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Comparative Ultrasonography with Radionuclide Imaging Evaluating Parotid of Sjogren Syndrome

摘要:目的:探讨超声与核素显像在评价干燥综合征(SS)腮腺受累情况中的价值和作用。方法:对65例SS病人分别进行超声和核素显像检查。结果:超声判为腮腺功能0级、I级、ⅡⅢ级、Ⅳ级的能力与核素显像判为正常(χ2=0.075,Pgt;0.05)、轻度(χ2=0.12,Pgt;0.05)、中度(χ2=0.27,Pgt;0.05)、重度(χ2=0.097,Pgt;0.05)受损的能力一致,差异无统计学意义;核素发现单纯摄取功能受损的超声多表现为不均匀型、单纯排泌功能受损的超声多表现为结节型、摄取和排泌功能均受损的超声多表现为纤维化型。结论:超声检查可作为SS患者腮腺受累情况评价的良好手段。Abstract: Objective: To quantitatively evaluate ultrasonography and radionuclide imaging in thediagnosis of parotid gland involvement in Sjogren syndrome (SS). Methods: Ultrasonography and radionuclide imaging were conducted on 65 cases with primary Sjogren syndrome. Results: There was no significant difference statistically between the ultrasonographic appearance of the parotid gland and radionuclide imaging (P gt;0. 05). Conclusion: As for diagnosis and evaluating the parotid gland of Sjogren syndrome, ultrasonography may be the useful choice.

The Clinical Efficacy of Total Glucosides of Peony in the Treatment of Primary Sjögren’s Syndrome

目的　观察白芍总苷治疗原发性干燥综合征的疗效及不良反应。 方法　收集2008年1月－2012年1月诊断的原发性干燥综合征患者48例，使其口服白芍总苷0.3～0.6 g，3次/d，疗程6个月，对比治疗前后患者的临床症状及唾液腺功能（唾液腺核素显像定量分析）改善情况、泪液分泌试验（Schirmer试验）、血沉、C反应蛋白、血清γ球蛋白（采用琼脂糖凝胶电泳法）的改善情况，并记录可能的不良反应。 结果　经过6个月的治疗，患者的临床症状、血沉、C反应蛋白、血清γ球蛋白等方面情况有所改善，差异有统计学意义（P＜0.05）。但唾液腺功能、Schirmer试验改善不明显，差异无统计学意义（P＞0.05）。 结论　白芍总苷在改善原发性干燥综合征临床症状及实验室指标疗效好，不良反应少，但在改善唾液腺功能及泪腺功能疗效欠佳。

视神经脊髓炎谱系疾病合并重症肌无力、干燥综合征及桥本甲状腺炎首例报告

Clinical Review of 17 Primary Biliary Cirrhosis

目的：分析原发性胆汁性肝硬化(PBC)患者的临床特征,以提高对该病诊治的认识。方法：分析17例PBC患者的一般资料、临床表现、生化指标、免疫学指标及病理学改变。结果：PBC主要累及中年女性，易合并干燥综合征（SS）。胆管酶升高及抗线粒体M2抗体阳性有助于本病诊断。治疗首选熊去氧胆酸，糖皮质激素、免疫抑制剂适用于合并SS者。结论：早期诊断、早期治疗PBC是防止发展为终末期肝硬化的关键。

干燥综合征患者产后血栓性血小板减少性紫癜出现急性心力衰竭一例

干燥综合征合并视神经炎七例

妊娠合并多因素所致噬血细胞综合征一例

干燥综合征并发脊髓炎一例

干燥综合征误诊为腮腺肿瘤一例

Expression and significance of ERdj5 and XBP1 in primary Sjögren syndrome

Objective To detect the expression levels of ERdj5 and XBP1 in the salivary glands of patients with primary Sjögren syndrome (pSS), and analyze the correlation of the expression levels of ERdj5 and XBP1 with salivary gland damage and oral symptoms to explore their significance in the pathogenesis of pSS. Methods A total of 60 pSS patients in the departments of rheumatology and immunology of Xi’an Honghui Hospital and Qinghai Provincial People’s Hospital between January 2020 and June 2021were randomly selected as the case group, and 20 healthy participants in Qinghai Provincial People’s Hospital in the same period were randomly selected as the control group. The mRNA and protein expression levels of ERdj5 and XBP1 in salivary gland tissues were detected by reverse transcription-polymerase chain reaction and Western blot, respectively, and their correlation with histopathology, salivary flow rate, dry mouth degree, and clinical test indicators were analyzed. Results The mRNA and protein expression levels of ERdj5 and XBP1 in the case group were higher than those in the control group (P<0.001). The ERdj5 mRNA expression was positively correlated with the XBP1 mRNA expression in the case group (rs=0.936, P<0.001). The expression levels of ERdj5 mRNA and XBP1 mRNA in the case group were positively correlated with the pathological grade of labial gland (rs=0.344, P<0.001; rs=0.401, P<0.001), dry mouth degree (rs=0.683, P<0.001; rs=0.730, P<0.001), anti-Ro/SSA antibody (rs=0.363, P<0.001; rs=0.350, P<0.001), anti-La/SSB antibody (rs=0.506, P<0.001; rs=0.471, P<0.001), and European League Against Rheumatism Sjogren’s Syndrome Disease Activity Index (rs=0.782, P<0.001; rs=0.865, P<0.001), and were negatively correlated with salivary flow rate (rs=–0.445, P<0.001; rs=–0.526, P<0.001). Conclusion The expression levels of ERdj5 and XBP1 in salivary glands are increased in pSS patients, and they are related to disease activity, anti-Ro/SSA and anti-La/SSB autoantibodies, damage degree of salivary gland and oral symptoms of patients.