To find the relation between the damage of gastric remnant mucosal barrier and the precancerous lesion of gastric remnant mucosa, in the process of the canine gastric remnant precarcinogenesis induced by N-methyN’-nitro-N-nitrosoguanidine (MNNG), we performed regularly the esophagogastroscopy and the mucosal biopsy.At the same time, we also measured gastric transmucosal potential difference and intracellular DNA content of remnant mucosa.We found that the more severe the damage of gastric remnant mucosal barrier was , the greater the malignant capacity of gastric remnant mucosal was.Our study suggests that the damage of gastric remnant mucosal barrier plays an important role in the gastric remnant mucosal precarcinogenesis.
Citation：
Tang Lijun,Tian Fuzhou,Ma Xiaolin,et al.. EXPERIMENTAL STUDY ON THE RELATION BETWEEN THE DAMAGE OF GASTRIC REMNANT MUCOSAL BARRIER AND THE PRECANCEROUS LESION OF GASTRIC REMNANT MUCOSA AFTER SUBTOTAL GASTRECTOMY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(1): 7-10. doi:
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- 1. Takeuchi. Clinical study on gastric mucosal blood flow and potential difference. Gastroenterological Endoscope, 1987; 29(5)∶845.
- 2. 全国胃癌防治研究协作组病理组. 胃及十二指肠粘膜活检病理. 第1版. 沈阳： 辽宁人民出版社， 1991∶134～135.
- 3. Morris CP, Hoei L, Yelson K, et al. Correlation between changes in indicators of gastric mucosal barrier integrity at time of exposure to “barrier breaker” and extent of hemorrhagic erosions one hour later. Dig Dis Sci, 1984; 29(1)∶6.
- 4. Goddard PJ, Lenard DM. In vitro recovery of canine gastric mucosal surface hydrophobicity and potential difference after aspirin damage. Dig Dis Sci, 1995; 40(6)∶1357.
- 5. Sorbye H, Pieol HY, Scot LE, et al. Gastric carcinogenesis in rats given hypertonic salt at different times before a single dose of MNNG. J Cancer Res Clin Oncol, 1994; 120(120)∶159.
- 6. Hiraki Y. Experimental study of the effect of bile juice on the remnant gastric cancer development. Hippon Geka Gakkai Zasshi, 1991; 92(6)∶645.
- 7. 汤礼军， 晏才杰， 麻晓林等. MNNG诱发犬残胃粘膜癌前病变组织中MG7Ag表达的动态定量研究. 胃肠病学和肝病学杂志， 1996； 5(1)∶32.
- 8. Imai T, Moit L, Soue H,et al. Reduction of cell proliferative activities of gastric stump adenomatous hyperplasias after bile reflux diversion in rats. Carcinogenesis, 1993; 14(23)∶1765.
- 9. Tanigawa N, Masuda Y, Shimo T, et al. Thymidine uptake in vitro as a prognostic indicator for primary gastric cancer. Cancer, 1993; 72(10)∶2883.
- 10. Fisher SG, Davis F, Nelson R, et al. A cohort study of stomach cancer risk in men after gastric surgery for benign disease. J Natl Cancer Inst, 1993; 85(16)∶1303.
