【Abstract】ObjectiveTo investigate the relevant factors for fungal infection following pancreatoduodenectomy and offer the theoretical foundation for preventing the emergence of complications after operation．
MethodsMedical records from 562 consecutive patients who underwent pancreatoduodenectomy in this hospital from 1995 to 2005 were retrospectively reviewed by using single factor and noncondition Logistic regression analyse.
Results①Seventyeight patients (13.9%) developed invasive fungal infection. The most frequently isolated fungal were Candida albicans accounted for 67.0%， and followed by Candida glabrata, Candida papasilosis and Candida tropicalis and gastrointestinal tract was the most common infection site, followed by respiratory tract, abdominal cavity. ②Fungal infection occurred significantly more often in patients with the length of time in parenteral nutrition, antibiotic use or abdominal cavity complications.
Conclusion The most common infection site and isolated fungal associated with pancreatoduodenectomy were gastrointestinal tract and Candida albicans. Abdominal cavity complications such as pancreatic fistula， biliary fistula and abdominal infection and extended use parenteral nutrition and antibiotic are the most important factors leading to invasive fungal infection after pancreatoduodenctomy. Eliminating the various risk factors will decrease the incidence of fungal infection.
Citation：
DUAN Shigang,CHEN Ping,LI Ying,DING Jiming,ZHANG Lin.. Factors Associated with Fungal Infection Following Pancreatoduodenectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(3): 317-320. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
| 1. |
[Ｊ].Int J STD AIDS, 1996； 7(Suppl l)∶ 13.
|
| 2. |
[Ｊ]. World J Surg,1999; 23(9)∶907.
|
| 3. |
[M]. 北京: 人民卫生出版社, 1998∶553~555.
|
| 4. |
[Ｊ]. J Antimicrob Chemother, 1991; 28(Suppl A)∶1.
|
| 5. |
|
| 6. |
[Ｊ]. J Clin Microbiol， 2002； 40(3)∶852.
|
| 7. |
[Ｊ]. Arch Surg， 1999; 134(6)∶657.
|
| 8. |
[Ｊ]. Arch Surg, 2001; 136(12)∶1401.
|
| 9. |
[Ｊ]. Dig Surg， 2000; l7(6)∶571.
|
| 10. |
[Ｊ].Intensive Care Med，1998; 24(3)∶206.
|
| 11. |
Mashkilleyson AL, Gomberg MA, Mashkilleyson N, et al.Treatment of syphilis with azithromycin.
|
| 12. |
Yeo CJ, Cameron JL．Improving results of pancreaticoduodenectomy for pancreatic cancer.
|
| 13. |
李梦东,张乃昌， 主编．实用传染病学.
|
| 14. |
Richardson MD．Opportunistic and pathogenic fungi.
|
| 15. |
Pfaller MA, Diekema DJ, Jones RN, et al.Trends in antifungal susceptibility of Candida spp. isolated from pediatric and adult patients with bloodstream infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000.
|
| 16. |
Borzotta AP, Beardsley K．Candida infections in critically ill trauma patients: a retrospective casecontrol study.
|
| 17. |
McKinnon PS, Goff DA, Kern JW, et al.Temporal assessment of Candida risk factors in the surgical intensive care unit.
|
| 18. |
Lehocky P, Sarr MG. Early enteral feeding in severe acute pancreatitis: can it prevent secondary pancreatic (super) infection?.
|
| 19. |
Vincent JL, Anaissie E, Bruining H, et al. Epidemiology, diagnosis and treatment of systemic Candida infection in surgical patients under intensive care.
|
- 1. [Ｊ].Int J STD AIDS, 1996； 7(Suppl l)∶ 13.
- 2. [Ｊ]. World J Surg,1999; 23(9)∶907.
- 3. [M]. 北京: 人民卫生出版社, 1998∶553~555.
- 4. [Ｊ]. J Antimicrob Chemother, 1991; 28(Suppl A)∶1.
- 5.
- 6. [Ｊ]. J Clin Microbiol， 2002； 40(3)∶852.
- 7. [Ｊ]. Arch Surg， 1999; 134(6)∶657.
- 8. [Ｊ]. Arch Surg, 2001; 136(12)∶1401.
- 9. [Ｊ]. Dig Surg， 2000; l7(6)∶571.
- 10. [Ｊ].Intensive Care Med，1998; 24(3)∶206.
- 11. Mashkilleyson AL, Gomberg MA, Mashkilleyson N, et al.Treatment of syphilis with azithromycin.
- 12. Yeo CJ, Cameron JL．Improving results of pancreaticoduodenectomy for pancreatic cancer.
- 13. 李梦东,张乃昌， 主编．实用传染病学.
- 14. Richardson MD．Opportunistic and pathogenic fungi.
- 15. Pfaller MA, Diekema DJ, Jones RN, et al.Trends in antifungal susceptibility of Candida spp. isolated from pediatric and adult patients with bloodstream infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000.
- 16. Borzotta AP, Beardsley K．Candida infections in critically ill trauma patients: a retrospective casecontrol study.
- 17. McKinnon PS, Goff DA, Kern JW, et al.Temporal assessment of Candida risk factors in the surgical intensive care unit.
- 18. Lehocky P, Sarr MG. Early enteral feeding in severe acute pancreatitis: can it prevent secondary pancreatic (super) infection?.
- 19. Vincent JL, Anaissie E, Bruining H, et al. Epidemiology, diagnosis and treatment of systemic Candida infection in surgical patients under intensive care.
