CHANGES OF GLYCOCHOLIC ACID AND PANCREATIC GLUCAGON IN PORTAL AND PERIPHERAL VENOUS BLOOD OF RATS WITH EXPERIMENTAL CIRRHOTIC PORTAL HYPERTENSION AND AFTER PORTALAZYGOUS DEVASCULARIZATIOIN_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Yuan Hui ¹ , Sun Gefei. ²

Department of General Surgery, Guangzhou Second People’s Hospital,Guangzhou 510150;

Corresponding author：

Keywords：

Rat; Liver cirrhosis; Hypertension portal; Glycochotic acid; Pancreatic glucagon; Porta-azygous devascularization

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To investigate the change of the portal venous pressure (PVP), conjugated glycocholic acid (CGA) and pancreatic glucagon (PG) concentration in rats peripheral and portal venous blood in the course of experimental liver cirrhosis induced with carbon tetrachloride and to investigate the mentioned changes after portalazygous devascularization. The authors found that in the early stage of cirrhosis the PVP and the concentration of CGA and PG in peripheral venous blood were increased markedly, CGA in portal vein was decreased and PG in portal vein was increased in early stage of liver cirrhosis.With the extent of liver cirrhosis the indexes above changed more markedly. After portalazygous devascularization the concentration of CGA in peripheral vein in the cirrhotic rats was increased but PVP, the concentration of CGA in portal vein and PG in peripheral and portal vein did not change.There was no change in nornal rats. The results suggest that the variation in CGA in peripheral vein can accurately reflect the degree of damage to liver cells, thus making the diagnosis of liver cirrhosis earlier and judging the degree and prognosis of liver cirrhosis.The concentration of PG in portal venous and peripheral vein relate to PVP in liver cirrhosis.Portalazygous devascularization can maintain PVP and PG in portal vein and do not affect liver function of the control rats but it can damage liver cell in cirrhotic rats.

Citation： Yuan Hui,Sun Gefei.. CHANGES OF GLYCOCHOLIC ACID AND PANCREATIC GLUCAGON IN PORTAL AND PERIPHERAL VENOUS BLOOD OF RATS WITH EXPERIMENTAL CIRRHOTIC PORTAL HYPERTENSION AND AFTER PORTALAZYGOUS DEVASCULARIZATIOIN. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(1): 18-20. doi: Copy

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6.	范尚廉，李振甲，陈伟英等. 空腹血清结合胆酸测定在慢性肝病中的临床价值. 中华内科杂志， 1982； 21(7)∶386.
7.	李向农，黄萃庭，王新慧等. 实验性肝硬变大鼠血中液递物质的变化及其对血液动力学的影响. 中华外科杂志， 1989； 27(8)∶489.
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10.	朱舜时，金冠球，柳振美等. 肝炎后肝硬化和肝昏迷患者糖代谢与调节糖代谢激素的观察. 中华消化杂志， 1986； 6(2)∶82.
11.	吴志勇，邝耀麟，陈治平等. 门静脉高压症门体分流术后胰岛素和胰高糖素代谢变化的研究. 中华消化杂志， 1989； 9(3)∶154.
12.	张同琳，陈志刚，张挽华等. 门静脉内胰岛素的含量对分流术后肝脏的影响. 中华外科杂志， 1987；25(2)∶712.

1. 吴孟超，杨广顺. 大鼠肝硬变模型复制的研究. 中华实验外科杂志， 1984； 1(4)∶145.
2. 袁晖，孙格非. 鼠肝硬化门脉高压形成中和门奇断流术后血胰岛素变化的研究. 江西医学院学报， 1992； 32(2)∶105.
3. Mannes GA. Increased serum bile acid in cirrhosis with normal treasaminase. Digestion, 1982; 25(3)∶217.
4. 吴玉娥，段仲壁，习杰英. 80例肝硬变患者空腹血清甘胆酸测定及分析. 陕西医学杂志， 1992； 21(5)∶271.
5. 任成山，徐纬申，胡杨滕等. 血清甘胆酸含量对肝硬变预后的意义. 中华内科杂志， 1992； 31(3)∶170.
6. 范尚廉，李振甲，陈伟英等. 空腹血清结合胆酸测定在慢性肝病中的临床价值. 中华内科杂志， 1982； 21(7)∶386.
7. 李向农，黄萃庭，王新慧等. 实验性肝硬变大鼠血中液递物质的变化及其对血液动力学的影响. 中华外科杂志， 1989； 27(8)∶489.
8. Nakamura T, Otsuki M, Tani S, et al. Pancreatic endocrine function in cirrhotic rats.Metabolism, 1988; 37(9)∶892.
9. Alwmark A, Mamlok V, Greeley GH, et al. Insulin and glucagon production in experimental cirrhosis. Ann Surg, 1987; 205(1)∶9.
10. 朱舜时，金冠球，柳振美等. 肝炎后肝硬化和肝昏迷患者糖代谢与调节糖代谢激素的观察. 中华消化杂志， 1986； 6(2)∶82.
11. 吴志勇，邝耀麟，陈治平等. 门静脉高压症门体分流术后胰岛素和胰高糖素代谢变化的研究. 中华消化杂志， 1989； 9(3)∶154.
12. 张同琳，陈志刚，张挽华等. 门静脉内胰岛素的含量对分流术后肝脏的影响. 中华外科杂志， 1987；25(2)∶712.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

CHANGES OF GLYCOCHOLIC ACID AND PANCREATIC GLUCAGON IN PORTAL AND PERIPHERAL VENOUS BLOOD OF RATS WITH EXPERIMENTAL CIRRHOTIC PORTAL HYPERTENSION AND AFTER PORTALAZYGOUS DEVASCULARIZATIOIN

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