Objective To investigate the preparation of a chitosanencapsulated porus calcium polyphosphate (CPP) bioceramic so as to provide a feasible approach to repair of the bone defect. Methods The chitosan microspheres were produced by chemical procedures. The CPP bioceramic was made by the following steps: annealing, ball milling, admixing, and calcinating. The chemical method was used to encapsule the calcinated bioceramic by the porus chitosan film. The physicochemical property, biomechanical property, and toxicity of the chitosanencapsulated porus CPP bioceramic were analyzed. Results The uniform holes were observed in the CPP bioceramic under a microscope. The diameter of the hole was 100300 μm. The chitosan microballoons were amber in color. The particles were uniform with a diameter of 200-400 μm, with a poor compressive strength. They could be easily ground by hand. Themaximally tolerated dose of the CPP bioceramic leaching liquor given to the Jimpy mice of both sexes was  gt;24g/kg on average. The compressive strength reached 200 MPa, and the interval porosity was about 60％-80％, which could completely meet with the compressive strength of the bone substitute. Conclusion The chitosancncapsulated porous CPP bioceramic can be used as a good porous bioceramic scaffold material, which has a good biomechanical property withno acute toxicity, and so may be used as an excellent material for the bone substitute. 

Citation： FAN Changchun,LIU Dejun,REN Yunpeng,et al.. PREPARATION OF CHITOSANENCAPSULATED POROUS CALCIUM POLYPHOSPHATE BIOCERAMIC. Chinese Journal of Reparative and Reconstructive Surgery, 2007, 21(12): 1355-1358. doi: Copy

Copyright © the editorial department of Chinese Journal of Reparative and Reconstructive Surgery of West China Medical Publisher. All rights reserved