Objective To evaluate the diagnosis value of purified protein derivative (PPD) antibody tests in childhood tuberculosis.
Methods We reviewed 126 cases of hospitalization children tested body fluid PPD antibody by Enzyme-Linked Immunosorbent Assay (ELISA). Twenty-two them were diagnosed with tuberculosis. We determined the sensitivity, specificity, diagnostic likelihood ratio, positive prognostic value, negative prognostic value, post-test probability, respectively.
Results The following accuracy statistics for the PPD body liquid antibody tests in this study: sensitivity, 45.45%; specificity, 91.35%; diagnostic likelihood ratio positive, 5.25; diagnostic likelihood ratio negative, 0.597; positive predictive value, 52.63%; negative predictive value, 88.79% and post-test probability, 48.09% in 15% of prevalence.
Conclusion This study shows that body fluid PPD tests have limited value for diagnosis of tuberculosis in pediatric tuberculosis. Clinic physicians should be wary of the positive results of body fluid PPD antibody tests. The value of diagnosis is related to prevalence of tuberculosis in the specific hospital.
Citation：
XIA Jialing,ZHU Yu,DEN Jianjun,WAN Chaoming. The Body Fluid Purified Protein Derivative Antibody Tests: Diagnosis Value in Pediatric Tuberculosis. Chinese Journal of Evidence-Based Medicine, 2006, 06(7): 537-539. doi:
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- 1. 王家良, 主编. 临床流行病学. 第2版. 北京: 人民卫生出版社; 2004. 152-159.
- 2. 鲁启超, 董云秋. 血清抗结核分支杆菌抗体对结核病的诊断价值. 中华结核和呼吸杂志, 1998; 21(2): 82~84.
- 3. Miceli IN, Sequeira MD, de Kantor IN. Childhood tuberculosis and its diagnosis in Argentina. Medicina (B Aires), 2002; 62(6): 585-592.
- 4. WHO Report 2005. Global tuberculosis control:surveillance,planning,financing. London/ Geneva, 2005; 75-78.
- 5. Nassau E. Parsons ER, Johnson GD. The detection of antibodies to Mycobacterium tuberculosis by microplate enzyme-linked immunosorbent assay (ELISA). Tubercle, 1976; 57(1): 67-70.
- 6. Furin JJ, Johnson JL. Recent advances in the diagnosis and management of tuberculosis. Curr Opin Pulm Med, 2005; 11(3): 189-194.
- 7. No authors listed. Diagnostic standards and classification of tuberculosis in adults and children. This official statement of the American Thoracic Society and the Centers for Disease Control and Prevention was adopted by the ATS Board of Directors, July 1999. This statement was endorsed by the Council of the Infectious Disease Society of America, September 1999. Am J Respir Crit Care Med, 2000; 161(4 Pt 1): 1376-1395.
- 8. Wang JL, editor in chief. Clinical Epidemiology. 2nd edition. Beijing: People’s Medical Publishing House; 2004. 152-159.
- 9. WHO Tuberculosis Diagnostics Workshop. Product development guidelines. Workshop report, Cleveland, Ohio, 1997;1-27.
- 10. Gaudelus J. Tuberculosis in children. Rev Prat, 2002; 52(19): 2133-2138.
- 11. Lu QC, Dong YQ. Clinical significance of serum anti-Mycobacterium tuberculosis antibody in diagnosis of tuberculosis. Chin J Tuberc Respir Dis, 1998;21(2):82-84.
