Objective To explore the value of chemosensitivity assay in vitro on breast cancer. Methods In vitro chemosensitivity of 6 species of chemotherapeutic agents applied to 38 cases of breast cancer patients were detected by tissue culture-end point staining-computer image analysis (TECIA). Results The sensitivity to chemotherapeutic agents commonly used in the breast cancer level from high to low was as follow: Doxorubicin (ADM), Paclitaxel (TAX), Vinorelbine (NVB), Cyclophosphamide (CTX), Cisplatin (DDP) and Fluorouracil (FU). Conclusion Drugs sensitivity experiment of cancer in vitro by TECIA has an important value to instruct clinical medication and individual chemotherapy for breast cancer.
Citation:
HUANG Zhengyou,LI Zhiwen,QIN Yunrong. Value of Chemosensitivity Assay In Vitro on Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(2): 145-147. doi:
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- 1. 尹有群, 王晓文, 卢义生, 等. TECIA法在肿瘤组织药敏试验中的应用[J]. 实用医技杂志, 2007; 14(7): 838.
- 2. 姜军.乳腺癌临床治疗策略的研究进展[J].中国普外基础与临床杂志, 2004; 11(1): 1.
- 3. 魏寿江, 王崇树, 赵国刚, 等.大肠癌化疗药物敏感性与病人年龄及性别的关系[J].西部医学, 2003; 1(1): 30.
- 4. 刘冀龙, 董新舒, 刘忠臣, 等.应用RT-PCR方法定量分析大肠癌患者多药耐药基因表达水平及其临床意义[J].中国肿瘤临床, 1999; 26(1): 39.
- 5. 赵菲, 姜军.乳腺癌多药耐药性研究进展[J].中国普外基础与临床杂志, 2004; 11(1): 36.
- 6. 姚榛祥.乳腺癌诊治的进展[J].中国普外基础与临床杂志, 2002; 9(5): 293.
- 7. 葛勇前, 何志明, 凌云华, 等.MTT法研究化疗药物对人胃癌细胞株的药效动力学特征[J]. 中国临床药学杂志, 2000; 9(2): 101.
- 8. Kabeshima Y, kubota T, Watanabe M, et al. Clinical usefulness of chemosensitivity test for advanced colorectal cancer [J]. Anticancer Res, 2002; 22(5): 3033.
- 9. Taylor CG, Sargent JM, Elgie AW, et al. Chemosensitivity testing predicts survival in ovarian cancer [J]. Eur J Gynaecol Oncol, 2001; 22(4): 278.
- 10. 赵小华, 张为强, 蒋阳平, 等.MTT法药敏试验应用于晚期乳腺癌[J]. 中国肿瘤, 2003; 12(8): 479.