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find Keyword "帕金森病" 61 results
  • 帕金森病合并痛风致关节溃疡护理一例

    Release date:2016-09-08 09:27 Export PDF Favorites Scan
  • Quantitative analysis of macular retinal thickness and volume in patients with different degrees of Parkinson’s disease

    ObjectiveTo observe the macular retinal thickness and volume in patients with different degrees of Parkinson's disease (PD).MethodsThirty eyes of 30 patients with primary PD and 20 eyes of 20 healthy subjects (control group) in Xuanwu Hospital of Capital Medical University from October 2016 to October 2017 were enrolled in this study. There were 17 males and 13 females, with the mean age of 63.2±6.4 years and disease course of 3.9±2.4 years. The patients were divided into mild to moderate PD group (15 eyes of 15 patients) and severe PD group (15 eyes of 15 patients). The macular area was automatically divided into 3 concentric circles by software, which were foveal area with a diameter of 1 mm (inner ring), middle ring of 1 to 3 mm, and outer ring of 3 to 6 mm. The middle and outer ring were divided into 4 quadrants by 2 radiations, respectively. The changes of retinal thickness and macular volume of the macular center and its surrounding quadrants were analyzed. SPSS 16.0 software was used for statistical analysis. One-way ANOVA were used to analyze all data.ResultsCompared with the control group, the retinal thickness and volume in macular center and each quadrant of the mild to moderate PD group and severe PD group were reduced. Compared with the mild to moderate PD group, the retinal thickness and volume in macular center and each quadrant of the severe PD group were reduced. The differences of retinal thickness and macular volume among 3 groups were significant (F=5.794, 5.221, 5.586, 5.302, 5.926, 5.319, 5.404, 5.261, 5.603; P=0.001, 0.007, 0.003, 0.005, 0.000, 0.004, 0.004, 0.006, 0.002). In inner ring of the mild to moderate PD group and the severe PD group, the retinal thickness and macular volume in the upper and the nasal were the largest, the inferior was followed, and the temporal was the smallest. In outer ring of the mild to moderate PD group and the severe PD group, the retinal thickness and macular volume in the nasal was the largest, the upper was the second, the temporal and the inferior were the smallest.ConclusionsThe retinal thickness and volume of the macular central fovea and its surrounding areas in PD patients are significantly thinner than that in the healthy subjects. And with the increase of the severity of PD, the macular structure changes obviously, showing macular center and its surrounding macular degeneration thin, macular volume reduced.

    Release date:2019-05-17 04:15 Export PDF Favorites Scan
  • Evidence of Therapy of Early Parkinson's Disease

    Patients with early Parkinson's disease should be treated rationally in order to improve their quality of life and reduce the motor complications. The early employment of drugs which provides sustained central dopamine agonism and dopaminergic neuroprotection may reach this aim to some extent. Evidence of effective therapy in early Parkinson's disease will be introduced including: dopamine agonists, monoamine oxidase inhibitor 13, coenzymeQ10, L-dopa and a gait training.

    Release date:2016-09-07 02:26 Export PDF Favorites Scan
  • 神经系统相关慢病的临床研究

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  • Resting-state electroencephalogram relevance state recognition of Parkinson’s disease based on dynamic weighted symbolic mutual information and k-means clustering

    At present, the incidence of Parkinson’s disease (PD) is gradually increasing. This seriously affects the quality of life of patients, and the burden of diagnosis and treatment is increasing. However, the disease is difficult to intervene in early stage as early monitoring means are limited. Aiming to find an effective biomarker of PD, this work extracted correlation between each pair of electroencephalogram (EEG) channels for each frequency band using weighted symbolic mutual information and k-means clustering. The results showed that State1 of Beta frequency band (P = 0.034) and State5 of Gamma frequency band (P = 0.010) could be used to differentiate health controls and off-medication Parkinson’s disease patients. These findings indicated that there were significant differences in the resting channel-wise correlation states between PD patients and healthy subjects. However, no significant differences were found between PD-on and PD-off patients, and between PD-on patients and healthy controls. This may provide a clinical diagnosis reference for Parkinson’s disease.

    Release date:2023-02-24 06:14 Export PDF Favorites Scan
  • Research progress on the relationship of vitamin D and vitamin D receptor gene polymorphism with Parkinson’s disease

    Parkinson’s disease is a common chronic progressive neurodegenerative disease, and its main pathological change is the degeneration and loss of dopaminergic neurons in substantia nigra striatum. Vitamin D receptors are widely distributed in neurons and glial cells, and the normal function of substantia nigra striatum system depends on the level of vitamin D and the normal expression of vitamin D receptors. In recent years, from basic to clinical research, there are some differences in the conclusion of the correlation of vitamin D and its receptor gene polymorphism with Parkinson’s disease. This paper aims to review the research on the correlation of vitamin D and vitamin D receptor gene polymorphism with Parkinson’s disease, and discuss the future research direction in this field.

    Release date:2023-05-23 03:05 Export PDF Favorites Scan
  • 经颅磁刺激在帕金森病患者步态异常中的应用

    经颅磁刺激(TMS)是利用变化的高毫安电流产生变化的磁场诱导的感应电场作用于颅内可兴奋组织的过程。TMS以其可进行深部刺激、无痛、非介入等优点,被广泛地应用于帕金森病的研究和治疗中。目前帕金森病患者步态异常发生的病理生理机制尚不清楚,且治疗十分困难。近年来TMS在对帕金森病患者步态异常的研究中得到了较大的进展。现对TMS原理以及在帕金森病患者步态异常研究及治疗中的应用和进展进行综述。

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  • Visual field analysis in early mild Parkinson's disease

    ObjectiveTo evaluate visual field changes in early mild Parkinson's disease. Methods A total of 66 eyes of 33 cases with early mild Parkinson's disease and 72 eyes of 36 age-matched normal individuals were enrolled into the study. Humphrey Field Analyzer II was applied for central visual field test. The visual field indices of mean deviation (MD) and pattern standard deviation (PSD) were analyzed to evaluate the location and the characteristics of visual field defect in this study. ResultsVisual field indices MD (-3.4±2.5) dB was significantly changed in patients with PD when compared to the controls (-0.6±1.7) dB. PSD (4.3±2.6) was significantly higher in patients with PD than that in the control group (2.1±1.8) dB. Glaucoma hemifield test (GHT) assessment was within normal limits in the controls. Of the 33 patients (66 eyes) in PD, GHT showed outside normal limits in 31 eyes, borderline in 8 eyes, and within normal limits in 27 eyes. 31 eyes outside normal limits appeared glaucomatous visual field defects, in which 16 with nasal step and 5 with arcuate defect. ConclusionsVisual field indices including MD and PSD in early mild patients with PD were significantly worse than that in the controls group. GHT abnormalities could be found in early mild PD patients with visual field defects, including pericentral scotoma and nasal step, which mimicked glaucomatous changes.

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  • Changes of retinal nerve fiber layer thickness and its correlation with visual field mean defects in early Parkinson′s disease

      Objective To observe the changes of retinal nerve fiber layer (RNFL) thickness and its correlation with visual field mean defects(MD)in Parkinsonprime;s disease (PD).Methods Fifteen eyes of 15 PD patients in early stage and 18 eyes of 18 normal controls undertook RNFL examination by Stratus OCT3. Circular scans (diameter is 3.46 mm) were taken around the optic nerve head including eight quadrants (superior, inferior, temporal, nasal, temporalsuperior, temporalinferior, nasalsuperior and nasalinferior). The RNFL thickness in different quadrants in the two groups was analyzed. The visual field of PD patients was measured by central 302 program of Humphery750 visual field analyzer, and the MD was recorded. The correlation between RNFL thickness and MD was analyzed by linear correlation and regression analysis.Results RNFL thicknesses of superior, inferior, temporal, nasal, temporalsuperior, temporalinferior, nasalsuperior, nasalinferior and average RNFL thickness in the control group were (132.7plusmn;17.4), (141.5plusmn;15.3) ,(83.2plusmn;17.5), (83.7plusmn;22.3) ,(120.8plusmn;21.2), (117.9plusmn;24.5) ,(109.6plusmn;20.6),(110.2plusmn;27.7), and(109.9plusmn;8.5)mu;m respectively, while in the PD group they were (128.1plusmn;25.3) , (128.6plusmn;13.2) , (68.7plusmn;13.5) , (76.5plusmn;17.8) ,(102.6plusmn;23.7), (103.3plusmn;14.1) ,(101.2plusmn;20.9),(96.6plusmn;15.0),(102.3plusmn;11.9) mu;m. Compared with each other, the differences of RNFL thickness of inferior, temporal, temporalsuperior, temporalinferior and average RNFL thickness were statistically significant(t=2.595,2.700,2.330,2.153,2.131;P=0.014,0.011,0.026,0.040,0.041). There was a close negative relationship between average RNFL thickness and MD in PD patients (r=-0.933,P<0.0001). Conclusions RNFL thickness was significantly thinner in PD patients than that in the normal controls. There was a negative relationship between RNFL thickness and MD in PD patients.

    Release date:2016-09-02 05:41 Export PDF Favorites Scan
  • 帕金森病脑铁沉积的影像学研究进展

    近年来脑铁异常沉积作为帕金森病(Parkinson disease,PD)发病机制之一受到广泛关注。应用影像学技术,尤其是 MRI 技术,对 PD 的脑结构和功能影像的研究报道较多。其中,尤以针对 PD 脑铁沉积的研究众多,但目前脑铁在 PD 中的异常沉积的影像学研究的结论不一致,且脑铁异常沉积在早期诊断 PD 中是否具有应用价值仍有争议。该文就目前 PD 中脑铁沉积的影像学研究及脑铁沉积与 PD 临床相关性研究进行了综述。

    Release date:2017-01-18 08:50 Export PDF Favorites Scan
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