目的:评价双磷酸盐联合甲氨喋呤治疗绝经后类风湿关节炎患者疗效,分析治疗方法对类风湿关节炎活动度指标的影响。方法:选择2005～2007年我院住院及门诊的活动期类风湿关节炎患者75例,随机双盲分为2组,其中甲氨喋呤组45例,甲氨喋呤+双磷酸盐组30例。检测两组使用药物前后患者疾病活动性指标及血清中类风湿关节炎活动度相关指标,评价甲氨喋呤+双磷酸盐治疗方法的疗效。结果:甲氨喋呤+双磷酸盐治疗组可以提高骨密度,治疗后两组观察指标比较,甲氨喋呤+双磷酸盐组疾病活动度指标改善明显好于单用甲氨喋呤组。结论:双磷酸盐能有效防止骨丢失,帮助类风湿关节炎病情缓解。
Citation：
官晓红,胡谦,练颖,刘潇潇,陶黎,任丽蓉. 双磷酸盐联合甲氨喋呤治疗绝经后类风湿关节炎患者疗效观察. West China Medical Journal, 2009, 24(8): 2152-2153. doi:
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| 1. |
FORSBLAD-D’ELIA H,LARSEN A, WALTBRAND E, et al. Ann Rheum Dis,2003,62(7):617-623.
|
| 2. |
徐浩.绝经后女性类风湿性关节炎患者腰椎和股骨近端骨密度测量[J].中国骨质疏松杂志,1998,4(1):17-19.
|
| 3. |
HAUGEBERG,ORSTAVIK RE, KVIEN TK. Effects of rheumatoid arthritis on bone[J]. Curr Opin Rhenmatol,2003,15:469-475.
|
| 4. |
VALLEALA H,LAITINEN K,PYLKRANEN L,et al. Clinical and biochemical response to single infusion of clodronate in active rheumatoid arthritisa double blind placebo controlled study[J].Inflamm Res,2001,50(11):598-601.
|
| 5. |
KYLE RF,GUSTILO RB.American of rheumatology subcommitee on rheumtoid arthritis lsuidelines[J].Arthritis Rhem,2002,46(2):328-346.
|
- 1. FORSBLAD-D’ELIA H,LARSEN A, WALTBRAND E, et al. Ann Rheum Dis,2003,62(7):617-623.
- 2. 徐浩.绝经后女性类风湿性关节炎患者腰椎和股骨近端骨密度测量[J].中国骨质疏松杂志,1998,4(1):17-19.
- 3. HAUGEBERG,ORSTAVIK RE, KVIEN TK. Effects of rheumatoid arthritis on bone[J]. Curr Opin Rhenmatol,2003,15:469-475.
- 4. VALLEALA H,LAITINEN K,PYLKRANEN L,et al. Clinical and biochemical response to single infusion of clodronate in active rheumatoid arthritisa double blind placebo controlled study[J].Inflamm Res,2001,50(11):598-601.
- 5. KYLE RF,GUSTILO RB.American of rheumatology subcommitee on rheumtoid arthritis lsuidelines[J].Arthritis Rhem,2002,46(2):328-346.
