Objective To study the medicine dynamics, distribution in tissue and abdominal cavity fluid concentration of 5-FU after giving intraperitoneal by using a gelatin carrier to be made 5-FU slowing-release microballoons.
Methods 5-FU slowing-release microballoons medicine release speed, tissue distributing and the concentration in abdominal cavity fluid were measured by high performance liquid chromatography.
Results 5-FU wrapped by gelatin were slowly released. The concentration in abdominal cavity fluid was obviously higher than that in tissue or in blood. Using established standard curve line, it was proved that in body area under curve (AUC) of 5-FU slowing-release microballoons group was obviously higher than that of simple 5-FU injection group, analyzed by 3p97 pharmacokinetic software management.
Conclusion 5-FU enwrapped by gelatin can retain an effective anticancer activity concentration in abdominal cavity 7 days after giving intraperitoneal and it is distributed mostly in abdominal cavity.
Citation：
LIANG Huaizhu,LI Ye,ZHU Shibin. Animal Experiment of 5-FU Slowing-Release Microballoons Given Intraperitoneal. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(10): 748-750. doi:
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| 1. |
刘晖， 钱振宇， 吴昊， 等. 腹腔灌洗液中端粒酶活性和CA125水平的测定在诊断胃癌腹膜转移中的应用 [Ｊ]. 中国医师进修杂志, 2007; 30(10)∶5.
|
| 2. |
李晓平, 卜双龙, 李朝龙. 腹腔化疗在腹腔消化系恶性肿瘤的治疗作用 [Ｊ]. 第一军医大学学报， 2000; 20(4)∶375.
|
| 3. |
崔福德主编. 药剂学 [M]. 第5版. 北京: 中国科技出版社,2002∶457~484.
|
| 4. |
韩锐主编. 抗癌药物研究与实验技术 [M]. 北京: 北京医科大学出版社, 1997∶258~259.
|
| 5. |
Kim DY, Seo KW, Joo JK, et al. Prognostic factors in patients with node-negative gastric carcinoma: a comparison with node-positive gastric carcinoma [Ｊ]. World J Gastroenterol, 2006; 12(8)∶1182.
|
| 6. |
Broll R, Weschta M, Windhoevel U, et al. Prognostic significance of free gastrointestinal tumor cells in peritoneal lavage detected by immunocytochemistry and polymerase chain reaction [Ｊ]. Langenbecks Arch Surg, 2001; 386(4)∶285.
|
| 7. |
邱文才， 王维刚， 王志刚， 等. 胃癌术中盆腹膜取材检测微转移及其临床意义评估 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(1)∶27.
|
- 1. 刘晖， 钱振宇， 吴昊， 等. 腹腔灌洗液中端粒酶活性和CA125水平的测定在诊断胃癌腹膜转移中的应用 [Ｊ]. 中国医师进修杂志, 2007; 30(10)∶5.
- 2. 李晓平, 卜双龙, 李朝龙. 腹腔化疗在腹腔消化系恶性肿瘤的治疗作用 [Ｊ]. 第一军医大学学报， 2000; 20(4)∶375.
- 3. 崔福德主编. 药剂学 [M]. 第5版. 北京: 中国科技出版社,2002∶457~484.
- 4. 韩锐主编. 抗癌药物研究与实验技术 [M]. 北京: 北京医科大学出版社, 1997∶258~259.
- 5. Kim DY, Seo KW, Joo JK, et al. Prognostic factors in patients with node-negative gastric carcinoma: a comparison with node-positive gastric carcinoma [Ｊ]. World J Gastroenterol, 2006; 12(8)∶1182.
- 6. Broll R, Weschta M, Windhoevel U, et al. Prognostic significance of free gastrointestinal tumor cells in peritoneal lavage detected by immunocytochemistry and polymerase chain reaction [Ｊ]. Langenbecks Arch Surg, 2001; 386(4)∶285.
- 7. 邱文才， 王维刚， 王志刚， 等. 胃癌术中盆腹膜取材检测微转移及其临床意义评估 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(1)∶27.
