Objective To explore the effect of fast track rehabilitation in patients with gastric cancer during perioperative period.
Methods Eighty patients were randomly divided into conventional method group (n=40) and fast track rehabilitation group (n=40), and to compare the levels of total lymphocyte count (TLC) , C-reaction protein (CRP),IgG, IgM, IgA, CD3+, CD4+, CD8+, and CD4+/CD8+ in serum on the days of 1 d before operation and 1 and 3 d after operation,and to record the duration of fever,first ventilation time of flatus, postoperative hospital stay time,and the postoperative complications.
Results The first ventilation time after operation was advanced in patients of fast track rehabilitation group, and the postoperative fever time and hospital stay time after operation of patients was shorter in fast track rehabilitation group than that in conventional method group (P<0.05). The incidence difference of complications in two groups had not statistic significance (P>0.05). The TLC on 1 d after operation were lower than that on 1 d before operation in two groups, and the CRP values of 1 d after operation were higher than that of 1 d before operation in two groups (P<0.01). Compared with 1 d before operation, the CRP value on 3 day after operation in fast track rehabilitation group was lower than that in conventional method group, and the levels of IgG, IgM, IgA, CD3+, CD4+, CD8+, and CD4+/CD8+ were higher than that in conventional group (P<0.05).
Conclusions Fast track surgery applied to patients with gastric cancer during perioperative period is safe and efficient, which can mitigate the immunologic impairment of patients and accelerate postoperative rehabilitation.
Citation:
WU Gang,YE Xiangyang,SUN Shaozhen,FAN Yi,GUO Jin.. Discussion with Clinical Application for Fast Track Rehabilitation Concept in Treatment of Patients with Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(6): 657-661. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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Kehlet H. Future perspectives and research initiatives in fasttrack surgery [J]. Langenbecks Arch Surg, 2006, 391(5):495-498.
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杨廷翰, 蒲怡, 赵娜, 等. 高龄结直肠癌患者快速流程的随机对照研究 [J]. 中国普外基础与临床杂志, 2010, 17(9):983-988.
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Darido EF, Farrell TM. Fast-track concepts in majar open upper abdominal and thoraco abdominal surgery:a review [J]. World J sarg, 2011, 35(12):2594-2595.
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Muller S, Zalunardo MP, Hubner M, et al. A fast-track program reduces complications and length of Hospital stay after open colonic surgery [J]. Gastroenterology, 2009, 136(3):842-847.
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Timothy M, Geiger MD, Graham Mackay Mbch B, et al. Outcomes of fast-track pathways for open and laparoscopic surgery[J]. Seminars Colon Rect Surg, 2010, 21(3):170-175.
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胡祥. 第14 版日本《胃癌处理规约》的重要变更 [J]. 中国实用外科杂志, 2010, 30(4):241-246.
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江志伟, 黎介寿, 汪志明, 等. 胃癌患者运用加速康复外科治疗的安全性及有效性研究[J]. 中华外科杂志, 2007, 45(19):1314-1317.
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Wang Q, Suo J, Jiang J, et al. Effetiveness of fast track rehabilitation vs. conventional care in laparoscopic colorectal resection for elderly patients:a randonized trial [J]. Colorectal Dis,2011, 10(11):1463-1468.
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傅平, 周凯, 袁喜江, 等. 加速康复外科方案与传统方案治疗老年胃癌患者的对比研究 [J]. 实用医学杂志, 2010, 26(17):3145-3147.
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徐俊, 陈超, 熊非, 等. 快速流程模式对直肠癌不同手术方案的临床疗效影响 [J]. 中国普外基础与临床杂志, 2011, 18(9):961-965.
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杨廷翰, 蒲怡, 杨光超, 等. 快速流程完成率对结直肠癌根治术术后管理的影响 [J]. 中国普外基础与临床杂志, 2010,17(11):1203-1212.
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王东升, 周岩冰, 孔营, 等. 加速康复外科对胃癌患者免疫功能及临床结局的影响 [J]. 中华普通外科杂志, 2009, 24(7):554-556.
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姜洪池, 朱化强. 重视腹部外科手术后下肢深静脉血栓形成和肺栓塞的防治 [J]. 中国实用外科杂志, 2010, 30(12):989-991.
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Soop M, Nygren J, Myrenfors P, et al. Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin eesistance [J]. Am J Physiol Endocrinol Metab, 2001, 280(4):E576-E583.
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王建中, 江志伟, 鮑扬, 等. 胃肠道手术中不常规留置胃肠减压管并早期进食的临床应用研究 [J]. 中国实用外科杂志,2009, 29(4):331-332.
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董春梅. 快速康复外科方法在胃肠道手术中的应用研究 [J].齐齐哈尔医学院学报, 2010, 31(2):192-193.
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华莹奇, 张治宇, 蔡郑东. 快速康复外科理念在骨科的应用现状与展望 [J]. 中华外科杂志, 2009, 47(19):1505-1508.
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吴国豪. 重视老年普通外科病人围手术期处理 [J]. 中国实用外科杂志, 2009, 29(2):109-111.
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21. |
Caril F, Kehlet H, Ballini G, et al. Evindence basis for regional anesthesia in multidisciplinary fast-track surgical care pathways [J]. Reg Anesth pain Med, 2011, 36(1):63-72.
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22. |
Jin F, Chung F. Multimodal analgesia for postoperative pain control [J]. J Clin Anesth, 2001, 13(7) :524-539.
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23. |
廖雪莲, 康焰. 重症患者的液体治疗 [J]. 中华外科杂志,2009, 47(6):432-434.
|
24. |
肖凌, 黄真真, 李蔚, 等. 快速流程模式中术后限制补液在老年结直肠癌患者中的应用价值 [J]. 中国普外基础与临床杂志, 2010, 17(1):87-91.
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25. |
肖凌, 汪晓东, 李立. 术后液体管理在结直肠外科快速流程中的应用进展 [J]. 中国普外基础与临床杂志, 2009, 16(7):593-596.
|
26. |
姜洪池, 王刚. 快速康复外科理念在原发性肝癌围手术期的应用 [J]. 中国实用外科杂志, 2010, 48(20):1521-1523.
|
- 1. Gralla O, Haas F, Knoll N, et al. Fast-track surgery in laparoscopic radical prostatectomy:basic principles [J]. World J Urol, 2007, 25(2):185-191.
- 2. Kehlet H. Future perspectives and research initiatives in fasttrack surgery [J]. Langenbecks Arch Surg, 2006, 391(5):495-498.
- 3. 杨廷翰, 蒲怡, 赵娜, 等. 高龄结直肠癌患者快速流程的随机对照研究 [J]. 中国普外基础与临床杂志, 2010, 17(9):983-988.
- 4. 江志伟, 李宁, 黎介寿. 加速康复外科的概念及临床意义 [J].中国实用外科杂志, 2007, 27(2):131-133.
- 5. Darido EF, Farrell TM. Fast-track concepts in majar open upper abdominal and thoraco abdominal surgery:a review [J]. World J sarg, 2011, 35(12):2594-2595.
- 6. Muller S, Zalunardo MP, Hubner M, et al. A fast-track program reduces complications and length of Hospital stay after open colonic surgery [J]. Gastroenterology, 2009, 136(3):842-847.
- 7. Timothy M, Geiger MD, Graham Mackay Mbch B, et al. Outcomes of fast-track pathways for open and laparoscopic surgery[J]. Seminars Colon Rect Surg, 2010, 21(3):170-175.
- 8. 胡祥. 第14 版日本《胃癌处理规约》的重要变更 [J]. 中国实用外科杂志, 2010, 30(4):241-246.
- 9. 江志伟, 黎介寿, 汪志明, 等. 胃癌患者运用加速康复外科治疗的安全性及有效性研究[J]. 中华外科杂志, 2007, 45(19):1314-1317.
- 10. Wang Q, Suo J, Jiang J, et al. Effetiveness of fast track rehabilitation vs. conventional care in laparoscopic colorectal resection for elderly patients:a randonized trial [J]. Colorectal Dis,2011, 10(11):1463-1468.
- 11. 傅平, 周凯, 袁喜江, 等. 加速康复外科方案与传统方案治疗老年胃癌患者的对比研究 [J]. 实用医学杂志, 2010, 26(17):3145-3147.
- 12. 徐俊, 陈超, 熊非, 等. 快速流程模式对直肠癌不同手术方案的临床疗效影响 [J]. 中国普外基础与临床杂志, 2011, 18(9):961-965.
- 13. 杨廷翰, 蒲怡, 杨光超, 等. 快速流程完成率对结直肠癌根治术术后管理的影响 [J]. 中国普外基础与临床杂志, 2010,17(11):1203-1212.
- 14. 王东升, 周岩冰, 孔营, 等. 加速康复外科对胃癌患者免疫功能及临床结局的影响 [J]. 中华普通外科杂志, 2009, 24(7):554-556.
- 15. 姜洪池, 朱化强. 重视腹部外科手术后下肢深静脉血栓形成和肺栓塞的防治 [J]. 中国实用外科杂志, 2010, 30(12):989-991.
- 16. Soop M, Nygren J, Myrenfors P, et al. Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin eesistance [J]. Am J Physiol Endocrinol Metab, 2001, 280(4):E576-E583.
- 17. 王建中, 江志伟, 鮑扬, 等. 胃肠道手术中不常规留置胃肠减压管并早期进食的临床应用研究 [J]. 中国实用外科杂志,2009, 29(4):331-332.
- 18. 董春梅. 快速康复外科方法在胃肠道手术中的应用研究 [J].齐齐哈尔医学院学报, 2010, 31(2):192-193.
- 19. 华莹奇, 张治宇, 蔡郑东. 快速康复外科理念在骨科的应用现状与展望 [J]. 中华外科杂志, 2009, 47(19):1505-1508.
- 20. 吴国豪. 重视老年普通外科病人围手术期处理 [J]. 中国实用外科杂志, 2009, 29(2):109-111.
- 21. Caril F, Kehlet H, Ballini G, et al. Evindence basis for regional anesthesia in multidisciplinary fast-track surgical care pathways [J]. Reg Anesth pain Med, 2011, 36(1):63-72.
- 22. Jin F, Chung F. Multimodal analgesia for postoperative pain control [J]. J Clin Anesth, 2001, 13(7) :524-539.
- 23. 廖雪莲, 康焰. 重症患者的液体治疗 [J]. 中华外科杂志,2009, 47(6):432-434.
- 24. 肖凌, 黄真真, 李蔚, 等. 快速流程模式中术后限制补液在老年结直肠癌患者中的应用价值 [J]. 中国普外基础与临床杂志, 2010, 17(1):87-91.
- 25. 肖凌, 汪晓东, 李立. 术后液体管理在结直肠外科快速流程中的应用进展 [J]. 中国普外基础与临床杂志, 2009, 16(7):593-596.
- 26. 姜洪池, 王刚. 快速康复外科理念在原发性肝癌围手术期的应用 [J]. 中国实用外科杂志, 2010, 48(20):1521-1523.