Objective To assess the prevalence of malnutrition in patients with advanced non-small cell lung cancer (NSCLC) using the Global Leadership Initiative on Malnutrition (GLIM) criteria, analyze its associated factors, and explore the adverse effects of malnutrition on advanced NSCLC patients in multiple aspects. Methods Patients with NSCLC who were hospitalized for the first time in the Department of Oncology, Shangjin Hospital, West China Hospital, Sichuan University between January and December 2021 were retrospectively selected as the study objects. Malnutrition assessment was carried out in all patients according to GLIM criteria, and the current situation and related factors of malnutrition were analyzed. The Barthel index scale was used to compare the daily activity ability between the malnourished group and the non-malnourished group, the Quality-of-Life Questionnaire-Core 30 scale was used to compare the quality of life between the two groups, and the adverse reactions of the two groups were compared by the hospital information system course records. Results According to GLIM diagnostic criteria, 134 of 285 patients (47.0%) were diagnosed with malnutrition. The results of binary multiple logistic regression analysis showed that age [60-69 vs. <60 years old: odds ratio (OR)=2.323, 95% confidence interval (CI) (1.277, 4.397); ≥70 vs. <60 years old: OR=10.816, 95%CI (4.185, 27.959)], previous medical history [OR=2.740, 95%CI (1.313, 5.717)], and albumin level [OR=0.905, 95%CI (0.848, 0.965)] were associated with malnutrition in patients with advanced NSCLC (P<0.05). The daily activity ability and quality of life in the malnourished group were significantly worse than those in the non-malnourished group (87.57±12.48 vs. 91.82±6.77, P<0.05; 76.22±11.52 vs. 83.96±9.75, P<0.05), and the incidence of adverse reactions in the malnourished group was higher than that of the non-malnourished group (50.7% vs. 31.8%, P<0.05). Conclusions The prevalence of malnutrition in patients with advanced NSCLC is high, and advanced age, previous medical history and albumin are related factors of malnutrition in patients with advanced NSCLC. Combined malnutrition may have adverse effects on mobility, quality of life and adverse effects of anti-tumor therapy in advanced NSCLC patients.
One thousand four hundred and twenty four patients with breast cancer were treated in our hospital from 1980 to 1993. The authors analysed the clinical date of this patients. The results showed that 1193 patients (84.4%) had menopause after 45 years old, 840 patients (59.4%) had menorrhea more than 30 years, 980 patients (80.5 %) had their first pregnancy after 25 years old, and 912 cases (74.9 %) had no history of breast feed. Breast cancer is related to genetic factors, other breast disease, mental factors and trace elements in human hair. The study of breast cancer and its relative factors can be expected to open a new road for the treatment and prevention of this disease.
目的 探讨影响岩斜区脑膜瘤（PCM）预后的相关因素。 方法 回顾分析解放军452医院2005年9月－2009年6月及四川大学华西医院1999年9月－2009年2月110例患者的临床资料及随访结果，通过单因素生存分析及Cox比例风险模型分析探讨影响PCM预后的相关因素。 结果 单因素生存分析发现8种相关因素影响PCM患者的预后，但Cox多因素分析仅发现脑干T2像高信号（OR=5.54，P=0.012）、肿瘤侵入脑干（OR=5.10，P=0.034）、病理高级别（OR=4.03，P=0.011）这3种因素有统计学意义。 结论 脑干T2像高信号、肿瘤侵入脑干、病理高级别可影响岩斜区脑膜瘤患者的预后。
目的 探讨急性阑尾炎手术后切口感染的相关因素。方法 观察我院2002年5月至2007年5月期间收治的665例急性阑尾炎患者采用术前预防使用抗生素、术中保护切口、术后加强切口管理等处理后切口感染情况，并分析切口感染与阑尾炎的病程、手术时间、切口选择、留置引流和病理类型之间的关系。结果 本组患者中32例发生切口感染，感染率为4.81% (32/665)，急性阑尾炎术后切口感染与性别无关（ P ＞ 0.05），与病程长短、切口选择、手术时间、腹腔留置引流与否以及病理类型均有关（ P ＜ 0.01）。结论 病程长、手术时间久、炎症较重的急性阑尾炎病例切口感染率较高； 做好围手术期的处理，术中尽量保护切口可以降低切口感染率。
ObjectiveTo investigate the association between colorectal adenoma (CRA) and colorectal cancer (CRC), and to analyze the main pathogenesis of CRA, in order to identify and control the key factors of CRA and reduce the incidence of CRC. MethodThe studies on the mechanism of CRA in recent years were searched and summarized, focusing on the interaction of inflammation, genetic and epigenetic changes, gut microbiota and lipid metabolism, and their effects on the development of CRA. ResultsInflammation, genetic and epigenetic changes, intestinal flora and lipid metabolism play an important roles in the occurrence and development of CRA. These factors had a significant impact on the formation and progress of CRA at different stages through complex interaction, and had potential application value in preventing CRC. ConclusionsMany factors participate in the occurrence and development of CRA and plays an important role, which provide reference for future research and clinical intervention.
Objective To identify related factors of anxiety and depression in spinal cord injury (SCI) patients based on patient-environment-occupation (PEO) model, and provide evidences for clinical practice. Methods A total of 241 patients with SCI treated between April 2014 and April 2015 were collected as the study subjects. All the patients were confirmed with SCI through CT or MRI, and had physical dysfunction. Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were applied in all the 241 SCI patients to measure their psychological state. Meanwhile, PEO factors such as demographic information as well as ability of activities of daily living (ADL) and relatives’ stress were assessed by self-made questionnaire, Modified Barthel Index (MBI) and Relatives’ Stress Scale (RSS). Then, multiple stepwise regression was applied to identify significant covariance with SAS/SDS as dependent variables and other 14 factors as independent variables. Results The regression equation showed that only SDS, MBI, living environment and disease course were significantly associated with SAS. Only SAS, MBI and RSS were significantly associated with SDS. Conclusions The ability of ADL and environment are significantly correlated with psychological state of SCI patients. Early intervention of ADL and decreasing environmental barriers are needed to improve patients’ psychological state.
【摘要】 目的 探讨内江市企事业及机关单位从业人员20~60岁人群中超重、肥胖者及其相关因素。 方法 2009年6月－2010年9月采用整体随机分层方法，对内江市企事业及机关单位从业人员共5 832例进行调查。用问卷了解吸烟、饮酒、运动、家族史、文化程度，并测定身高、体重、空腹血糖、甘油三酯、胆固醇等。采用SPSS 17.0软件进行统计学分析，以双侧Plt;0.05为有统计学的意义。与肥胖有关的危险因素采用多因素logistic回归分析。 结果 超重及肥胖者比例为27.16%，其中超重者1 377例，占23.6%，肥胖者207例，占3.55%；肥胖较超重者空腹血糖、甘油三酯、血压更高；多因素logistic回归分析提示:超重及肥胖与年龄、吸烟、性别、运动、家族史、文化程度有关，与饮酒无关。 结论 内江市企事业及机关单位从业人员20~60岁人群中超重、肥胖者比例为27.16%；肥胖较超重者更易发生高血糖、高血压、高血脂、高尿酸血症；超重及肥胖与年龄、吸烟、性别、运动、家族史、文化程度均有关。【Abstract】 Objective To investigate the prevalence and the risk factors of overweight and obesity among employees aged 20 to 60 years old in enterprises and government institutions in Neijiang city. Methods From June 2009 to September 2010, 5 832 employees in government departments, enterprises and institutions in Neijiang were surveyed using stratified random sampling method. Items like physical exercise, smoking, drinking, educational level, and family history were collected through face-to-face questionnaire, and their height, weight, fasting plasma glucose, triglyceride, cholesterol were measured. SPSS 17.0 was used for statistical analysis, and the relationship of each index was analyzed by Pearson correlative analysis. Bilateral Plt;0.05 was considered to be statistically significant. Risk factors associated with obesity were analyzed by Logistic regression analysis. Results The overweight and obesity morbidity rate was 27.16%, including 1377 cases of overweight (23.6%) and 207 cases of obesity (3.55%). Fasting plasma glucose, triglyceride, and blood pressure of obesity patients were higher than those of the overweight patients. Correlation analysis showed that overweight and obesity were positively correlated with fasting plasma glucose (r=0.116,Plt;0.01), triglyceride(r=0.319,Plt;0.01), uric acid (r=0.373,Plt;0.01), diastolic blood pressure (r=0.198,Plt;0.01), and systolic blood pressure (r=0.212,Plt;0.01), but not correlated with cholesterol. Logistic regression multivariate analysis showed that overweight and obesity were related with age, smoking, sex, sports, the educational level and family history, but not related with drinking. Conclusions The prevalence of overweight and obesity among employees aged 20 to 60 years old in enterprises and government institutions in Neijiang city is 27.16%. People with overweight and obesity are more susceptible to hyperglycemia, hypertension, hyperlipemia, and hyperuricemia. Overweight and obesity were closely related with age, smoking, gender, sports activities, family history, and educational level.
目的:探索上消化道出血患者焦虑发生情况和相关因素分析。方法:采用问卷调查法对70 例上消化道出血患者发生情况进行研究,分析焦虑发生与患者性别、年龄、文化程度、医疗费用支付方式、出血次数、临床症状、疾病了解程度及合并疾病的相关性。结果:上消化道出血患者焦虑发生率为58.6 %。女性患者焦虑发生率明显高于男性患者,出血量多的患者焦虑发生率明显高于出血量少的患者,出血次数、有无合并症与焦虑有明显相关性。结论:正确认识焦虑是开展负性情绪干预的前提,针对上消化道出血患者焦虑发生相关因素,积极开展心理疏导,是保障手术顺利进行的重要环节。