In order to study effect of endothelin (ET-1) on hepatic blood flow in rats and effect of nitric oxide (NO) and prostacyclin (PGI2) on ET-1 biological function, 20 rats were randomized into control, ET-1, ET-1 plus nitric-Larginine, ET-1 plus prostacyclin and indomethen groups. The result showed that ET-1 decreased hepatic blood flow and lasted for longer time. NO and PGI2 may antagonize the biological action of ET-1 during endotoxemia. Therefore, the endothelium-derived vascular factors may regulate hepatic blood flow.
Citation：
Liu Baohua,Wang Daike,Chen Huisun,et al.. EFFECT OF ENDOTHELIN-1 ON HEPATIC BLOOD FLOW IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(4): 193-194. doi:
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Goligorsky MS, Tsukahara H, Magazine H, et al. Termination of endothelin signaling:role of nitric oxide. J Cell Physiol, 1994; 158(5)∶485.
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- 1. Luscher TF, Oemar BS, Moulanger CM,et al. Molecular and cellular biology of endothelin and its receptor partⅡ. J Hypertension, 1993; 11(2)∶121.
- 2. 杨恒文，胡文辉，丁珍明等.大鼠脊髓腹侧鼠损伤脊髓组织血流量的变化.中华神经外科杂志， 1991； 7(2)∶87.
- 3. Kitsukawa Y, Gu ZF, Hildebrand P, et al. Gastric smooth muscle cells possess two classes of endothelin receptor but one alters contractin. Am J Physiol, 1994; 266(4 Pt 1)∶G713.
- 4. Housset C, Rockey DC, Bissell M, et al. Endothelin receptor in rat liver: lipocytes as a contractile target for endothelin1. Proc Natl Acad Sci USA, 1993; 90(10)∶9266.
- 5. Sakamoto M, Uero T, Kin M, et al. Ito cell contraction response to endothelin1 and substance P. Hepatology Baltimore, 1993; 18(4)∶978.
- 6. 刘宝华，陈惠孙.内毒素与PGI2及NO的相互作用.国外医学生理病理学与临床分册，1996； 16(1)∶46.
- 7. Goligorsky MS, Tsukahara H, Magazine H, et al. Termination of endothelin signaling:role of nitric oxide. J Cell Physiol, 1994; 158(5)∶485.
