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find Author "王如文" 25 results
  • 巨大纵隔肿瘤的外科治疗

    目的回顾性总结28例巨大纵隔肿瘤的诊断要点及外科治疗经验。方法28例巨大纵隔肿瘤患者在全身麻醉双腔气管内插管下行手术治疗,完整切除肿瘤23例,大部分切除5例;同期行肺楔形切除术2例,肺叶切除术1例,部分心包切除术5例,上腔静脉成形术1例。结果无手术死亡患者,术中发生复张性肺水肿2例,失血性休克6例,损伤上腔静脉1例;术后发生心律失常3例,肺部感染4例,经治疗均恢复良好。结论巨大纵隔肿瘤手术治疗效果良好,麻醉时体位及手术切口的选择、术中仔细操作可提高手术的安全性及切除率,预防和治疗术中创面渗血及复张性肺水肿可进一步提高疗效。

    Release date:2016-08-30 06:25 Export PDF Favorites Scan
  • The Prevention of Stricture Formation with Esophageal Intraluminal Stenting in Patients with Corrosive Esophageal Burns

    Objective To introduce the technique of esophageal intraluminal stenting and assess its effect on the prevention of development of stenosis in patients with esophageal burns. Methods Thirty-three patients were admitted less than 3 weeks after ingestion of caustic agents. The second-or third-degree injuries were confirmed by esophogoscopy in all cases, but one with esophageal perforation at admission. Esophageal stenting was performed in all patients and these stents were kept in place for 4 to 6 months. Results There was no death in the series. All patients had a normal intake of food after removal of the stents, and stricture was not found on barium swallow test. Follow-up from 1 to 60 months five cases developed esophageal stenosis from 2 to 3 months after extracting the stents. One of them responded to esophageal bougienage, the remaining 4 patients required esophageal reconstruction and took a normal diet postoperatively. The other 28 patients have a normal diet after the stent removal. Conclusion The esophageal intraluminal stenting is able to prevent the formation of stricture in the aftermath of esophageal burns and its effect will be enhanced plus administering isoniazid.

    Release date:2016-08-30 06:25 Export PDF Favorites Scan
  • 胸腺瘤表皮生长因子受体、增殖细胞核抗原、Bcl-2和Bax表达及临床意义

    目的 探讨胸腺瘤表皮生长因子受体(EGFR)、增殖细胞核抗原(PCNA)、Bcl-2和Bax的表达与胸腺瘤临床病理特征的关系及临床意义. 方法 应用免疫组织化学链霉素亲生物蛋白-过氧化酶(S-P)法检测46例胸腺瘤患者EGFR、PCNA、Bcl-2和Bax的表达. 结果 胸腺瘤EGFR阳性表达率为71.7%,PCNA标记指数为4.00%±1.87%,Bcl-2、Bax阳性率分别为41.3%、15.2%.EGFR表达与胸腺瘤Masaoka分期、肿瘤性质有明显关系,EGFR阴性者术后生存率显著高于阳性者(P=0.005).PCNA标记指数和Bcl-2与胸腺瘤肿瘤性质有明显关系,Bcl-2阴性者术后生存率显著高于阳性者(P=0.002).EGFR、PCNA、Bcl-2和Bax表达均与胸腺瘤组织学类型、是否合并重症肌无力无明显关系. 结论 EGFR与胸腺瘤的发生、发展有关,可作为Masaoka分期的补充推测预后.Bcl-2与胸腺癌发生有关,可作为胸腺癌的标记物用于鉴别诊断.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • Early radiological diagnostic value of closed chest trauma in rabbits

    Objective To explore the early diagnostic value of single photon emission computed tomography(SPECT), thoracic computed tomography(CT),and chest X-ray for closed chest trauma. Methods To establish the animal model of unilateral chest impact trauma,to adopt SPECT, thoracic CT, and chest X-ray for early diagnosis of closed chest trauma,and to compare these findings with postmortem examination. Results Thirty minutes after blunt chest trauma, the region of interesting (ROI) between traumatized lung and the heart (ROI2/ROI1) immediately increased to the peak six hours after trauma; on the contralateral lung, the ratio (ROI3/ROI1) increased slowly and reached the peak after six hours, these ratio was still smaller than that of the traumatized lung. These differences were significant (Plt;0.01). Conclusions Chest X-ray is still the most fundamental diagnostic method of chest trauma,but it was thought that the patients of severe chest trauma and multiple injuries should be examined early by thoracic CT. Radionuclide imaging have more diagnostic value than chest X-ray on pulmonary contusion. The diagnostic sensibility to pulmonary contusion of thoracic CT is superior to conventional radiograph,but thoracic CT is inferior to SPECT on exploring exudation and edema of pulmonary contusion. Thoracic CT is superior to conventional radiograph on diagnosis of chest trauma,therefore patients of severe chest trauma and multiple injuries should be adopted to thoracic CT examination at emergency room in order to be diagnosed as soon as possible.

    Release date:2016-08-30 06:28 Export PDF Favorites Scan
  • Analysis of Postoperative Complications and Cause of Death for Carcinoma of Esophagus

    Objective To analyse postoperative complications and cause of death for carcinoma of esophagus. Methods A retrospective study was undertaken for data of 2 085 patients with esophageal carcinoma from 1963 to 2003, the patients were divided into group A (332 cases,1963-1983), group B(727 cases,1984-1993) and group C (1 026 cases,1994-2003) by time. The postoperative complications and cause of death were analysed. Results Resectability rate, incidence rate of postoperative complications and hospital mortality were 90.84%(1 894/2 085), 11.61% (242/2 085) and 1.82% (38/2 085) respectively. Main complications were pulmonary complications (3.93%,82/2 085),anastomotic leak (3.12%,59/1 894), and cardiovascular disease (1.29%,27/2 085). Resectability rate of group B and group C were higher than that of group A, incidence rate of postoperative complications and hospital mortality of group B and group C were lower than that of group A. Resectability rate of group C were higher than that of group B, incidence rate of postoperative complications except pulmonary complications and hospital mortality of group C were lower than those of group B. Conclusions Pulmonary complications and anastomotic leak are main postoperative complications and cause of hospital death for carcinoma of esophagus, they are decreasing in recent years because of the progress of anesthetic,surgical technique and perioperative management.

    Release date:2016-08-30 06:25 Export PDF Favorites Scan
  • 颈阔肌皮瓣在食管腔内病理变化与修复重建颈段食管的临床应用

    目的 观察颈阔肌皮瓣修复颈段食管后在食管腔内的病理变化及修复重建颈段食管的临床疗效.方法 建立颈阔肌皮瓣修复颈段食管缺损的家犬模型12只,定期活杀取材,对颈阔肌皮瓣和肌皮瓣食管吻合部进行大体、光学显微镜、电子显微镜和免疫组织化学观察.测定颈阔肌皮瓣食管吻合部的抗张强度(WBS)、Ⅰ型前胶原(PCⅠ)及Ⅲ型前胶原(PCⅢ)含量的变化.随访临床应用颈阔肌皮瓣的33例患者,评价其临床疗效.结果 颈阔肌皮瓣在食管腔内仍有毛发生长,上皮保持角化,肌皮瓣上皮有"皮肤型"角蛋白表达,无"食管型"角蛋白表达.术后1个月内肌皮瓣食管吻合部的愈合比皮肤伤口延迟7~14天,术后6个月肌皮瓣食管吻合部有疤痕增生.肌皮瓣食管吻合部碱性成纤维细胞生长因子和转化生长因子β1开始表达的时间较正常皮肤伤口晚,表达的强度减弱,表达的持续时间延长.肌皮瓣食管吻合部WBS和PCⅠ含量在1个月内明显低于皮肤伤口,术后3个月无明显差异,术后6个月PCⅠ含量明显高于皮肤伤口和正常皮肤,PCⅢ含量达最大值的时间比皮肤伤口延迟.肌皮瓣在食管腔内无溃疡、毛发生长和癌变,颈阔肌皮瓣修复重建颈段食管术后患者吞咽功能恢复满意.结论 术后6个月内,颈阔肌皮瓣在食管腔内无明显变化.肌皮瓣食管吻合部早期愈合延迟、后期疤痕增生可能是肌皮瓣修复重建食管后吻合口瘘和狭窄发生率高的重要原因.颈阔肌皮瓣是修复重建颈段食管的较好方法之一.

    Release date:2016-08-30 06:35 Export PDF Favorites Scan
  • Progress of Perioperative Management for Esophagectomy

    Abstract: Due to complicated procedures and severe trauma, esophagectomy still remains an operation with high mortality and morbidity. With the advancement of anesthetic and surgical technique, as well as perioperative management, the mortality and morbidity after esophagectomy decreased significantly in recent years. The optimal perioperative management, normalized and individualized treatment was of importance in preventing postoperative complications and decreasing mortality after esophagectomy. This review summarizes the current state of perioperative management for esophagectomy.

    Release date:2016-08-30 06:01 Export PDF Favorites Scan
  • 外科手术取食管异物15例

    目的探讨外科手术取食管异物的适应证及手术方法。方法采用外科手术摘除尖锐食管异物15例,其中颈段5例,胸段10例。5例颈段异物均合并脓肿,行脓肿切开引流同时取出异物;4例胸段异物摘除后施行改良食管腔内置管术;余6例取出异物后分层缝合食管切口。结果全组无死亡。4例施行食管腔内置管,术后1~2周中毒症状缓解,3~5周拔管后食管X线钡餐造影检查无穿孔或狭窄。1例切开食管取异物后发生右侧脓胸,术后第8d行脓胸廓清术及改良食管腔内置管,1个月后治愈;其余患者术后7~10d恢复经口进食。结论已穿透食管的金属异物和食管镜摘除易引起穿孔的尖锐异物应采用外科手术治疗,改良食管腔内置管对纵隔感染严重、无法修补的穿孔愈合是有帮助的。

    Release date:2016-08-30 06:22 Export PDF Favorites Scan
  • Analysis of thymectomy for myasthenia gravis in 236 patients

    Objective To summarize experiences of surgical treatment and long-term results of myasthenia gravis (MG). Methods Two hundred thirty-six patients underwent thymectomy for MG in our department from Jan.1978 to Dec. 2002. The perioperative management, relative factors of postoperative crisis and long-term results were analysed. Results In 236 patients postoperative crisis took place in 44 cases accounted for 18.6%. The occurrence of postoperative crisis was related to preoperative management, modified Osserman clinical classification and combination with thymoma. Three cases died in the postoperative periods. Among them, one died of acute respiratory distress syndrome induced by aspiration and the other died of crisis. The effective rate in 1, 3, 5 years was 84.6%, 91.0% and 89.0% respectively. Conclusions Thymectomy for MG is safe and effective. Delayed extubation could decrease the needs of tracheotomy in patients with high risk factors for postoperative crisis. The partial sternotomy approach is less traumatic but the long-term effects of surgery are identical to those reported by the most authors.

    Release date:2016-08-30 06:27 Export PDF Favorites Scan
  • Lobectomy for Pulmonary Diseases by Complete Videoassisted Thoracoscopic Surgery

    Objective To investigate the feasibility, curative effect and perioperative treatments of lobectomy for pulmonary diseases by complete videoassisted thoracoscopic surgery (VATS). Methods Fiftysix patients of pulmonary diseases were treated with thoracoscopic lobectomy (including mediastinal and hilar lymph node dissection for malignant diseases) from March 2006 to November 2007 in our Department. Twelve right upper lobectomy, three right middle lobectomy, fifteen right lower lobectomy, nine left upper lobectomy, fourteen left lower lobectomy and three bilobectomy were carried out. The bilobectomy included one right upper and middle lobectomy, two right middle and lower lobectomy. Mediastinal and hilar lymph node dissection was simultaneously performed in the malignant cases. The feasibility, safety and postoperative complications were retrospectively analyzed. Results Fiftytwo patients (92.8%) were performed successfully by complete VATS. The median operative duration and blood loss were respectively 107±29min(from 45min to 168min) and 121±32 ml(from 50ml to 310ml). The incision in two cases (3.6%) were elongated to around 8 cm, the ribs were retracted, and the operations were completed by the help of VATS. Another two patients (3.6%) were changed to conventional thoracotomy for pneumonectomy or hemostasis. The postoperative pathology diagnosis was lung cancer in thirty nine, tuberculoma in seven, inflammatory pseudotumor in four, indurative angioma in four, bronchiectasis in one and metastasic chondrosarcoma in one. There was no surgical mortality. One case suffered from atelectasis in the middle lobe postoperatively and was cured by phlegm suction with bronchoscopy. Two air leakage healed automatically in three days. No other severe complications was observed. The average postoperative hospitalization was 8.9±3.1 d(from 8 d to 14 d). Conclusion Lobectomy for pulmonary diseases by complete VATS is technically fieasible, safe, minimally invasive with less complications and fast rehabilitation.

    Release date:2016-08-30 06:08 Export PDF Favorites Scan
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