A Clinical Study of Fluoxetine Plus Mental Intervention in Cardiovascular Disease with Anxiety and Depression_West China Medical Journal

Authors：

XIA Nan , FAN Wenlan , WANG Haiyan.

the Psychiatry Department of Mental Health Center of Nantong, Nanchong Sichuan 637000, China;

Corresponding author：

Keywords：

抗抑郁剂; 心理干预; 心血管疾病; 焦虑抑郁

Video：

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目的:探讨氟西汀联合心理干预治疗心血管疾病患者伴焦虑抑郁症状的临床疗效。方法:选择伴有抑郁、焦虑情绪障碍的85例冠心病患者(心功能Ⅱ、Ⅲ级),并将其随机分成研究组和对照组。观察6w,对照组患者仅给予常规的治疗,研究组患者在常规治疗基础上给予氟西汀联合心理干预治疗。观察治疗前后两组患者采用汉密顿焦虑量表( Hamilton Anxiety Scale,HAMA) 评定焦虑症状,汉密顿抑郁量表( Hamilton Depression Scale,HAMD) 评定抑郁症状;并对治疗后心功能分级(NYHA)恢复到Ⅰ级的例数及左室射血分数进行分析评价。结果:治疗6 周后,研究组均较对照组的汉密顿焦虑量表及汉密顿抑郁量表评分下降显著( P lt;0.01),研究组抗焦虑显效率为87.16%、抗抑郁显效率为82.26%,对照组分别为43.75%、45.36%,研究组均显著高于对照组( P lt;0.01);研究组患者的左室射血分数显著高于对照组 ( P lt;0.05),心功能分级(NYHA)恢复到Ⅰ级的例数显著高于对照组 ( P lt;0.05)。结论:氟西汀联合心理干预治疗不仅能改善心血管疾病伴焦虑抑郁患者的焦虑、抑郁情绪障碍,还能改善患者的心功能,疗效显著优于单用心血管药物治疗。

Citation： XIA Nan,FAN Wenlan,WANG Haiyan.. A Clinical Study of Fluoxetine Plus Mental Intervention in Cardiovascular Disease with Anxiety and Depression. West China Medical Journal, 2009, 24(10): 2511-2513. doi: Copy

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8.	付朝伟, 徐飚, 栾荣生,等. 大城市综合医院冠心病人抑郁/ 焦虑影响因素探讨[J]. 卫生研究, 2006, 35(5):634-636.
9.	THURSTON RC, KUBZANSKY LD, KAWACHI I, et al . Do depression and anxiety mediate the link between educational attainment and CHD [J]. Psychosomatic Medicine, 2006, 68(1):25-32.
10.	BLUMENTAL WA, GOMEZCAMINERO A, RUSSO LJ, et al . Does panic disorder increase the risk of coronary heart disease? [J]. Psychosomatic Medicine, 2005, 67(5):688-691.
11.	乙伶, 姚淮芳. 抑郁与冠心病发病机制最新研究进展[J]. 中西医结合心脑血管病杂志2007, 5(10): 984-987.

1.
2. KOP W J, ADER D N. Assessment and treatment of depression in coronary artery disease patients[J]. Ital Heart J,2001,2(12):890-894.
3. THORNTON L A. Depression in postacute myocardial infarction patients [J]. J Am Acad Nurse Pract,2001,13(8):364-367.
4. 黄佐,樊民,吴宗贵.冠心病患者抑郁与冠状动脉病变的关系[J].中华心血管病杂志,2003,31(5):329.
5. 陈银娣,周天骍,施慎逊,等.老年冠心病病人焦虑、抑郁症状的调查[J].上海精神医学,2000,12(1):17-19.
6. PENNIX B W, BEEKMAN AARTJAN T F, HONIG ADRIAAN MD, et al . Depression and cardiac mortality:Results from a communitybased longitudinal study[J]. Arch Gen Psychiatry,2001,58(3):221-227.
7. GUMP B B, MATTHEWS K A, EBERLY L E, et al. Depression symptoms and mortality in men: Results from the multiple risk factor intervention trial[J]. Stroke, 2005(1), 36: 98-102.
8. 付朝伟, 徐飚, 栾荣生,等. 大城市综合医院冠心病人抑郁/ 焦虑影响因素探讨[J]. 卫生研究, 2006, 35(5):634-636.
9. THURSTON RC, KUBZANSKY LD, KAWACHI I, et al . Do depression and anxiety mediate the link between educational attainment and CHD [J]. Psychosomatic Medicine, 2006, 68(1):25-32.
10. BLUMENTAL WA, GOMEZCAMINERO A, RUSSO LJ, et al . Does panic disorder increase the risk of coronary heart disease? [J]. Psychosomatic Medicine, 2005, 67(5):688-691.
11. 乙伶, 姚淮芳. 抑郁与冠心病发病机制最新研究进展[J]. 中西医结合心脑血管病杂志2007, 5(10): 984-987.

West China Medical Journal

A Clinical Study of Fluoxetine Plus Mental Intervention in Cardiovascular Disease with Anxiety and Depression

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