42 Wistar rats were divided into three groups at random, liver cirrhosis (LC), portal vein stricture (PVS) and sham operation (SO) group. The changes of barrier capability of gastric mucosa in portal hypertensive rats were observed. The results demonstrated: the splanchnic blood flow of the portal hypertensive rats increased, as compared with the normal control group (Ｐ＜0.001), but actually gastric mucosa was under the condition of ischemia. Mucosa of gastric wall glycoprotein and PGE2 of gastric mucosa decreased, as compared with the normal control (Ｐ＜0.01); and more seriously decreased in cirrhotic portal hypertensive rats, there was no significant difference about amount of the basal acid secretion (BAS) among the three groups, but the amount of H＋ backdiffusion (H＋BD) was obviously increased, as compared with the normal control group (Ｐ＜0.001). The amount of H＋BD of cirrhotic portal hypertensive rats was the highest among this three groups. The results suggest that the barrier capability of gastric mucosa with portal hypertension is lower than that of the normal control group and much lower with cirrhotic portal hypertensive rats. The portal hypertensive gastropathy is associated with the lower capability of defense of gastric mucosa. The condition of liver function contributes to the change of barrier capability of gastric mucosa.
Citation：
Zhou Dongfeng,Sun Zuoxiang,Liang Guihua,et al.. EXPERIMENTAL STUDY ON THE BARRIER CAPABILITY OF GASTRIC MUCOSA IN PORTAL HYPERTENSIVE RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(3): 135-137. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. McCormack TT, Simms J, EreBrooke I, et al. Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? Gut, 1985; 26(1)∶1226.
- 2. Quinter E, Pique JM, Bombi JA, et al.Gastric mucosal ectasias causing bleeding in cirrhosis. Gastroenterology, 1987; 93(5)∶1054.
- 3. 吴孟超，杨广顺.大鼠肝硬变模型复制的研究. 中华实验外科杂志， 1984； 1(4)∶145.
- 4. Pique JM, Leung FM, Kitahora T, et al.Gastric mucosal blood flow and acid secretion in portal hypertensive rats. Gastroenterology, 1988; 95(3)∶727.
- 5. Sarfeh IJ, Tarnawski A, Malki, A, et al.Portal hypertension and gastric mucosal injury in rats. Gastroenterology, 1983; 84(5)∶987.
- 6. Agustin A, Luis A, Colombato, et al. Sequence of morphological and hemodynamic changes of gastric microvessels in portal hypertension. Gastroenterology, 1992; 102(6)∶2066.
- 7. Lundergren O. Gastric mucosal hemodynamics. Gastroenterol Cli Biol, 1985; 9(1)∶26.
- 8. Malagelada JR, Ahiguist DA, Moore Sc. Effect in prostaglandin synthesis and metablism in ulcer disease. Dig Dis Sci, 1986; 31(10)∶20S.
- 9. Viggiano TR, Gostout CJ. Portal hypertensive intestinal vasculopathy. Am J Gastroenterol, 1992; 87(8)∶944.
