ObjectiveTo study and analyse the correlation between biologic behavior and clinical factors in gastric cancer.MethodsClinical and pathological study of carcinoma of stomach were retrospectively made in 1034 patients. ResultsIn this series,148 of 1034 patients (14.3%) were early gastric cancer.The frequency of lymph nodes metastasis was higher in proximal gastric cancer than distal (P＜0.0001).Similar frequency can also be seen in the tumor of larger diameter (P＜0.01),deeper invasion (P＜0.0001) and poor differentiation (P=0.004).Some difference in ages and sex of patients may be found on the invasion (P=0.003),differentiation (P＜0.0001),site (P＜0.001) and frequency of lymph nodes metastasis of the tumor (P=0.01).In multifactorial multivariate linear regression analysis,the site of tumor (P=0.003),diameter of tumor (P＜0.0001),depth of tumor infiltration (P＜0.0001) and the cell differentiation showed significant association with lymph node metastasis,in which the female patient had more lymph node metastasis than male (P＜0.001).Depth of tumor infiltration was the most important factor in lymph node metastasis.Numbers of lymph nodes resected were much more in total and distal gastrectomies than that in proximal gastrectomy (P＜0.0001). ConclusionThe results of this study suggest that radical gastrectomy with lymphadenectomy is necessary even in all stages of gastric cancer.
目的探讨Billroth-Ⅱ胃大部切除术后输入袢梗阻的诊断和手术方式。 方法本组共17例输入袢梗阻患者，对17例患者的手术史、临床表现及影像学资料进行总结分析。 结果典型的输入袢梗阻表现为上腹胀痛、上腹部触及张力较高且有压痛的囊性包块，腹部CT检查见腹主动脉与肠系膜上动脉之间横向走行的扩张肠管。17例患者均再次行剖腹探查术，术中见输入袢扩张，5例行Braun吻合术，12例行Roux-en-Y吻合术。术后无严重合并症，无围手术期死亡，患者均恢复顺利，梗阻症状消失。术后随访1～4年（平均2.5年），经X线胃肠钡餐检查见吻合口钡剂通过顺利，无狭窄；胃镜检查未见胆汁反流。 结论严格遵守正确的手术操作常规是预防输入袢梗阻的关键；经腹部CT诊断明确后，应尽早再手术；Braun吻合术及Roux-en-Y吻合术为胃大部切除术后输入袢梗阻较理想的术式。
Objective To evaluate the effect of total gastrectomy (TG) and proximal gastrectomy (PG) for the treatment of advanced esophagogastric junction cancer. Methods Clinical data of 273 cases of advanced esophagogastric junction cancer who underwent TG and PG in our hospital from Jan. 2004 to Dec. 2010 were reviewed for retrospective analysis. Operation related indexes, 3-year cumulative survival rate, and 5-year cumulative survival rate were compared and evaluated. Results There was no significant difference between TG group and PG group in intraoperative blood loss, operation time, and hospital stay(P > 0.05), but the number of dissected lymph nodes in TG group was obviously more than those of PG group, and the difference was statistically significant(P=0.000). The postoperative complication rates were 10.3%(12/117)in TG group and 21.8%(34/156) in PG group respectively, which was lower in TG group(χ2=6.353, P < 0.05). The 3-year and 5-year cumulative survival rates of TG group were 58.9% and 34.2%, of PG group were 43.4% and 23.6% respectively, and the 3-year and 5-year cumulative survival rates were all lower in PG group(χ2=5.894, P < 0.05;χ2=5.582, P < 0.05). For patients in stage pT4, pN2, and TNMⅢ, whose tumor size were bigger than 3.0 cm, and patients who had accept chemotherapy, the 3-and 5-year cumulative survival rates of TG group were significantly higher than those of PG group(P < 0.05). However, for patients in stage pT2, pT3, pN0, pN1, pN3, TNMⅠ, TNMⅡ, TNMⅣ, whose tumor size were smaller than 3.0 cm, who had not accept chemotherapy, and patients of any pathological type, there was no statistically significant difference between the 2 groups in 3-year and 5-year cumulative survival rates(P > 0.05). Conclusion For the patients who suffered from advanced esophagogastric junction cancer, TG can improve long-term survival rate, and it can significantly reduce the incidence of postoperative complications and improve postoperative quality of life.
目的评价Roux-en-Y胃空肠吻合术在远端胃大部切除消化道重建中的临床价值。 方法对笔者所在医院科室2009年1月至2012年7月期间31例远端胃癌行Roux-en-Y消化道重建患者的临床资料进行回顾性分析。 结果全组病例无围手术期死亡，无吻合口漏、十二指肠残端瘘、输入空肠段梗阻及倾倒综合征发生。28例（90.3%）患者术后半年进食3～4次/d，每餐量150～400 g；血红蛋白110～150 g/L，血清白蛋白38～50 g/L；24例（77.4%）患者体质量恢复或超过术前水平。胃镜检查未发现反流性食管炎，有残胃炎表现者3例，但无临床症状。 结论Roux-en-Y胃空肠吻合术可成为远端胃大部切除消化道重建的主要术式。
ObjectiveTo compare clinical outcome between single-incision laparoscopic subtotal gastrectomy (SILSG) versus laparoscopy-assisted subtotal gastrectomy (LASG) in treatment of benign gastric ulcer and duodenal ulcer. MethodsClinical data of 37 patients with benign gastric ulcer or duodenal ulcer who underwent laparoscopic subtotal gastrectomy between Jan. 2008 and Feb. 2015 at Shengjing Hospital of China Medical University was collected retrospectively. Among them, 15 patients underwent SILSG and 22 patients underwent LASG. Demographic, intraoperative, and postoperative data was analyzed and compared between the 2 groups. ResultsThe operative time of SILSG group was significantly longer than that of LASG group (P < 0.050). However, the postoperative hospital stay was significantly shorter (P < 0.050), and the total patient scar assesment scale (PSAS) score was significantly lower (P < 0.050) in the SILSG group than those of LASG group. There was no significant difference between the 2 groups with respect to other variables (P > 0.050), such as conversion rate, intraoperative blood loss, postoperative exhaust time, incidence of complication, and visual analog scale score of pain. All patients received postoperative follow up, and the period ranged from 6 months to 25 months, with a median of 11 months. During the follow up period, no one suffered from incision hernia and recurrence of ulcer. ConclusionCompared with LASG, SILSG is a technically feasible procedure with better cosmesis and equivalent curability.
目的探讨残胃癌的临床特点和诊治方法。方法对1989~2003年收治的15例残胃癌病例资料进行回顾性分析，观察不同手术方式对预后的影响。结果B-Ⅱ式手术后残胃癌发病率远高于B-Ⅰ式手术； 根治性手术切除8例，根治性切除率为53.3%（8/15）； 根治性手术切除患者2年以上生存率为62.5%（5/8），姑息性手术切除患者术后平均生存时间不足1年。结论早期诊断和根治性切除是残胃癌预后的重要因素。