目的:探讨PET-CT模拟定位对非小细胞肺癌合并肺不张适形调强放疗靶区确定的临床价值。方法:对经影像学和病理证实伴有肺不张的非小细胞肺癌12例患者,进行PET-CT模拟定位。根据PET-CT扫描显像结果,分别以GTV CT和GTVPET-CT勾画原发病灶,对用治疗计划系统计算出的两组数值加以比较。结果:GTVCT平均为141 cm3(99～185 cm3),GTVPET-CT平均为113 cm3(60～165 cm3),两者差异有显著性(t=5.497,P lt;0.001)。12例患者原发病灶体积的GTVPET-CT均较GTV CT有不同程度的缩小,平均缩小体积28 cm3(19%)。结论:PET-CT模拟定位,对非小细胞肺癌合并肺不张患者放疗靶区的精确定位具有重要的临床意义。
Citation：
LUO Jianhua,ZHOU Ke,XIAN Jing,et al. Value of Positron Emission Tomography - computed Tomographic Simulator Treated with Intensity Modulated Radiotherapy in Patients with Non-small Cell Lung Cancer Complicated with Atelectasis. West China Medical Journal, 2009, 24(4): 942-944. doi:
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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- 1. NESTLE U, WALTER K. 18F-deoxyglucose positron emission tomography (FDG-PET) for the planning of radiotherapy in lung cancer: high impact in patients with atelectasis[J]. Int J Radiat Oncol Biol Phys,1999,44:593-597..
- 2. THOMAS L P, BALINGIT A G,MORISON D S, et al. False- positive technetium 99m depreotide scintigraphy resulting from round atelectasis[J]. J Thorac Imaging,2003,18:97-99..
- 3. 王凯,王绿化,梁军,等.FDG PET对非小细胞肺癌合并肺不张三维适形放疗时靶区确定的临床意义[J].中华放射肿瘤学杂志,2006,15(1):11-14..
- 4. OGAWA MIKAKO. 18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study[J]. J Nucl Med,2004,45:1245-1250..
- 5. 宋吉清,张成琪.PET-CT对肺癌的临床应用进展[J].医学影像学杂志,2005,(15)1:66-68..
- 6. PIETERMAN R M, VAN PUTTEN J W. Preoperative staging of non-small-cell lung cancer with positron-emission tomography[J]. N Engl J Med,2000,343:254-261..
- 7. KAWABE J, OKAMURA T. Thallium and FDG uptake by atelectasis with bronchogenic carcinoma[J]. Ann Nucl Med,1999,13:273-276..
- 8. MCADAMS H P, ERASUMS J J. Evaluation of patients with round atelectasis using 2-[18F]- fluoro-2-deoxy-D-glucose PET[J]. J Comput Assist Tomogr,1998,22:601-604..
- 9. BRADLEY J, THORSTAD W L, MUTIC S, et al. Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer[J]. Int JRadiat Oncol Biol Phys,2004,59:78-86..
- 10. ERDI Y E, ROSENZWEIG K, ERDI A K, et al. Radiotherapy treatment planning for patients with non-small cell lung cancer using positron emissiontomography(PET)[J]. Radiother Oncol,2002,62:51-60..
- 11. 巩和义,于金明,付政,等.FDG PET对非小细胞肺癌合并肺不张三维适形放疗时靶区确定的临床意义[J].中华肿瘤杂志,2006,28(1):11-14.
