Objective The purpose of this study, which focuses on the number of the Cochrane Systematic Review’s (CSR) full texts, protocols and registered titles from Chinese authors, is to show the development of evidence-based medicine (EBM) and promote EBM’s further development in China. Methods On the basis of The Cochrane Library (Issue 1, 2009) and the Cochrane Collaboration (March 2009) periodicals, we performed statistical analysis of different countries that released CSR’s full texts, protocols and registered titles, as well as the time, authors and distribution of the CSR’s full texts, protocols and registered titles in China. Results The publishing rates of the CSR’s full texts, protocols and registered titles in China ranked the seventh, fifth and second, respectively. Although the number of CSR’s full texts and protocols showed an increased annual trend in China, the development of area distribution was unbalanced. Moreover, China’s published articles contained 47 Cochrane collaboration groups, without effective practice and health care groups, consumers and communication groups, and methodology and multiple stenosis groups. Conclusions The current Chinese EBM situation has a great potential in writing CSR. However, there are still many problems that need to be resolved.
Objective To evaluate the efficacy and safety of Salviae miltiorrhizae Injection (include Danshen Injection and Fufang Danshen Injection) for chronic cor pulmonale. Design A systematic review of randomized clinical trials. Method Randomized trials comparing Salviae miltiorrhizae Injection plus routine treatment versus muting treatment alone were identified by electronic and manual searches. No blinding and language limitations were applied. The Jadad scale assessed the methodological quality of trials. Results Thirty randomized trials (n=2 161) were identified. The methodological quality of all trials included was low. The combined results (RR and 95%CI) of symptom scores was 1.20 (1.15 to 1.26). Because of the significant heterogeneity, many other markers of the blood rheology can not be combined. The reason for heterogeneity should include the differences among cases and studies. Because of lacking enough studies, the conclusions about mortality and oxidants/antioxidants markers were not b. Only a few studies had reported adverse events. Conclusions Based in the review, Salviae miltiorrhizae Injection may have positive effect on symptom scores in patients with chronic cor pulmonale. But for mortality, the markers of blood rheology and oxidants/antioxidants, there is no reliable conclusion. However, the evidence is not b due to the general low methodological quality, the variations among studies and experimental markers themselves, and lacking of more relevant and important markers. Further large trials are needed.
Objective To analyze the methodological quality of clinical practice guideline mentioned “evidence-based” in China. Methods We selected clinical guidelines developed based on evidence issued by the Chinese Medical Association in 2010-2012, and meanwhile, we conducted additional search for guidelines on clinical major diseases. Then, we selected literature according to the inclusion and exclusion criteria and evaluated the included guidelines according to 8 items relevant to methodological rigor which were selected from the Appraisal of Guidelines for Research and Evaluation (AGREE II). If the guidelines comply with the item, we recorded 1 point, otherwise 0 point. Results a) Among twenty-two included guidelines, 13 were originated and 9 were updated once every 3 to 5 years. b) Diseases covered stroke, diabetes, chronic hepatitis B, hypertension, pediatric nutrition, etc. c) The number of guideline references were 10 to 218, of which, nine guidelines cited 24 Cochrane systematic reviews (CDSRs), accounted for 2.62% (24/916). Among them, the acute ischemic stroke guideline cited the most (7 CDSRs). d) The number of experts involved in guidelines development was 2 to 95 and guidelines pages were 4 to 150. e) The guidelines’ quality generally scored 4 to 7, most of which described the process of guidelines development. The grades of recommendation were consistent with the levels of evidence. But most of the included guidelines did not clearly described literature research methods, peer reviewer, and update procedures. Conclusion There is a growing trend that clinical guidelines are developed based on evidence in China. However, the quality of reporting and the methodological rigor of guidelines need further improvement. The citation rates of Cochrane systematic reviews in these guidelines were relatively low. We suggest that guideline recommendations should be consistent with the levels of evidence and adapt to local conditions, and relevant support policies for guideline implementation in practice. In future, attention should be paid to the aspects of guideline development methods, reporting standard, guideline accessibility, and standard training for relevant personnel.
Cochrane协作网（www.cochrane.org）是世界上最大的致力于制作、保存和提升卫生保健干预效果系统评价可及性的国际组织。它拥有100多个参与国，主要与负责制作和保存Cochrane系统评价的各Cochrane系统评价组相关。从2000年起，依靠散在各国的各Cochrane系统评价组活跃成员已完成系统评价的定期审核。至2010年初，协作网已从2000年约5 500人增加至近28 000人。Cochrane活动发展迅速，Cochrane系统评价和计划书的作者人数增长尤为突出。2000年，各Cochrane系统评价组有2 840个注册作者。到2010年初，注册作者数已升至21 000人以上。
Objectives To assess the effectiveness and safety of additional bedtime H2-receptor antagonists (H2RAs) in suppressing nocturnal gastric acid breakthrough (NAB). Methods We identified eligible trials by searching The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMbase and CINAHL. We handsearched the data from the proceedings of correlated conferences, eight kinds of important Chinese journals and references of all included trials. All randomized controlled trials evaluating H2RAs for the control of NAB were eligible for inclusion. The systematic review was conducted using methods recommended by The Cochrane Collaboration. Results Only two randomized crossover studies including 32 participants met the inclusion criteria. Because the design, dosage and duration of the treatment were different between the studies, it was impossible to conduct Meta-analysis. There was no consistent conclusion between the two included studies in evaluating H2RAs for the control of NAB. Conclusion We can not conclude any implications for practice at this stage. Appropriately designed large-scale randomized controlled trials with long-term follow-up are needed to decide the effects of additional bedtime H2RAs in suppressing NAB.
This paper reports publication status, authors distribution and the difficulties of producing Cochrane systematic reviews （CSRs） in China to offer new ideas for further development of CSR. in China. Up to Dec. 2005, Chinese authors have published 28 CSRs （1.1%）, 10 of which were indexed by SCI.
Objective To search through the Cochrane database of systematic reviews using the flag new search option to find out whether this strategy helps update revivews. Methods We chose the New search option in the advanced search in The Cochrane Library on Wiley InterScience (Issue 1, 2009), and input all hit citations to the ProCite software. We then looked through the `What’s new`,`History`, as well as `Appendices` on hit reviews in the Cochrane library one by one, and then added these related contents to thef ield of the ProCite in order to analyze the results. Results A total of 140 systematic reviews had the flag new search. Among them, the total new search frequency were 274, meaning frequency was 1.96/1; updated within two years were 58 (41.43); there were 61 reviews with `Appendices` (43.57%). The status of the chosen database among the 61 reviews with `Appendices` was as follows: most were from MEDLINE (56 reviews, 91.80%), next EMBASE (47 reviews, 77.05 %), and finally CENTRAL (45 reviews, 73.7%). Among the reviews with `Appendices`, most of them were not correctly labeled. Conclusion Although some Cochrane systematic reviews are updated in a timely fashion, there is some incomplete information, although it may be still helpful for researchers to look for new studies.
ObjectiveTo investigate the extent of overlap between Chinese systematic reviews (SRs) and Cochrane SRs in the field of stroke. MethodsThe CNKI, WanFang Data, CBM and Cochrane Library databases were searched to collect Chinese SRs and Cochrane SRs in the field of stroke published from 2012 to 2022. By extracting population (P), intervention (I), comparison (C), and outcome (O) of all interventional SRs in the stroke field to analyse the extent of overlap of SRs. The basic information and research information of SRs with overlapping PICOs were further extracted to conduct descriptive analysis. ResultsA total of 1 303 SRs were included, involving 1 192 Chinese SRs and 111 Cochrane SRs in the field of stroke. The overlapping analysis found that 128 Chinese SRs overlapped with 29 (26.1%) of the 111 Cochrane SRs. Most (127/128, 99.2%) Chinese SRs were published later than Cochrane SRs. The year of publication of overlapping SRs showed a trend of increasing year by year. ConclusionThe SR work carried out by scholars in China has the problem of overlapping studies that cannot be ignored, and the lack of strict regulation and guidance in methods such as registration, protocol writing, and literature search has resulted in a great waste of resources. It is necessary to further strengthen regulatory constraints and guidance, adhere to problem orientation and quality awareness, strengthen SR training, and reduce overlapping research.