PURPOSE:Investigating on histopathologic changes of the photoreceptors in retinitis pigmentosa. METHODS:Observation of the photoreceptors of retinitis pigmentosa in 11 eyes among 9 cases using light and electron microscope. RESULTS: The pathologic changes of the photoreceptors were found to be mostly marded at the equatorial area and less at the periphery,posterior pole and macular region of the retina. In relatively early cases,degeneration and shortening of outer segments,reduction or loss of connecting cilia,stubby inner segments and swollen mitochondria Were the predominant findings. In advanced cases,the inner and outer segments and connecting cilia were diminished with reduction of nuclei in number and disarangement,cellular degeneration and disorganization. The outer limiting membrane adhered to RPE or Bruch membrane. The spaces left over by the above pathologic changes were replaced by the displaced Muuml;ller cells and their hypertrophic processes. Also there were degeneration of the RPE cells,and some of them might migrate into the retina. CONCLUSION:Obvious invasions of pathologic processes in photoreceptors of the retina did present in patients with retinitis pigmentosa. （Chin J Ocul Fundus Dis,1996,12:160-162）
Objective To probe the clinical character,the histopathological classification and misdiagnoses of intraocular tumors. Methods The clinical and pathological data of 359 patients with intraocular tumor diagnosed clinically between 1980～2000 were retrospectively analyzed. Results There were 300 cases of malignant tumor and 23 cases of benign tumor respectively. Non-oncologic malady and benign tumor misdiagnosed as tumor or malignant tumor were 40 cases. The two leading malignant tumors were retinoblastoma and melanoma. Conclusion The clinical and pathological analysis of intraocular tumor is beneficial to the correct clinical diagnosis and treatment. (Chin J Ocul Fundus Dis,2002,18:28-30)