To verify the role of mAbCD28 in allograft transplantation. The biological action of mAbCD28 had been tested in mixed-lymphocyte-reaction and parathyroid gland allotranplantation in rats. Results: mAbCD28 could significantly suppress the proliferation of T cells in vitro and prolong the survival time of allograft in vivo. The results showed that mAbCD28 could block the costimulatory signals transmitted by CD28 molecules, and played an immunosuppressive role in parathyroid gland transplantation in rats.
Citation：
Xiao Yi,Zhu Yu,Wang Shuhui.. mAbCD28 PLAYS AN IMMUNOSUPPRESSIVE ROLE IN ALLOGRAFT TRANSPLANTATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 260-262. doi:
Copy
Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol, 1993; 11∶191.
|
| 2. |
陈力真，王树蕙，张云等.人化SCID鼠的建立及其对脊髓灰质炎病毒的免疫应答.中华微生物学和免疫学杂志，1995； 15∶82.
|
| 3. |
Martin PJ, Ledbetter JA, Morishita Y, et al. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol, 1986; 136∶3282.
|
| 4. |
Damle NK, Doyle LV, Grosmaire LS, et al. Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes. J Immunol, 1988; 140∶1753.
|
| 5. |
Lin H, Bolling SF, Linsley PS, et al. Longterm acceptance of major histocompatbility complex mismatched cardiac allografts induced by CTLA4 Ig plus donorspecific transfusion. J Exp Med, 1993; 178∶1801.
|
- 1. Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol, 1993; 11∶191.
- 2. 陈力真，王树蕙，张云等.人化SCID鼠的建立及其对脊髓灰质炎病毒的免疫应答.中华微生物学和免疫学杂志，1995； 15∶82.
- 3. Martin PJ, Ledbetter JA, Morishita Y, et al. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol, 1986; 136∶3282.
- 4. Damle NK, Doyle LV, Grosmaire LS, et al. Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes. J Immunol, 1988; 140∶1753.
- 5. Lin H, Bolling SF, Linsley PS, et al. Longterm acceptance of major histocompatbility complex mismatched cardiac allografts induced by CTLA4 Ig plus donorspecific transfusion. J Exp Med, 1993; 178∶1801.
