Objective To investigate the clinical value of " O”continuous biliary-enteric anastomosis combined with percutaneous transhepatic cholangial drainage (PTCD) in pancreaticoduodenectomy (PD). Methods The clinical data of 35 patients with PD who were admitted to Xinyang Central Hospital from June 2015 to June 2017 were retrospectively analyzed. Results All patients completed the " O” continuous biliary-enteric anastomosis combined with PTCD without perioperative death. ① The preoperative indwelling time of PTCD tube was (13.24±3.39) d, total bilirubin (TBIL) was (363.67±12.26) μmol/L on admission and (155.59±17.63) μmol/L on preoperative after PTCD, respectively. ② The operative time was (231.46±18.69) min, the intraoperative blood loss was (158.30±31.33) mL, the diameter of the hepatic ductal segment was (1.3±0.2) cm, and the duration of the " O” continuous biliary-enteric anastomosis was (7.31±1.52) min. ③ After surgery, the indwelling time of PTCD tube was (8.13±1.49) d, the hospitalization time was (27.31±5.49) d. Biliary leakage occurred in 1 case, pancreatic fistula occurred in 5 cases (3 cases of biochemical sputum and 2 cases of B-stage pancreatic fistula), abdominal infection occurred in 2 cases, pneumonia occurred in 3 cases, wound infection occurred in 2 cases. No postoperative biliary-enteric anastomosis stenosis, biliary tract infection, and intra-abdominal hemorrhage occurred. There was no laparotomy patients in this group and all patients were discharged. ④ All patients were followed-up for 180 days after surgery. No death, bile leakage, biliary-enteric anastomotic stenosis, biliary tract infection, pancreatic fistula, gastro-intestinal leakage, and abdominal infection occurred. One case of delayed gastric emptying and 2 cases of alkaline reflux gastritis were cured after outpatient treatment. Conclusions The preoperative PTCD can improve the preoperative liver function and increase the security of PD. " O” continuous biliary-enteric anastomosis is simple, safe, feasible, and has the function of preventing biliary-enteric anastomosis stenosis. For severe jaundice patients with blood TBIL >170 μmol/L, the " O” continuous biliary-enteric anastomosis combined with PTCD is an alternative surgical procedure for PD.
The secondary anastomotic stenosis is often occured from the repair and reconstructive operation of the injured bile duct. It is difficult to treat and the outcome is serious. In order to prevent this complication, the fibrin glue instead of traditional suturing technique combined with inner support was used. Fifty-four hybrid dogs were divided into 3 groups. Group A received Roux-en-y choledochojejunostomy with fibrin glue; group B received Roux-en-y choledochojejunostomy, with a fibrin glue combined support left permanently in the bile duct and group C received Roux-en-y choledocholejejunostomy with fibrin glue combined a support left temporarily in the bile duct. The amount of collagen in the scar was measured at 3/4, 3, 6, 9, 12 months respectively after operation. The results showed: 1. the mature period of scar was shortened from 12 months to 9 months when fibrin glue instead of suture was used in choledochojejunostomy; 2. the mature period of scar was further shortened from 9 months to 6 months when fibrin glue combined with inner support instead of fibrin glue was used in choledochojejunostomy. The conclusions were as follows: 1. fibrin glue could facilitate the healing of wound by inhibiting the formation of scar and accelerrate the maturation of scar; 2. when the inner support was used with fibrin glue in the operation, the mature period of scar could be further shortened; 3. the mechanism of action of the fibrin glue included minimizing the injury, avoiding foreign-body reaction, modifying organization of hematoma, preventing formation of biliary fistular and enhancing intergration and cross-linkage of collagen.
The antireflux spur-valvewas originally designed for the Roux-Y cholenterostomy. It is made by plication of the two upper limbs of the "Y" after the removal of the seromusculature from the biliary limb, so that the conjoined wall-in-between will he compassed deviating to the biliary, side to form a spur value. It could successfully stop the reflux due to normal peristalsis or intestinal distension. This value was primarily used in choledochal cyst and biliary atresia for more than 100 cases, and also applielied to many other operations for perventing reflux, including: gastroesophageal refluk-Nissen fundoplication, colon replacement of esophagus, side to side shert-circuit of intestinal obstruction, and Kock scontinent ileoslomny. The detailed procedures were described.
Objective To investigate the choleenterostomy type and the longterm results in treatment of benign diseases of biliary tract. MethodsA total of 614 cases of choleenterostomy from January 1981 to December 2000 were followed up and analysed. The original diseases: 321 were original hepatolithiasis and/or bileduct stricture (52.3%)， 106 congenital cyst of common bile duct (17.3%), 151 iatrogenic bile duct injury (24.6%) and others 36 cases (5.9%). Choledochoduodenostomy was performed in 89 cases and choledochojejunostomy in 525 cases. Five hundred and twentyfour cases have been followed up for 1 to 20 years. The rate of followup was 87.9%. ResultsIn 84.5% of the cases, excellent or good longterm results were achieved. Reoperation rate were 49.4% in cases of choledochoduodenostomy or cystoduodenostomy, 14.2% in sideside (cyst) cholangiojejunostomy and 4.4% in endside cholangiojejunostomy, respectively. Conclusion The choledochoduodenostomy should be abolished. The endside cholangiojejunostomy shoud be the best choice when it is needed to perform choledochojejunostomy in benign bile duct diseases and can promise a satisfactory longterm result.
Objective To observe the effects of basic fibroblast growth factor (bFGF) on wound healing of bilioenteric anastomosis as to prevent postoperative biliary strictures. Methods A model of choledochodundenostomy in 31 dogs were constructed at first, then bFGF was administered on the local anastomosis(bFGF group) for 1 week after the operation as compared with sodium chloride solution(control group). Both groups were observed with light microscope(HE,Masson staining) and electron microscope 3 days, 1 and 3 weeks and 3 and 6 months after the operation（n＝3）. Hydroxyproline was measured at the same time. Results bFGF group healed more quickly compared with control group. Good function of cells were detected by electron microscope. Better mucosa epithelia, fibroblast,and capillary vessel proliferation were detected by histological observation in bFGF group. In bFGF group, collagen fibers were arranged orderly. Three weeks after operation, collagen fibers in control group were orderless and in whirlpool. Hydroxyproline of bFGF group was lower than that of control group(P＜0.05）.Conclusion bFGF administered in local anastomosis is an effective method to prevent postoperative anastomotic stenosis.
Three types of intestinal loops were used to reestablish the internal drainage of bile in 17 cases. The leeway derived from the peristaltic cycle of the intestinal loop for gastrointestinal reflux pressure, the cholangeitis after operation from reflux following choladocho-intestinal anastomosis could be avoided, and, naturally it had changed the traditional method of purèly blockade of the reflux, thus the result from treatment was far more satisfactory.
目的 探讨实施肠内营养的途径。方法 采用回顾性研究的方法，分析兰州大学第一医院2007年1月1日至2007年12月31日实施胆肠吻合术的15例患者的临床资料，包括复发性胆管结石4例，胆管癌3例，胆总管囊肿3例，壶腹癌（不能根治）5例； 平均年龄75.5岁； 在行胆肠Roux-en-Y吻合时，利用空肠盲襻实施空肠造瘘，术后第12 h开始肠内营养。统计肛门排气时间、住院时间及并发症。结果 15例患者平均肛门排气时间为54.6 h，平均住院时间为12 d，平均营养管拔除时间为20 d； 发生吻合口漏1例，肺部感染1例，切口感染1例，无一例因造瘘而发生机械性肠梗阻。结论 胆肠吻合利用空肠盲襻实施空肠造瘘肠内营养是肠内营养一种方便、可行的途径，它可以减少并发症的发生，缩短患者的住院时间，减轻患者的经济负担。与传统的方法比较，不会引起咽部不适及肺部感染，患者依从性好； 不会导致机械性肠梗阻，安全可行。