目的 总结胰腺实性假乳头状瘤（solid-pseudopapillary tumor of pancreas, SPTP）的诊治经验。方法 回顾性分析我院1999年11月至2007年10月期间收治的6例SPTP患者的临床资料。结果 6例均为女性，其中4例为年轻女性； 术前均未确诊； 行胰腺体尾部切除2例，肿瘤局部切除4例，其中2例加脾切除，术后病理报告确诊为SPTP。 术后无严重并发症，随访1～95个月，无复发和转移。结论 SPTP多发于年轻女性，术中冰冻切片对术中处理提供参考，手术切除为首选治疗方法，预后良好。
Objective To summarize the current diagnostic and therapeutic advancement of solid pseudopapillary tumor of the pancreas. Methods Relevant literatures about the diagnosis and treatment of solid pseudopapillary tumor of the pancreas, which were published recently domestic and abroad were collected and reviewed. Results Solid pseudopapillary tumor of the pancreas is now considered to be a low-grade malignancy with characteristic clinical, imaging and pathological features. Resection is considered to be the optimal choice with favourable prognosis. Conclusion An awareness of the features may guide us to a correct diagnosis and treatment of this rare neoplasm, but the deep understanding of the disease needs the accumulation of more cases and fundamental research.
目的：探讨鼻内镜手术治疗鼻内翻性乳头状瘤(NIP)的疗效。方法：回顾性分析用鼻内镜手术治疗的36例经病理确诊的NIP患者的临床资料，随访1～6年。结果:”一次性治愈31例(86.1%)；5例复发(13.9%)，3例在门诊内窥镜下分次摘除并结合YAG激光治愈，2例再次于鼻内镜结合Caidwell-Luc手术治疗，无恶变病例，结论：根据病变范围选择适当的手术方式，经鼻内镜手术切除鼻腔鼻窦内翻性乳头状瘤效果良好。
目的 总结胰腺实性假乳头状瘤再次手术病例的诊断和治疗经验。方法 回顾性分析2002年12月至2011年12月期间笔者所在医院收治的4例胰腺实性假乳头状瘤再次手术患者的临床资料。结果 4例患者均行手术治疗，术后恢复良好，随访时间3个月～8年，平均47个月。至2012年3月，3例患者分别无瘤生存3个月、3个月以及8年；1例患者于术后8年死于营养吸收障碍，死亡时无肿瘤复发。结论 胰腺实性假乳头状瘤具有低度恶性倾向，以局部复发为主，远处转移少见。手术是复发、转移病例的最佳选择，具有较好疗效。
目的总结胰腺实性假乳头状瘤的临床特点及诊治体会。方法回顾性分析2000年5月至2010年5月期间在我科手术治疗并经病理检查证实的8例胰腺实性假乳头状瘤患者的临床资料。结果3例肿瘤位于胰头部者行胰十二指肠切除术; 2例肿瘤位于胰颈部者行单纯肿瘤摘除术; 1例肿瘤位于胰体部者行胰腺中段切除、近端闭合、远端与空肠行吻合术; 2例位于胰尾部者行胰体尾切除联合脾脏切除术。 术中未见腹腔脏器转移。8例患者术后经病理检查均证实为胰腺实性假乳头状瘤。 术后均未行放、化疗。 本组患者随访1~10年（平均5.5年），除2例失访外，其余均健在。 结论胰腺实性假乳头状瘤临床少见，属低度恶性肿瘤，女性多见； CT及MRI是其主要的影像学检查手段； 手术切除预后较好。
To analyze the CT features of solid pseudopapillary tumor of pancreas (SPTP), and correlation with the pathological findings of the disease so as to improve the diagnostic abilities, the CT images and the clinical manifestations, we retrospectively analyzed the pathological materials of 23 cases with surgery and pathology proved SPTP. In the 23 patients, 21 cases were female (91.3%) and 2 were male (8.7%). The most common symptom was abdominal discomfort with dull pain in 12 patients (52.2%). Others included the pancreatic mass that was detected incidentally during physical examination in 9 patients (39.1%), nausea/vomiting in 2 patients (8.7%). And 1 case of female patients had 2 lesions. In the 24 tumors, 6 cases were located at the head (25.0%), 3 were at neck (12.5%), 8 cases were at body (33.3%), and 7 cases were at tail of pancreas respectively (29.2%). The long-axis diameter ranged from 2.1cm to 20.1cm (mean 6.4cm). 9 tumors were mostly solid component (37.5%), 10 tumors were contained similar proportion of solid and cystic part (41.7%), and mainly cystic components in 5 tumors (20.8%). In 9 of the 23 patients, calcification was found in the tumor (39.1%). In 2 of the 23 patients, bleeding was seen in the mass (8.7%). The dilation of intrahepatic bile duct was found in 1 patient (8.7%). Liver metastasis was showed in one patient (8.7%). On post-contrast CT scan, solid parts demonstrated mild enhancement at the arterial phase. At the portal phase, solid parts were enhanced continuously in all cases, and the enhancement degrees were lower than normal pancreatic tissue. The cystic parts of all lesions showed no enhancement. Pseudo papillary structure, hemorrhage, necrosis, or cystic degeneration were found in all patients by histological study. In a word, SPTP has comparatively characteristic CT imaging features consistent with histological features, when combined with clinical manifestations, could be correctly diagnosed and differentially diagnosed.
目的 探讨内镜下治疗胆管乳头状瘤的价值。方法 6例经病理学检查证实的胆管乳头状瘤患者在行“胆道探查+ T管引流术”后6～8周行胆道镜下高频电刀烧灼术，对术后治疗效果进行评估。结果 6例患者术后胆汁引流量逐渐增多至100～400 ml/d(平均250 ml/d)，胆汁黏稠度明显减轻，黄疸减退。术后随访1～3年，平均2年，3例患者术后黄疸、腹痛明显减轻，至今无复发； 2例在继续治疗中； 1例患者随访半年，T管引流通畅，但因严重肺部感染并发多器官功能衰竭死亡。结论 内镜下高频电刀烧灼治疗胆管乳头状瘤能有效缓解患者的临床症状，明显提高患者的生存质量。
【Abstract】ObjectiveTo detect the expression of human papilloma virus(HPV) 16 E7 was detected in colorectal adenocarcinoma tissue and normal mucosa. MethodsEighty-two patients with primary colorectal adenocarcinoma were selected in this study. The samples were taken from the tumor and the adjacent normal mucosa (10 cm away from the tumor) in each patient. Polymerase chain reaction (PCR) and immunohistochemistry were used to detect HPV16 E7 DNA and protein respectively. ResultsHPV16 E7 DNA expression was significantly higher in colorectal carcinoma (51.22%,42/82) than that in adjacent normal mucosa (4.88%,4/82), P＜0.01. A correlation was found between HPV16 E7 DNA expression and tumor location (P＜0.05)，18.18% in the ascending colon carcinoma and 64.10% in the rectal carcinoma. HPV16 E7 DNA expression was also associated with Dukes stage（P＜0.01）, but was not correlated with cancer differentiation. HPV16 E7 protein expression was mainly dectected in the nuclei of tumor cells with immunohistochemistry. There was a correlation between the expression of HPV16 E7 protein and HPV16 E7 gene. PCR had a higher sensitivity than immunohistochemistry. ConclusionHPV16 infection rate is much higher in the colorectal carcinoma than that in the adjacent normal mucosa, which indicates that HPV16 infection exists in some colorectal carcinomas. The high infection rate of HPV16 E7 is associated with advanced Dukes stage and proximity to anus.