Objective To study the regulative effect of angelica sinensis on cellular immune function in perioperative patients with obstructive jaundice.
Methods Fourteen patients with obstructive jaundice were injected with angelica before and after operation for 14 days. The activity of IL-2 and the expression of IL-2R in lymphocytes in peripheral blood were measured, respectively.
Results The activity of IL-2 and the expression of IL-2R decreased significantly in patients with obstructive jaundice (P＜0.01). The activity of IL-2 and the expression of IL-2R in peripheral blood lymphocyte increased significantly before and after operations (after treatment using angelica) (P＜0.01), though there was a little decrease after operation but they were still higher than that befor using angelica.
Conclusion It maybe useful to use angelica to improve the cellular immune function in patients with obstructive jaundice.
Citation：
LI Yanguang,ZOU Shengquan. Effect of Angelica Sinensis on Cellular Immunity in Patients with Obstructive Jaundice. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(4): 456-458. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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杜俊蓉， 白波， 余彦， 等. 当归挥发油研究新进展[J]. 中国中药杂志， 2005； 30(18)∶1400.
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- 1. 8 李立， 禚守蓉. XGD-1对人外周血T淋巴细胞增殖和IL-2R表达的影响 [J]. 中国普外基础与临床杂志， 2003； 10（3）∶230
9 董岩， 魏兴国， 崔庆新， 等. 当归挥发油化学成分分析 [J]. 山东中医杂志， 2004； 23（1）∶43.
- 2. Nehez L, Andersson R. Compromise of immune function in obstructive jaundice[J]. Eur J Surg， 2002; 168(6)∶315.
- 3. 吴言涛. 梗阻性黄疸的围手术期处理 [J]. 中国普外基础与临床杂志， 2003； 10（3）∶183.
- 4. 杨林， 谢晓东， 王朝华， 等. 经皮肝穿胆道引流术治疗恶性梗阻性黄疸 [J]. 中国普外基础与临床杂志， 2004； 11（4）∶299.
- 5. Karan B, Kama NA, Hascelik G, et al. Effects of vitamin A on immunological deficiencies in rats with obstructive jaundice[J]. Eur J Surg， 1996; 162(3)∶217.
- 6. Roughneen PT, Gouma DJ, Kulkarni AD, et al. Impaired specific cell-mediated immunity in experimental biliary obstruction and its reversibility by internal biliary drainage[J]. J Surg Res， 1986; 41(2)∶113.
- 7. 丁显仲， 李桦， 熊叔陶， 等. 恶性阻塞性黄疸患者外周血淋巴细胞IL-2产生及IL-2R表达 [J]. 中国肿瘤临床, 1995； 22（2）∶91.
- 8. Cousins DJ, Lee TH, Staynov DZ. Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines [J]. J Immunol， 2002; 169(5)∶2498.
- 9. 冯景奇， 柳钟勋， 左增艳， 等. 当归多糖及当归内酯对小鼠细胞免疫功能的影响 [J]. 中国免疫学杂志， 1998； 14(4)∶279.
- 10. 王本祥. 现代中药药理与临床 [M]. 第1版. 天津： 天津科技翻译出版公司， 2004∶582~590.
- 11. Liu CX, Xiao PC, Li DP. Modern research and applicationof chinese medical plants [M]. The first edition. Hang Kong Medical Publisher， 2000∶166.
- 12. 杜俊蓉， 白波， 余彦， 等. 当归挥发油研究新进展[J]. 中国中药杂志， 2005； 30(18)∶1400.
