi:
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蒲青凡，严律南，张川蓉等. 阻止急性胰腺炎由轻型向重症转化的非手术治疗172例报告 〔Ｊ〕. 中华普通外科杂志， 2000； 15（5）∶289.
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- 1. 蒲青凡，严律南，沈骥等. 胰腺腺泡细胞钙超负荷在诱发大鼠由水肿性向坏死性胰腺炎转变中的作用 〔Ｊ〕. 中华医学杂志， 1999； 79（2）∶143.
- 2. Karne S, Gorelick FS. Etiopthogenesis of acute pancreatitis 〔Ｊ〕. Surg Clin North Am, 1999; 79(4)∶699.
- 3. Denham W, Norman J. The potential role of therapeutic cytokine manipulation in acute pancreatitis 〔Ｊ〕. Surg Clin North Am, 1999； 79(4)∶767.
- 4. Bradley EL III. A clinically based classification system for acute pancreatitis: summary of the international symposium on acute pancreatitis Atlanta 1992 〔Ｊ〕. Arch Surg, 1993; 128(3)∶586.
- 5. Beger HG, Isenmann R. Surgical management of necrotizing pancreatitis 〔Ｊ〕. Surg Clin North Am, 1999; 79(4)∶783.
- 6. Steinberg WM, Tenner S. Acute pancreatitis 〔Ｊ〕. N Engl J Med, 1994; 330(6)∶1198.
- 7. Yan LN, Liu XB, Tan JS, et al. Effect of hemorrheological changes in the transition of oedematous pancreatitis to necrosis 〔Ｊ〕. Asian J Surg, 1995; 18(2)∶106.
- 8. Klar E, Foitzik T, Buhr H, et al. Isovolemic hemodilution with Dextran 60 as treatment of pancreatic ischemia in acute pancreatitis 〔Ｊ〕. Ann Surg, 1993; 217(4)∶369.
- 9. Mithofer K, Fernandezdel Castillo C, Frick TW, et al. Acute hypercalcemia cause acute pancreatitis and ectopic trypsinogen activation in the rat 〔Ｊ〕. Gastroenterology, 1995; 109(1)∶239.
- 10. 蒲青凡，严律南，张川蓉等. 阻止急性胰腺炎由轻型向重症转化的非手术治疗172例报告 〔Ｊ〕. 中华普通外科杂志， 2000； 15（5）∶289.
