Tostudytheexpressionofproliferatingcellnuclearantigen(PCNA)inhumangastricneoplasmanditsclinicalsignificance.TheexpressionofPCNAwassemiquantitativelyanalysedimmunohistochemically(ABC)in10gastricadenomatouspolypand94gastriccarcinomas.Results:①PCNAlabelingindex(LI)showedasignificantdifferentiationindifferentpathologicstate(P lt;0.01),②PCNALIingastriccarcinomawasindepednetofsexandage(P gt;0.05),butcorrelatedwiththegrowingmannerofthetumor,tumordifferentiation,serosalinfiltration,nodalmetastasisandclinicalstages(P lt;0.05),③ThecorrelationwasfoundbetweenPCNALIandprognosisofgastriccarcinoma(P lt;0.05).AmoderategradeofPCNAexpressiongenerallyhadabetterprognosis.Conclusions:TheseresultssuggestthatPCNALIisafairlygoodindextoindicatebiologicbehaviorandprognosisingastriccarcinoma.
Citation:
WangKang,SunXuejun,JiaZongliang,etal.. EXPRESSIONOFPROLIFERATINGCELLNUCLEARANTIGENINHUMANGASTRICNEOPLASMANDITSCLINICALSIGNIFICANCE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(4): 224-226. doi:
Copy
Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
1. |
ShouW,GregoryJH,DavidB,etal.Thep21inhibitorofcyclyindependentkinasescontrolDNAreplicationbyinteractionwithPCNA.Nature,1994;369(16)∶574.
|
2. |
DierendonckJH,WijsmanJH,KeijzerR,etal.Cellcyclerelatedstainingpatternsofantiproliferatingcellnuclearantigenmonoclonalantibodies.ComparisonwithBrdUrdlabelingandKi67staning.AmJPathol,1991;138(5)∶1165.
|
3. |
NishidaT,TanakaS,HarurmaK,etal.Histologicgradeandcellularproliferationatthedeepestinvasiveportioncorrelatewiththehighmalignancyofsubmucosalinvasivegastriccarcinoma.Oncology,1995;52(4)∶346.
|
4. |
ShirokoT,SajiS,KawaguchiY,etal.AstudyontherelationshipbetweenclinicalpathologicalfindingsofgastriccanceranditsbiologicalbehaviorsuchasDNAploidypatternandimmunohistochemicalstainingofPCNA,laminin,p53andnm23.GanToKagakuRyoho,1995;22(Suppl2)∶118.
|
5. |
MoriM,KakejiY,AdachiY,etal.Theprognosticsignificanceofproliferatingcellnuclearantigeninclinicalgastriccancer.Surgery,1993;113(6)∶683.
|
- 1. ShouW,GregoryJH,DavidB,etal.Thep21inhibitorofcyclyindependentkinasescontrolDNAreplicationbyinteractionwithPCNA.Nature,1994;369(16)∶574.
- 2. DierendonckJH,WijsmanJH,KeijzerR,etal.Cellcyclerelatedstainingpatternsofantiproliferatingcellnuclearantigenmonoclonalantibodies.ComparisonwithBrdUrdlabelingandKi67staning.AmJPathol,1991;138(5)∶1165.
- 3. NishidaT,TanakaS,HarurmaK,etal.Histologicgradeandcellularproliferationatthedeepestinvasiveportioncorrelatewiththehighmalignancyofsubmucosalinvasivegastriccarcinoma.Oncology,1995;52(4)∶346.
- 4. ShirokoT,SajiS,KawaguchiY,etal.AstudyontherelationshipbetweenclinicalpathologicalfindingsofgastriccanceranditsbiologicalbehaviorsuchasDNAploidypatternandimmunohistochemicalstainingofPCNA,laminin,p53andnm23.GanToKagakuRyoho,1995;22(Suppl2)∶118.
- 5. MoriM,KakejiY,AdachiY,etal.Theprognosticsignificanceofproliferatingcellnuclearantigeninclinicalgastriccancer.Surgery,1993;113(6)∶683.