Objective To compare the clinical effects of early enteral and parenteral nutrition, and to study their effects on cytokine release, cellular immune function and protein metabolism in early postoperative patients with gastrointestinal cancer. Methods Thirty-six patients with gastrointestinal cancer were randomly divided into early postoperative enteral nutrition (EN) group (19 cases) and parenteral nutrition (PN) group (17 cases), and they were supported with EN or PN during postoperative period of 1-7 days, respectively. The levels of serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-10 (IL-10) were measured by ELISA. The total lymphocyte count (TLC) and subgroups of lymphocyte (CD3, CD4, CD8, CD4/CD8 and NK cell) were determined with flow cytometer. The urea and creatinine of the 24 h excretory urine were examined at four different phases: preoperative (pre), 1st d, 3rd d and 5th d after operation (pod). The clinical recovery indicators and the complication incidence were also observed. Results All the patients followed the project of nutritional support and relevant examinations, and there was no severe complication and no patient died during the research. The IL-1β, IL-6 and IL-10, the 24 h urea and creatinine increased, while the serum TNF-α and TLC (except 3, 5 pod of EN group) decreased. There was no marked change of the proportion of lymphocyte subgroups after operation and there was no significant difference of the changes of IL-1β, IL-10 and TNF-α between the two groups as well. The levels of IL-6 (3, 5 pod), the 24 h urea (3, 5 pod) and creatinine (3, 5 pod) were significantly lower in EN group than those in PN group （P＜0.05）, whereas TLC (3, 5 pod) were significantly higher than that in EN group （P＜0.05）. In addition, the postoperative infection incidence （10.5% vs 35.3%）, fever duaration, rehabilitation time and medical cost were significantly lower in EN group than those in PN group （P＜0.05）.Conclusion The early postoperative EN has an advantage over PN in the patients with gastrointestinal cancer, which could decrease the release of cytokine and suppress protein metabolism resulting from operational stress, and could reduce the incidence of postoperative infection and inflammatory reaction time. They could also improve the cellular immune function and decrease the rebilitation duration and medical cost.
目的 了解住院患者疼痛控制结局的现状及对疼痛控制的满意度，为疼痛管理提供依据。 方法 2012年5月运用便利抽样法选取206例住院患者为研究对象，采用调查问卷的方式了解患者疼痛管理现状和满意度。调查工具为自行设计的患者基本信息调查表、美国疼痛协会结局问卷修订量表。 结果 调查对象当前、过去24 h内最剧烈的疼痛程度及疼痛平均水平以轻度为主，分别占43.2%、42.2%、40.3%；疼痛对一般活动、情绪和其他康复活动的影响程度以中度为主，分别占52.4%、58.3%、53.4%；对疼痛处理结果的满意度以一般为主，占40.8%；78.6%的患者在入院时未被告知疼痛治疗的重要性；66.5%～84.5%的患者对疼痛和止痛药的认知均较差。 结论 二级医院住院患者的疼痛程度较轻，其对生活影响程度尚不严重，但患者对疼痛控制的满意度欠佳，对疼痛相关知识的认知也较差，急需医护人员采取相应的措施提高疼痛控制的效果和质量，从而提高患者在住院期间的满意度。