Immunohistochemical study on 39 specimens of hepatobilibary duct stricture due to stones were performed. Collagen types Ⅲ and Ⅳ were studied by quantitative analysis. The results showed that significant increase of type Ⅲ collagen was found in the stenotic bile duct wall, the portal area and liver sinusoid with fibrosis. Abnormal increasing of type Ⅳ collagen was found in the liver sinusoid of the stenotic bile duct.
Citation：
Xia Xianming,Zhang Peiming,Liu Guangyi,et al.. IMMUNOHISTOCHEMICAL STUDY ON COLLAGENS OF HEPATOBILIARY DUCT STRICTURE DUE TO STONES WITH LIVER FIBROSIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(2): 75-77. doi:
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- 1. Kawahara, Ayumu Mukai, Yoshio Oda, et al. Left ventriculotomy of the heart: tissue repair and localization of collagen types Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ,Ⅵ and fibronectin. Virchows Archiv A Pathol Anat, 1990; 417∶229.
- 2. Schuppan D, Thomas R, Echart G, et al. Radioimmunoassay for human type Ⅵ collagen and its application to tissue and body fluids. Anal Biochem, 1985; 149∶238.
- 3. Clement B, Grimaud JA, Campion JP, et al. Cell types involved in collagen and fibronectin production in normal and fibrotic human liver. Hepatology, 1986; 6(2)∶225.
- 4. Chiharu MD, Takashi K, Kyoichi I, et al. Ultrastructural localization of type Ⅳ collagen in biliary epithelial cells of rat liver following ligation of the common bile duct. J Gastroenterol, 1987; 22(3)∶354.
- 5. 夏先明，张陪明，刘广益等. 肝胆管结石并狭窄胆管的组织构筑变化及意义.普外基础与临床， 1996； 3(3)∶133.
- 6. Weiner FR, Giambrone MA, Czaja M, et al. Itocell gene expression and collagen regulation. hepatology, 1989; 11(1)∶111.
- 7. 朱国静， 范宗滂. 肝纤维化发病机理、诊断及治疗的进展. 临床肝胆病杂志， 1993； 9(4)∶178.
- 8. Gamal A, Pierre Y, Bruno C, et al. Cellular sources of matrix proteins in experimentally induced cholestatic rat liver. J Pathol, 1991; 164∶167.
- 9. Clement B, Pierre Y, Goerges B, et al. Hepatocytes may produce laminin in fibrotic liver and in primary culture. Hepatology, 1988; 8(4)∶794.
