Objective To evaluate the methodological and reporting qualities of randomize controlled trials involving MTC (microwave tissue coagulation) therapy for cervical erosion. Methods Through computer and handsearch, randomized controlled trials (RCTs) and/or quasi-randomized controlled trials (quasi-RCTs) were collected. The methodological quality of the included studies was assessed using quality assessment criteria of Cochrane systematic review guideline, and the reporting quality was assessed using the CONSORT (Consolidated Standards of Reporting Trials) checklist.Results Eleven clinical controlled trials (CCTs) were included. Three were RCTs and eight were quasi-RCTs. The methodological and reporting qualitiy of the included studies was generally low (10 trials ranked Level C, and the maximum CONSORT score was only 17).Conclusions The quality of the CCTs involving microwave therapy for cervical erosion is generally low with a high risk of biases. And the reporting of these trials is also incomplete. Therefore, more randomized controlled trials of high quality are required to provide reliable evidence.
Purpose To analyze the contents of domestic and inter national public ations in neuro-ophthalmology during the past decade. Methods CBM and Medline were separately searched in 2007, by using Medical subject heading for retrieving Chinese and English language neuro-ophthalmic articles which were published between 1997 and 2006. Results A total of 13052 Englishwritten a rticles available for analysis were contributed from more than 70 countries, mainly from USA, United Kingdom, Japan, Germany, Italy and Canada. The order of frequency was visual cortex（4496/13052，34.4%），optic nerve diseases（3870/13052，29.7%），ocular mo tility disorders（2899/13052,22.2%），visual pathway（1191/13052,9.1%）pupil dis orders(596/13052，5.6%). While a total of 3726 articles were retrieved from CBM, the order of frequency being optic nerve diseases（1854,49.8％），ocular motili ty disorders(excluding strabismus, 1357,36.4%),pupil disorders (242, 6.5%)，visual cortex(202, 5.4%), visual pathway(excluding retina, optic nerve, visual cortex, 71). Researchers with diverse specialties contributed to the neuro-ophthalmic publications. Compared with international counterpart, domestic articles relate d to basic researches were much less. Conclusion Neuro-ophtha lmoloy is interdisc iplinary with a wide range of researches and various study hotspots. Domestic basic researches on neuro-ophthalmology remain to be strengthened and improved. (Chin J Ocul Fundus Dis,2008,24:99-102)
ObjectiveThis study proposes employing large language models (LLMs) for medical literature quality assessment, exploring their potential to establish a standardized and scalable intelligent evaluation framework for off-label drug use (OLDU). MethodsThe study used two freely available LLMs platforms in China, DeepSeek-R1 and Doubao. Following the medical literature quality assessment tools recommended in the evidence-based evaluation specification for off-label drug use issued by the Guangdong Pharmaceutical Association, we selected the Jadad scale and the MINORS criteria. These tools were employed to assess the quality of the two most prevalent types of medical literature in OLDU evidence evaluation: randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs). Utilizing chain-of-thought (CoT) prompting techniques, we developed standardized evaluation templates. The quality scores generated by the LLMs were then compared against those reported in systematic reviews or assigned by clinical pharmacists. ResultsFor RCT, DeepSeek-R1 demonstrated consistency with human assessments in quality appraisal. However, discrepancies exist between the Doubao model and manual evaluation results, with three repeated evaluations yielding inconsistent outcomes and inaccurate identification of "allocation concealment" items. For Non-RCT, all models achieved concordant quality assessment outcomes with human evaluators, while demonstrating unique capacity to detect systematic evaluation inaccuracies attributable to human subjective bias. ConclusionThis study demonstrates that prompt engineering-driven LLMs can efficiently conduct quality assessments of medical literature. However, the selection of models requires rigorous validation against domain-specific benchmarks, alongside mandatory expert validation of scoring outputs. Our findings further reveal the necessity of refining current quality appraisal criteria through granular operational definitions, thereby facilitating standardized automation. This approach not only enhances the efficiency and transparency of evidence-based decision-making for OLDU but also extends to systematic reviews and rapid health technology assessments. By replacing traditional literature quality evaluation models with automated scoring mechanisms, it enables a paradigm shift in the efficiency of evidence processing.
摘要:目的:调查格列本脲的10年来不良反应情况为临床上合理使用格列本脲提供参考。方法:检索近10年(1999~2009)维普中文科技期刊数据库报道的格列本脲的不良反应文献,进行统计、分析。结果:格列本脲不良反应表现较多,机制复杂,最常见的是低血糖,其次是肝功能损伤。结论:临床上应该重视格列本脲的不良反应情况,针对不同病人合理用药。Abstract: Objective: To investigate the adverse reaction of glibenclamide in resent ten years so as to promote rational clinical glibenclamide Use. Methods: The adverse reaction reports in the vipdatabase (19992009) were summarized and investigated. Results:There exist complicated mechanism and lots of clinical symptoms of the adverse reaction of glibenclamide. The most common adverse reaction of glibenclamide is glycopenia. Conclusion: Great attention should be paid to adverse reactions of glibenclamide for rational drug use. Glibenclamide should be used according to physiological and pathological situation of patients.
摘要:目的: 报道同卵双生子间肾移植效果,探讨免疫抑制剂及激素的使用、鉴定同卵双生子的方法以及术后随访。 方法 :个案报道结合文献综述。 结果 :手术获得成功。术后随访8月,患者恢复良好。 结论 :同卵双生间的肾移植安全有效,术后不需要使用免疫抑制剂也能维持移植肾功能正常。Abstract: Objective: Reported the effects of renal transplantation between identical twins,explored the use of immunosuppressive drugs and glucocorticoid, identification method of the identical twins and postoperative followup . Methods :Combining case report and literature review. Results :The operation is success.Followup in 8 months,the patient recover well. Conclusion : The renal transplantation between identical twins is safe and effective,the immunosuppressant is not need for the postoperative patients to maintain the graft`s function.
Objective To assess the quality of reporting of randomized controlled trials (RCTs) related to traditional Chinese medicine (TCM) published in the Chinese Journal of Evidence-Based Medicine by CONSORT statement and Jadad scale. Methods We handsearched the Chinese Journal of Evidence-Based Medicine to identify TCM RCTs. The revised CONSORT statement and Jadad scale combined with self-established criteria were applied. Results A total of 57 RCTs were identified of which there were 17 TCM RCTs. Some items in CONSORT checklist were completely reported in all TCM RCTs, such as abstract, inclusion and exclusion criteria, intervention, randomization sequence generation, description of statistic method, description of baseline data, outcomes and estimation, and explain results. Compared with the previous findings, there were more trials in this study to report allocation concealment, randomization implementation, use of flow chart and appliance. Only 3 RCTs (17.6%) reported acknowledgements. One RCT did not describe syndrome type of TCM, and 4 RCTs (23.5%) carried out dummy. The mean Jadad score was 4.35±1.11 in all trials, of which 11 RCTs (64.7) ranked 5 points. Conclusion The comprehensive quality of reporting of TCM RCTs published in the Chinese Journal of Evidence-Based Medicine from 2001 to 2008 has been improved. After the publication of CONSORT statement and CONSORT for traditional Chinese medicine, the quality of reporting of TCM RCTs is improved. We are looking forward to improving the CONSORT for TCM.
ObjectiveTo investigate the capability and demands of medical students of medical information retrieval, and to provide information for medical information literacy education.MethodsWe conducted an online questionnaire survey among medical students from 15th to 21st July, 2019, aiming to analyze basic characteristics of the subjects and their ways and capability to acquire medical information, and evaluated their demands and satisfaction about relevant courses.ResultsFour hundred and nine valid questionnaires were collected. The average age of the respondents was (21±3) years old. Among the respondents, 279 (68.2%) were female, 290 (70.9%) were undergraduates, and 187 (45.7%) majored in clinical medicine. The mostly accessed ways to obtain medical information were textbooks (87.8%) and search engines (84.4%). Among Chinese literature databases, the most commonly used was China National Knowledge Infrastructure (67.7%), followed by Wanfang (54.3%). As for English literature databases, the most commonly used was PubMed (66.0%), while the proportions of respondents who used other databases was less than 1/4. As for the problems when obtaining information, 84.8% of the respondents supposed that no access to some online databases was the main problem. Obtaining information from search engine scored the highest [(3.21±1.00) points, 5 points totally] when they were asked to self-evaluate their ability to obtain medical information by different methods. In terms of training demands, the need for courses about literature authenticity and accuracy evaluation was the highest [(4.05±1.07) points, 5 points totally]. The trainings were expected to be conducted within 1-2 years after enrollment (83.9%). Training through professional courses (86.8%) was the most welcomed training form, followed by courses on MOOC (51.3%), an online course platform. More than 50% of the respondents were satisfied with the current relevant courses and trainings.ConclusionBoth the students’ capability of medical information retrieval and the design of relevant trainings should be improved to better prepare the medical students for further clinical practice and scientific research.
摘要:目的: 分析特非那定所致不良反应的临床特征、相关因素,为临床药物治疗中药品不良反应的防治提供参考依据。 方法 :检索1986～2008年国内文献源特非那定的不良反应资料,并加以分析研究。 结果 :34例不良反应报告中女性明显多于男性;不良反应以心血管系统损害最多(23例,占6766%),其次为皮肤及附件损害(5例,1470%);不良反应预后较好。 结论 :患者的性别、体质、合并用药等因素能影响不良反应的发生,对于引起心律失常不良反应临床应提高警惕,减少不良反应的发生。Abstract: Objective: To analyze the clinical features、correlation factors of ADRs caused by Terfenadine drugs and provide beneficial references for preventing and curing the ADRs. Methods :To collect and analyze the cases of ADRs caused by Terfenadine from medical journals of 19862008 Results :Women were more than men in 34 ADRs;cardiovascular system lesions accounted for 6766%,skin and its appendix lesions accounted for 1470%;ADRs prognosis well. Conclusion :The occurrence of ADRs caused by Terfenadine due to many factors such as sex、age and combination drug,ect. The ADRs caused by second generation antihistamine drugs must be reconstred.
We searched and retrieved literature on the topic of medical image processing published on SCI journals in the past 10 years. We then imported the retrieved literature into TDA for data cleanup before data analysis and processing by EXCLE and UCINET to generate tables and figures that could indicate disciplinary correlation and research hotspots from the perspective of bibliometrics. The results indicated that people in Europe and USA were leading researchers on medical image processing with close international cooperation. Many disciplines contributed to the fast development of medical image processing with intense interdisciplinary researches. The papers that we found show recent research hotspots of the algorithm, system, model, image and segmentation in the field of medical image processing. Cluster analysis on key words of high frequency demonstrated complicated clustering relationship.
Objective To explore the quality of the reporting of randomized controlled trials (RCTs) published in the Chinese Journal of Integrated Traditional and Western Medicine from 1999 to 2004. Methods A manual search was performed and the 22 checklists of CONSORT statement and other self-established criteria were applied. Results Six volumes and 72 issues were checked. There were 1 874 clinical trials of which 1288 (68.73%) RCTs were identified in 2 765 articles. Randomization methods were described in 630 (48.92%) RCTs which showed there was more significant difference than the RCTs published in 1998 (Plt;0.001).In the 1288 RCTs, placebo control was reported only in 21 trials (1.63%) and endpoint measurements were reported in 114 trials (8.85%). Seven trials (0.55%) mentioned the estimation of sample size. None mentioned randomization concealment. Blinding was reported in 54 trials (4.2%) and P value was reported in 9 trials (0.70%).Flow chart was not mentioned in any trials. Compliance was reported in 2 trials (0.16%), and only one trial (0.08%) reported negative results. Ancillary analysis was used in 33 trials (2.57%). 10 trials are multi-centre RCTs. None of the trials reported the approval of ethics committee. Informed consent was reported in 3 trials (0.24%). Acknowledgements were mentioned in 3 trials (0.24%). Syndrome types defined by traditional Chinese medicine (TCM) were reported in 163 trials (12.66%). The criteria of intervention quality control was mentioned in 2 trials (0.15%). Double dummy was used in 8 trials (0.63%) and outcome measurement of TCM was reported in 258 trials (20.04%). All Items reported in RCTs were of low quality. Conclusions The quality of reporting of RCTs published in the Chinese Journal of Integrated Traditional and Western Medicine from 1999 to 2004 has been improved, but it does not meet the CONSORT statement.